Category: 288148-34-5

Reference of 288148-34-5,Some common heterocyclic compound, 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, molecular formula is C4H5ClN2O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of the appropriate (aryloxy)ethyl piperidine(0.38 mmol) in CH2Cl2 (3 mL), and TEA (1.14 mmol) was cooled down (ice bath), and arylsulfonyl chloride (0.46 mmol) was added at 0 C in one portion. The reaction mixture was stirred for 2-6 h under cooling. Then, the solvent was evaporated and the sulfonamides were purified using silica gel column with CH2Cl2/MeOH as an eluting system. Free bases were then converted into the hydrochloride salts by treatment of their solution in anhydrous ethanol with 1.25 M HCl in MeOH.; 9.2.6.4 1-Methyl-N-(1-{2-[(propan-2-yl)phenoxy]ethyl}piperidin-4-yl}-N-methyl-1H-pyrazole-4-sulfonamide (13) Yellow oil, 90 mg following chromatographic purification over silica gel with CH2Cl2/MeOH (9:0.7); LC/MS purity 96%, tR = 4.47, C21H32N4O3S, MW 420.57, Monoisotopic Mass 420.22, [M+H]+ 421.3 1H NMR (300 MHz, CDCl3) delta 1.19 (d, J = 6.92 Hz, 6H), 1.49-1.58 (m, 2H), 1.71 (qd, J = 12.21, 3.88 Hz, 2H), 2.22 (td, J = 11.89, 2.24 Hz, 2H), 2.73 (s, 3H), 2.81 (t, J = 5.72 Hz, 2H), 2.99-3.07 (m, 2H), 3.29 (quin, J = 6.92 Hz, 1H), 3.81 (tt, J = 11.97, 4.22 Hz, 1H), 3.92 (s, 3H), 4.06 (t, J = 5.72 Hz, 2H), 6.80 (dd, J = 8.14, 0.99 Hz, 1H), 6.88-6.94 (m, 1H), 7.12 (td, J = 7.76, 1.73 Hz, 1H), 7.20 (dd, J = 7.53, 1.67 Hz, 1H), 7.70 (d, J = 0.61 Hz, 1H), 7.74 (s, 1H). 13C NMR (75 MHz, CDCl3) delta 22.70, 26.73, 28.60, 29.27, 39.55, 53.47, 55.03, 57.13, 66.40, 111.26, 120.78, 122.21, 126.06, 126.53, 131.37, 137.03, 138.15, 155.79.

The synthetic route of 288148-34-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Canale, Vittorio; Kurczab, Rafa?; Partyka, Anna; Sata?a, Grzegorz; S?oczy?ska, Karolina; Kos, Tomasz; Jastrz?bska-Wi?sek, Magdalena; Siwek, Agata; P?kala, Elzbieta; Bojarski, Andrzej J.; Weso?owska, Anna; Popik, Piotr; Zajdel, Pawe?; Bioorganic and Medicinal Chemistry; vol. 24; 2; (2016); p. 130 – 139;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, A new synthetic method of this compound is introduced below., Quality Control of 1-Methyl-1H-pyrazole-4-sulfonyl chloride

General procedure: A mixture of the appropriate (aryloxy)ethyl piperidine(0.38 mmol) in CH2Cl2 (3 mL), and TEA (1.14 mmol) was cooled down (ice bath), and arylsulfonyl chloride (0.46 mmol) was added at 0 C in one portion. The reaction mixture was stirred for 2-6 h under cooling. Then, the solvent was evaporated and the sulfonamides were purified using silica gel column with CH2Cl2/MeOH as an eluting system. Free bases were then converted into the hydrochloride salts by treatment of their solution in anhydrous ethanol with 1.25 M HCl in MeOH.; 9.2.6.8 1-Methyl-N-(1-{[2-(t-butyl-2-yl)phenoxy]ethyl}piperidin-4-yl)-N-methyl-1H-pyrazole-sulfonamide (17) Yellow oil, 80 mg following chromatographic purification over silica gel with CH2Cl2/MeOH (9:0.7); LC/MS purity 100%, tR = 4.81, C22H34N4O3S, MW 434.60, Monoisotopic Mass 434.24, [M+H]+ 435.5. 1H NMR (300 MHz, CDCl3) delta 1.37 (s, 9H), 1.50-1.58 (m, 2H), 1.70 (qd, J = 12.17, 3.89 Hz, 2H) 2.19 (td, J = 11.80, 2.23 Hz, 2H), 2.73 (s, 3H), 2.82 (t, J = 6.07 Hz, 2H), 2.97-3.04 (m, 2H), 3.76-3.88 (m, 1H), 3.93 (s, 3H), 4.06 (t, J = 6.06 Hz, 1H), 6.83 (dd, J = 8.21, 1.03 Hz, 1H), 6.87-6.91 (m, 1H), 7.15 (td, J = 7.71, 1.70 Hz, 1H), 7.27 (dd, J = 7.92, 1.44 Hz, 1H), 7.70 (s, 1H), 7.74 (s, 1H). 13C NMR (75 MHz, CDCl3) delta 28.58, 29.28, 29.68, 29.81, 34.81, 39.55, 53.48, 55.09, 57.13, 65.94, 112.03, 120.39, 122.24, 126.64, 126.97, 131.35, 138.10, 138.15, 157.49. Anal. calcd for C22H34N4O3S·2HCl: C: 52.06, H: 7.15, N: 11.04, S: 6.32; Found C: 51.95, H: 6.95, N: 10.82, S: 6.11. Mp for C22H34N4O3S·2HCl: 181.7-182.3 C.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Canale, Vittorio; Kurczab, Rafa?; Partyka, Anna; Sata?a, Grzegorz; S?oczy?ska, Karolina; Kos, Tomasz; Jastrz?bska-Wi?sek, Magdalena; Siwek, Agata; P?kala, Elzbieta; Bojarski, Andrzej J.; Weso?owska, Anna; Popik, Piotr; Zajdel, Pawe?; Bioorganic and Medicinal Chemistry; vol. 24; 2; (2016); p. 130 – 139;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 288148-34-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 288148-34-5 name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Reference Example 106; tert-butyl ( {4-fluoro-5- (2-fluoropyridin-3-yl) -1- [ (1-methyl- lH-pyrazol-4-yl) sulfonyl] -lH-pyrrol-3- yl }methyl) methylcarbamate; To a solution of tert-butyl { [4-fluoro-5- (2- fluoropyridin-3-yl) -lH-pyrrol-3-yl]methyl }methylcarbamate (324 mg) in tetrahydrofuran (20 itiL) was added sodium hydride (60% in oil, 121 mg) at room temperature and the mixture was stirred for 15 min. 15-Crown-5 (664 mg) was added dropwise and the mixture was stirred for 5 min. l-Methyl-lH-pyrazole-4- sulfonyl chloride (362 mg) was added, and the mixture was further stirred for 30 min. The reaction mixture was diluted with saturated aqueous sodium hydrogen carbonate, and extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate=l:l) to give the title compound as a colorless oil (yield 460 mg, 98%) .1H-NMR (CDCl3) delta: 1.48(9H,s), 2.88(3H,s), 3.87(3H,s),4.27(2H,brs) , 7.21 (IH, d, J=4.9Hz) , 7.30 (IH, t, J=6.1) , 7.41(lH,br), 7.42(lH,s), 7.86 (IH, t, J=8. IHz) ,8.29 (lH,d, J=4.9Hz) .

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-pyrazole-4-sulfonyl chloride, and friends who are interested can also refer to it.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2008/108380; (2008); A2;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, A new synthetic method of this compound is introduced below., category: pyrazoles-derivatives

General procedure: A mixture of the appropriate (aryloxy)ethyl piperidine(0.38 mmol) in CH2Cl2 (3 mL), and TEA (1.14 mmol) was cooled down (ice bath), and arylsulfonyl chloride (0.46 mmol) was added at 0 C in one portion. The reaction mixture was stirred for 2-6 h under cooling. Then, the solvent was evaporated and the sulfonamides were purified using silica gel column with CH2Cl2/MeOH as an eluting system. Free bases were then converted into the hydrochloride salts by treatment of their solution in anhydrous ethanol with 1.25 M HCl in MeOH.; 9.2.6.16 1-Methyl-N-{1-[2-(2-(t-butyl)phenoxy)ethyl]piperidin-4-yl}-N-cyclopropylmethyl-1H-pyrazole-4-sulfonamide (31) Yellow oil, 110 mg following chromatographic purification over silica gel with CH2Cl2/MeOH (9:0.5); LC/MS purity 100%, tR = 6.24, C25H38N4O3S, MW 474.66, Monoisotopic Mass 474.27, [M+H]+ 475.2 1H NMR (300 MHz, CDCl3) delta 0.25-0.31 (m, 2H), 0.51-0.57 (m, 2H), 1.38 (s, 9H), 1.56-1.63 (m, 2H), 1.74-1.89 (m, 2H), 2.18-2.21 (m, 3H), 2.84 (t, J = 5.92 Hz, 2H), 3.03 (d, J = 11.55 Hz, 2H), 3.10 (d, J = 6.76 Hz, 2H), 3.61-3.64 (m, 1H), 3.91 (s, 3H), 4.12 (t, J = 5.95 Hz, 2H), 6.88 (qd, J = 7.73, 0.98 Hz, 2H), 7.14 (td, J = 7.72, 1.68 Hz, 1H), 7.24-7.29 (m, 1H), 7.66-7.70 (m, 1H), 7.78 (s, 1H). 13C NMR (75 MHz, CDCl3) delta 5.12, 12.47, 29.69, 29.80, 30.01, 30.77, 34.81, 48.31, 53.79, 55.84, 57.08, 65.81, 112.03, 115.99, 116.28, 120.44, 126.66, 126.99, 129.42, 129.54, 138.09, 157.46, 163.05, 166.41. Anal. calcd for C25H38N4O3S·HCl: C, 58.75; H, 7.69; N, 10.96; S, 6.27; Found: C, 58.94; H, 7.79; N, 10.72; S, 6.16. Mp for C25H38N4O3S·HCl: 193.7-194.5 C.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Canale, Vittorio; Kurczab, Rafa?; Partyka, Anna; Sata?a, Grzegorz; S?oczy?ska, Karolina; Kos, Tomasz; Jastrz?bska-Wi?sek, Magdalena; Siwek, Agata; P?kala, Elzbieta; Bojarski, Andrzej J.; Weso?owska, Anna; Popik, Piotr; Zajdel, Pawe?; Bioorganic and Medicinal Chemistry; vol. 24; 2; (2016); p. 130 – 139;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 288148-34-5, These common heterocyclic compound, 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 4-(5-fluoro-lH-indol-3-yl)-iV’-(4-piperazin-l-ylphenyl)pyrimidin-2-amine (20 mg, 0.051 mmol) in dimethylforamide (1 mL), were added l-methyl-lH-pyrazole-4-sulfonyl chloride (9.3 mg, 0.051 mmol), triethylamine (31.3 mg, 0.309 mmol), and 4-dimethylamino pyridine (cat.). The solution was allowed to stir for 12 hr. After completion of the reaction, the reaction mixture was concentrated and purified by reverse phase chromatography (100% H2O to 100% MeCN) to afford ^(S-fluoro-lH-indol-S-y^-N^-f^tCl-methyl-lH-pyrazoM- yl)sulfonyl]piperazin-l-yl}phenyl)pyrimidin-2-amine as a mono trifluoroacetic acid salt. LRMS m/z (M+H) Calcd: 533.2, found: 533.1.

