Category: 37687-24-4

Adding a certain compound to certain chemical reactions, such as: 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 37687-24-4, Recommanded Product: Diethyl 3,5-pyrazoledicarboxylate

To a solution of diethyl 1H-pyrazole-3,5-dicarboxylate (10.0 g, 47 mmol) and chloroacetone (3.76 mL, 47 mmol) in acetone (200 mL) was added potassium carbonate (7.2 g, 52 mmol). After heating at 30 C. for 6 h, the mixture was concentrated to remove the volatiles. The residue was taken into EtOAc and washed with water. The organics were dried over MgSO4 and concentrated to give diethyl 1-(2-oxopropyl)-1H-pyrazole-3,5-dicarboxylate as a light brown solid, which was used directly in the next step, MS m/z 269.1 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Diethyl 3,5-pyrazoledicarboxylate, other downstream synthetic routes, hurry up and to see.

Reference of 37687-24-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 2-bromo-1-(3,4-dihydro-1H-isochromen-/-yl)ethanone (Intermediate 63A, 2.30 g, 8.1 mmol, 90% purity) in acetone (35 ml) were added diethyl 1H-pyrazole-3,5-dicarboxylate (1.56 g, 7.4 mmol) and potassium carbonate (2.75 g, 19.9 mmol). After stirring overnight at room temperature, the solids were filtered off, and the filtrate was concentrated under reduced pressure. The res-idue was purified by flash-chromatography on silica gel (eluent: petroleum ether/ethyl acetate 4:1)to give 2.40 g (83% of theory) of the title compound. LC/MS [Method 23]: Ri = 0.91 min; MS (ESlpos): m/z = 387 [M+H]?.1H-NMR (400 MHz, DMSO-d): 5 [ppm] = 7.84-7.86 (m, 1H), 7.76 (s, 1H), 7.35-7.38 (m, 2H), 6.20 (s, 2H), 4.77 (s, 2H), 4.31 (gq, 2H), 4.20 (q, 2H), 3.92 (t, 2H), 2.89 (t, 2H), 1.31 (t, 3H), 1.17 (t, 3H).

The chemical industry reduces the impact on the environment during synthesis Diethyl 3,5-pyrazoledicarboxylate. I believe this compound will play a more active role in future production and life.

37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 37687-24-4

A mixture of 2-bromo-1-(4-methyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)ethanone hydrobromide (Intermediate 28A, 1.77 g, 3.2 mmol, 63% purity), diethyl 1H-pyrazole-3,5-dicarboxylate (642 mg, 3.0 mmol) and potassium carbonate (2.09 g, 15.1 mmol) in acetone (40 ml) was stirred overnight at room temperature. The solids were filtered off, and the filtrate was concentrated under re- duced pressure. The residue was purified by flash-chromatography on silica gel (eluent: petrole- um ether/ ethyl acetate 2:1) to give 1.18 g (96% of theory) of the title compound. LC/MS [Method 14]: Rt = 1.21 min; MS (ESIpos): m/z = 402 [M+H]+. 1H-NMR (300 MHz, DMSO-d6): d [ppm] = 7.44 (s, 1H), 7.28-7.33 (m, 2H), 6.83 (d, 1H), 6.06 (s, 2H), 4.36-4.45 (m, 4H), 4.28 (q, 2H), 3.28-3.31 (m, 2H), 2.92 (s, 3H), 1.40 (t, 3H), 1.31 (t, 3H).

The synthetic route of 37687-24-4 has been constantly updated, and we look forward to future research findings.

Application of 37687-24-4, These common heterocyclic compound, 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Crude 2-chloro- 1 -(1 -(4-methoxybenzyl)- 1 H-pyrazol-4-yl)ethanone (7.1 g, 21 mmol) was dissolved in acetonitrile (100 mL). Diethyl 1H-pyrazole-3,5-dicarboxylate (4.6 g, 21 mmol) was added, followed by K2C03 (5.9 g, 43 mmol), and the reaction mixture was stirred at 45 C for 1 hour. The reaction mixture was cooled to ambient temperature, diluted with EtOAc, filtered and concentrated. The residue was purified over silica gel to afford diethyl 1 -(2- (1 -(4-methoxybenzyl)- 1 H-pyrazol-4-yl)-2-oxoethyl)- 1 H-pyrazole-3 ,5-dicarboxylate (8.7 g, 20 mmol, 92 % yield) as a white solid.

The synthetic route of 37687-24-4 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, A new synthetic method of this compound is introduced below., Computed Properties of C9H12N2O4

To a solution of diethyl 1H-pyrazole-3,5-dicarboxylate (0.25 g, 1.18 mmol) in acetone (10 ml) were added 2-bromo-1-(3-fluoro-4-methylphenyl)ethanone (0.33 g, 1.41 mmol) and potassium carbonate (0.41 g, 2.95 mmol). The mixture was stirred at RT over night. After filtering off the sol- ids, the filtrate was concentrated and the residue dried in vacuo to give 0.48 g (99% of theory, 87% purity) of the title compound. This compound was used without further purification. LC/MS [Method 3]: Rt = 2.07 min; MS (ESIpos): m/z = 363 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, A new synthetic method of this compound is introduced below., HPLC of Formula: C9H12N2O4

