Application of 37687-24-4, These common heterocyclic compound, 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Crude 2-chloro- 1 -(1 -(4-methoxybenzyl)- 1 H-pyrazol-4-yl)ethanone (7.1 g, 21 mmol) was dissolved in acetonitrile (100 mL). Diethyl 1H-pyrazole-3,5-dicarboxylate (4.6 g, 21 mmol) was added, followed by K2C03 (5.9 g, 43 mmol), and the reaction mixture was stirred at 45 C for 1 hour. The reaction mixture was cooled to ambient temperature, diluted with EtOAc, filtered and concentrated. The residue was purified over silica gel to afford diethyl 1 -(2- (1 -(4-methoxybenzyl)- 1 H-pyrazol-4-yl)-2-oxoethyl)- 1 H-pyrazole-3 ,5-dicarboxylate (8.7 g, 20 mmol, 92 % yield) as a white solid.
The synthetic route of 37687-24-4 has been constantly updated, and we look forward to future research findings.