The synthetic route of 288148-34-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK & CO., INC.; WO2007/149427; (2007); A2;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Some common heterocyclic compound, 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, molecular formula is C4H5ClN2O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-Methyl-1H-pyrazole-4-sulfonyl chloride

General procedure: A mixture of the appropriate (aryloxy)ethyl piperidine(0.38 mmol) in CH2Cl2 (3 mL), and TEA (1.14 mmol) was cooled down (ice bath), and arylsulfonyl chloride (0.46 mmol) was added at 0 C in one portion. The reaction mixture was stirred for 2-6 h under cooling. Then, the solvent was evaporated and the sulfonamides were purified using silica gel column with CH2Cl2/MeOH as an eluting system. Free bases were then converted into the hydrochloride salts by treatment of their solution in anhydrous ethanol with 1.25 M HCl in MeOH.; 9.2.6.11 1-Methyl-N-{1-[2-(biphenyl-2-yloxy)ethyl]piperidin-4-yl}-N-methyl-1H-pyrazole-4-sulfonamide (20) Yellow oil, 100 mg following chromatographic purification over silica gel with CH2Cl2/MeOH (9:0.7); LC/MS purity 100%, tR = 4.65, C24H30N4O3S, MW 454.58, Monoisotopic Mass 454.20, [M+H]+ 455.5. 1H NMR (300 MHz, CDCl3) delta 1.40-1.48 (m, 2H), 1.62-1.65 (m, 2H), 2.05 (td, J = 11.90, 2.20 Hz, 2H), 2.66-2.70 (m, 2H), 2.71 (s, 3H), 2.83-2.90 (m, 2H), 3.68-3.80 (m, 1H), 3.94 (s, 3H), 4.04 (t, J = 5.63 Hz, 2H), 6.93-6.97 (m, 1H), 7.03 (td, J = 7.45, 1.06 Hz, 1H), 7.28-7.33 (m, 3H), 7.34-7.40 (m, 2H), 7.49-7.51 (m, 1H), 7.51-7.53 (m, 1H), 7.69 (d, J = 0.54 Hz, 1H), 7.73 (s, 1H). 13C NMR (75 MHz, CDCl3) delta 28.59, 29.19, 39.57, 53.35, 55.00, 56.78, 66.94, 112.70, 121.18, 122.22, 126.83, 127.79, 128.58, 129.61, 130.86, 131.13, 131.35, 138.17, 138.48, 155.63. Anal. calcd for C24H30N4O3S·HCl: C: 58.70, H: 6.36, N: 11.41, S: 6.53; Found C: 58.96, H: 6.49, N: 11.42, S: 6.88. Mp for C24H30N4O3S·HCl: 189.5-189.9 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 288148-34-5, its application will become more common.

Reference:
Article; Canale, Vittorio; Kurczab, Rafa?; Partyka, Anna; Sata?a, Grzegorz; S?oczy?ska, Karolina; Kos, Tomasz; Jastrz?bska-Wi?sek, Magdalena; Siwek, Agata; P?kala, Elzbieta; Bojarski, Andrzej J.; Weso?owska, Anna; Popik, Piotr; Zajdel, Pawe?; Bioorganic and Medicinal Chemistry; vol. 24; 2; (2016); p. 130 – 139;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 288148-34-5, Recommanded Product: 1-Methyl-1H-pyrazole-4-sulfonyl chloride

The previous product (200 mg, 0.59 mmol) was dissolved in dichloromethane (5 mL). N1N- Diisopropylethylamine (0.15 mL, 0.88 mmol) was added followed by 1 -methyl- lH-pyrazole-4-sulfonyl chloride (116 mg, 0.64 mmol). The mixture was stirred for 2 hours at room temperature then purified directly by flash column chromatography on silica gel using a 20 % ethyl acetate : 80 % dichloromethane mixture as eluent to afford the title compound(160 mg).1H NMR delta (ppm)(CDCl3): 7.75 (1 H, s), 7.73 (IH, s), 7.61 (1 H, d, J = 8.3 Hz), 7.43 (1 H, d, J = 1.8 Hz), 7.33 (1 H, dd, J = 1.9, 8.3 Hz), 6.26 (1 H, m), 3.98 (3 H, s), 3.48 (2 H, d, J = 6.4 Hz), 3.22-3.18 (2 H, m), 3.02-2.96 (2 H, m), 1.74-1.67 (4 H, m), 1.27-1.25 (2 H, m), 0.67-0.61 (1 H, m), 0.52 (2 H, m), 0.05 (2 H, m). m/z (ES+) 485 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-pyrazole-4-sulfonyl chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2006/67529; (2006); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 288148-34-5, A common heterocyclic compound, 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, molecular formula is C4H5ClN2O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In the 0 C, the 6-amino-2-(difluoromethyl)-7-methylquinolin-4-yl acetate (0.21 g, 0.8 mmol) and pyridine (10 ml) are added to the 50 ml single-port in the bottle, and then the 1-methylpyrazole-4-sulfonyl chloride (0.22 g, 1.2 mmol) is slowly added to the reaction system, after adding to rise to room temperature to continue the reaction 12 hours. After the reaction by adding ethyl acetate (30 ml), washed with water (20 ml x3), the organic phase is dried with anhydrous sodium sulfate, filtered, concentrated under reduced pressure of the filtrate, the residue by silica gel column chromatography separation [petroleum ether/ethyl acetate (v/v)=3/1], to obtain 162 mg yellow solid, yield: 49.4%.

The synthetic route of 288148-34-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dongguan Dongyang Guang Ke Research And Development Co., Ltd.; Li Yitao; Li Falin; Chen Tao; Xu Junxing; Yao Wenqiang; Lin Jian; Liu Xinshuo; (56 pag.)CN109320452; (2019); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 288148-34-5,Some common heterocyclic compound, 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, molecular formula is C4H5ClN2O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of the appropriate (aryloxy)ethyl piperidine(0.38 mmol) in CH2Cl2 (3 mL), and TEA (1.14 mmol) was cooled down (ice bath), and arylsulfonyl chloride (0.46 mmol) was added at 0 C in one portion. The reaction mixture was stirred for 2-6 h under cooling. Then, the solvent was evaporated and the sulfonamides were purified using silica gel column with CH2Cl2/MeOH as an eluting system. Free bases were then converted into the hydrochloride salts by treatment of their solution in anhydrous ethanol with 1.25 M HCl in MeOH.; 9.2.6.4 1-Methyl-N-(1-{2-[(propan-2-yl)phenoxy]ethyl}piperidin-4-yl}-N-methyl-1H-pyrazole-4-sulfonamide (13) Yellow oil, 90 mg following chromatographic purification over silica gel with CH2Cl2/MeOH (9:0.7); LC/MS purity 96%, tR = 4.47, C21H32N4O3S, MW 420.57, Monoisotopic Mass 420.22, [M+H]+ 421.3 1H NMR (300 MHz, CDCl3) delta 1.19 (d, J = 6.92 Hz, 6H), 1.49-1.58 (m, 2H), 1.71 (qd, J = 12.21, 3.88 Hz, 2H), 2.22 (td, J = 11.89, 2.24 Hz, 2H), 2.73 (s, 3H), 2.81 (t, J = 5.72 Hz, 2H), 2.99-3.07 (m, 2H), 3.29 (quin, J = 6.92 Hz, 1H), 3.81 (tt, J = 11.97, 4.22 Hz, 1H), 3.92 (s, 3H), 4.06 (t, J = 5.72 Hz, 2H), 6.80 (dd, J = 8.14, 0.99 Hz, 1H), 6.88-6.94 (m, 1H), 7.12 (td, J = 7.76, 1.73 Hz, 1H), 7.20 (dd, J = 7.53, 1.67 Hz, 1H), 7.70 (d, J = 0.61 Hz, 1H), 7.74 (s, 1H). 13C NMR (75 MHz, CDCl3) delta 22.70, 26.73, 28.60, 29.27, 39.55, 53.47, 55.03, 57.13, 66.40, 111.26, 120.78, 122.21, 126.06, 126.53, 131.37, 137.03, 138.15, 155.79.