2-fluorobenzyl bromide (2.0 ml, 16.58 mmol) was added to a mixture of diethyl 3,5-pyrazoledicarboxylate (3.01 g, 14.18 mmol), Cs2CO3 (5.57 g, 17.1 mmol), and acetonitrile (140 ml) under N2. Heated to 60 C. for two hours and then cooled to room temperature. Filtered and concentrated the reaction solution. Added water (~200 mL) to the resulting residue and extracted with EtOAc. Washed organics with water and brine. Dried organics over sodium sulfate and filtered and concentrated. Obtained diethyl 1-(2-fluorobenzyl)-1H-pyrazole-3,5-dicarboxylate (light-yellow oil) in quantitative yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 37687-24-4, SDS of cas: 37687-24-4

A solution of aminoacetaldehyde dimethyl acetal (0.23 mL, 2.12 mmol). in THF (dry) was cooled at 0C and a solution of trimethylaluminium (1.06 mL, 2.12 mmol) was added drop wise to the cold reaction mixture under nitrogen. The reaction mixture was allowed to warm to room temperature over 15 minutes. The reaction mixture was cooled again to 0C and treated with a solution of diethyl pyrazole-3,5-dicarboxylate 2a (300 mg, 1.41 mmol) in THF (dry) under nitrogen over a period of 15-20 minutes. The resulting reaction mixture was warmed to room temperature and stirred for 2 h. The excess trimethylaluminium was quenched by addition of methanol carefully; when the effervescence was ceased, it was filtered and washed with excess of 10% MeOH in DCM (25 mL). The filtrate was collected and evaporated under reduced pressure to dryness. The resulting crude material was purified by column chromatography (Silica gel 100-200 mesh size, 4% MeOH in DCM) to give compound 10 (285 mg, 50%). MS (ES+) m/z: 272. 1H NMR (DMSO-d6): delta 14.15-14.56 (s, 1H), 8.14-8.87 (m, 1H), 7.10-7.51 (m, 1H), 4.50 (t, J=5.40 Hz, 1H), 4.30 (q, J=7.03 Hz, 2H), 3.34-3.37 (m, 2H), 3.28 (s, 6H), 1.31 (t, J=7.03 Hz, 3H).

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Electric Literature of 37687-24-4, A common heterocyclic compound, 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, molecular formula is C9H12N2O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 41; (5R, 6E&Z)-7-oxo-6- (4H, 10H-pyrazolo [5, 1-c] [1, 4] benzoxazepin-2-ylmethylene)-4- thia-1-azabicyclo [3. 2. 0] hept-2-ene-2-carboxylic acid, sodium salt Step 1: Preparation of 1-(2-fluorobenzyl)-1H-pyrazole-3,5-dicarboxylate 2-fluorobenzyl bromide (2.0 ml, 16.58 mmol) was added to a mixture of diethyl 3,5- pyrazoledicarboxylate (3.01 g, 14.18 mmol), Cs2CO3 (5.57 g, 17.1 mmol), and acetonitrile (140 ml) under N2. Heated to 60C for two hours and then cooled to room temperature. Filtered and concentrated the reaction solution. Added water (-200mL) to the resulting residue and extracted with EtOAc. Washed organics with water and brine. Dried organics over sodium sulfate and filtered and concentrated. Obtained diethyl 1- (2- fluorobenzyl)-1 H-pyrazole-3, 5-dicarboxylate (light-yellow oil) in quantitative yield.

The synthetic route of 37687-24-4 has been constantly updated, and we look forward to future research findings.

Electric Literature of 37687-24-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

N-iodosuccinimide (0.6 g, 2.59 mmol) was added to a solution of diethyl 3,5- pyrazoledicarboxylate (0.5 g, 2.35 mmol) in CHCI3 (10 mL) and the mixture was stirred at 80 C for 24 hours. Then more of N-iodosuccinimide (0.6 g, 2.59 mmol) was added and the mixture was stirred at 100 C for 48 hours more. Then the mixture was stirred at room temperature for 5 days. Then the mixture was treated with a saturated solution of Na2S203 and extracted with DCM. The organic layer was separated, dried (MgS04), filtered and the solvents evaporated in vacuo. The crude product was purified by flash columnchromatography (silica; MeOH in DCM 0/100 to 10/90). The desired fractions were collected and the solvents evaporated in vacuo to yield 4-iodo-lH-pyrazole-3,5-dicarboxylic acid diethyl ester (0.83 g, 90% yield).

The synthetic route of Diethyl 3,5-pyrazoledicarboxylate has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of Diethyl 3,5-pyrazoledicarboxylate

General procedure: n-Butyltriphenylphosphonium peroxodisulfate (0.5 mmol) was added in small portions to a solution of pyrazole (1 mmol) and iodine (0.6 mmol) in CH3CN/H2O (10 : 2 mL) in a 50 mL round-bottome flask equipped with a magnetic stirrer. The reaction mixture was stirred at ambient temperature for the appropriate time (see table). Upon completion of the reaction, as indicated by TLC, the reaction mixture was poured into an aqueous sodium thiosulfate solution (1 M) and extracted with diethyl ether (3 ¡Á 15 mL). The combined organic layers were dried over MgSO4. The solvent was concentrated in vacuo, the resulting product was purified on silica gel using column chromategraphy (diethyl ether : n-hexane = 1 : 4) to afford the pure compound.

According to the analysis of related databases, 37687-24-4, the application of this compound in the production field has become more and more popular.