Adding a certain compound to certain chemical reactions, such as: 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 288148-34-5, Recommanded Product: 1-Methyl-1H-pyrazole-4-sulfonyl chloride
The previous product (200 mg, 0.59 mmol) was dissolved in dichloromethane (5 mL). N1N- Diisopropylethylamine (0.15 mL, 0.88 mmol) was added followed by 1 -methyl- lH-pyrazole-4-sulfonyl chloride (116 mg, 0.64 mmol). The mixture was stirred for 2 hours at room temperature then purified directly by flash column chromatography on silica gel using a 20 % ethyl acetate : 80 % dichloromethane mixture as eluent to afford the title compound(160 mg).1H NMR delta (ppm)(CDCl3): 7.75 (1 H, s), 7.73 (IH, s), 7.61 (1 H, d, J = 8.3 Hz), 7.43 (1 H, d, J = 1.8 Hz), 7.33 (1 H, dd, J = 1.9, 8.3 Hz), 6.26 (1 H, m), 3.98 (3 H, s), 3.48 (2 H, d, J = 6.4 Hz), 3.22-3.18 (2 H, m), 3.02-2.96 (2 H, m), 1.74-1.67 (4 H, m), 1.27-1.25 (2 H, m), 0.67-0.61 (1 H, m), 0.52 (2 H, m), 0.05 (2 H, m). m/z (ES+) 485 (M+H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-pyrazole-4-sulfonyl chloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2006/67529; (2006); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics