Related Products of 92933-47-6, A common heterocyclic compound, 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, molecular formula is C7H10N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step A Ethyl 3-isopropyl-1H-pyrazole-5-carboxylate (7a)To a solution of 3-isopropyl-1H-pyrazole-5-carboxylic acid (2.5 g, 16.2 mmol) [commercially available from Alfa Aesar, Ward Hill, MA, USA] in MeOH (25 mL) was added cone, sulfuric acid (1 mL) and refluxed for 12h. The reaction mixture was cooled and the solvent was removed under reduced pressure. The crude mass was purified by flash column chromatography using 1:9 MeOH in CHCl3 to yield compound 7a (2.6 g). 1H NMR (400 MHz, CDCl3): delta 6.64 (s, 1H), 4.39 (q, J=8.00 Hz, 2H), 3.06-3.01 (m, 1H), 1.39 (t, J=8.00 Hz, 3H), 1.31 (d, J=8.00 Hz, 6H). Molecular Formula: C9H14N2O2, LCMS purity: 96%; Expected: 182.1 ; Observed: 183 (M+1).
The synthetic route of 92933-47-6 has been constantly updated, and we look forward to future research findings.