These common heterocyclic compound, 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 5-Isopropyl-1H-pyrazole-3-carboxylic acid
Step 4 (R)-3-bromo-l-(1-(3-isopropyl-IH-pyrazole-5-earbonyl)pyrrolidin-3-yl)pyridin-2(lII)-onemixture of (R)-3-bromo-1-(pyrrolidin-3-yl)pyridin-2(1J])-one (3 g, 12.34 mmol), 3-isopropyl- 11-1-pyrazole-5-carboxylic acid (2.1 g, 13.58 mmol), HATU (5.6 g, 14.8 Immol) and DIEA (6.5837.02 mmol) in DMF (30 rnL) was stirred at room temperature for 12 hrs. The mixture wasdiluted with EtOAc (60 mL), washed with brine (60 mL x 2). The organic layer was dried over anhydrous Na2SO4, filtered and concentrated. The crude residue was purified by preparative TLC (DCM: MeOH = 50: 1) to afford the desired product (1.6 g, 34% yield) as a light yellow solid. LCMS M/Z (M+Na) = 402.8.
The synthetic route of 5-Isopropyl-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.