Reference of 51985-95-6,Some common heterocyclic compound, 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, molecular formula is C6H8N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1: To a solution of methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate (2.0 g, 12.8 mmol) inCH3CN (47 mL) was added phosphorus(V)oxybromide (18.3 g, 63.8 mmol) and the mixture was heated to80 C for 18 h. The reaction mixture was chilled in an ice bath and sat. Na2CO3 solution was added. Themixture was extracted with EtOAc, the combined organic layers were dried and the volatiles wereremoved under reduced pressure to yield the desired product.LC-MS (Method 2): mlz [M+H] = 219.0 (MW calc. = 219.04); Rt = 0.45 mm.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, its application will become more common.