The synthetic route of 288148-34-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Canale, Vittorio; Kurczab, Rafa?; Partyka, Anna; Sata?a, Grzegorz; S?oczy?ska, Karolina; Kos, Tomasz; Jastrz?bska-Wi?sek, Magdalena; Siwek, Agata; P?kala, Elzbieta; Bojarski, Andrzej J.; Weso?owska, Anna; Popik, Piotr; Zajdel, Pawe?; Bioorganic and Medicinal Chemistry; vol. 24; 2; (2016); p. 130 – 139;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Methyl-1H-pyrazole-4-sulfonyl chloride

General procedure: A mixture of the appropriate (aryloxy)ethyl piperidine(0.38 mmol) in CH2Cl2 (3 mL), and TEA (1.14 mmol) was cooled down (ice bath), and arylsulfonyl chloride (0.46 mmol) was added at 0 C in one portion. The reaction mixture was stirred for 2-6 h under cooling. Then, the solvent was evaporated and the sulfonamides were purified using silica gel column with CH2Cl2/MeOH as an eluting system. Free bases were then converted into the hydrochloride salts by treatment of their solution in anhydrous ethanol with 1.25 M HCl in MeOH.; 9.2.6.8 1-Methyl-N-(1-{[2-(t-butyl-2-yl)phenoxy]ethyl}piperidin-4-yl)-N-methyl-1H-pyrazole-sulfonamide (17) Yellow oil, 80 mg following chromatographic purification over silica gel with CH2Cl2/MeOH (9:0.7); LC/MS purity 100%, tR = 4.81, C22H34N4O3S, MW 434.60, Monoisotopic Mass 434.24, [M+H]+ 435.5. 1H NMR (300 MHz, CDCl3) delta 1.37 (s, 9H), 1.50-1.58 (m, 2H), 1.70 (qd, J = 12.17, 3.89 Hz, 2H) 2.19 (td, J = 11.80, 2.23 Hz, 2H), 2.73 (s, 3H), 2.82 (t, J = 6.07 Hz, 2H), 2.97-3.04 (m, 2H), 3.76-3.88 (m, 1H), 3.93 (s, 3H), 4.06 (t, J = 6.06 Hz, 1H), 6.83 (dd, J = 8.21, 1.03 Hz, 1H), 6.87-6.91 (m, 1H), 7.15 (td, J = 7.71, 1.70 Hz, 1H), 7.27 (dd, J = 7.92, 1.44 Hz, 1H), 7.70 (s, 1H), 7.74 (s, 1H). 13C NMR (75 MHz, CDCl3) delta 28.58, 29.28, 29.68, 29.81, 34.81, 39.55, 53.48, 55.09, 57.13, 65.94, 112.03, 120.39, 122.24, 126.64, 126.97, 131.35, 138.10, 138.15, 157.49. Anal. calcd for C22H34N4O3S·2HCl: C: 52.06, H: 7.15, N: 11.04, S: 6.32; Found C: 51.95, H: 6.95, N: 10.82, S: 6.11. Mp for C22H34N4O3S·2HCl: 181.7-182.3 C.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Canale, Vittorio; Kurczab, Rafa?; Partyka, Anna; Sata?a, Grzegorz; S?oczy?ska, Karolina; Kos, Tomasz; Jastrz?bska-Wi?sek, Magdalena; Siwek, Agata; P?kala, Elzbieta; Bojarski, Andrzej J.; Weso?owska, Anna; Popik, Piotr; Zajdel, Pawe?; Bioorganic and Medicinal Chemistry; vol. 24; 2; (2016); p. 130 – 139;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics