Electric Literature of 288148-34-5, A common heterocyclic compound, 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, molecular formula is C4H5ClN2O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In the 0 C, the 6-amino-2-(difluoromethyl)-7-methylquinolin-4-yl acetate (0.21 g, 0.8 mmol) and pyridine (10 ml) are added to the 50 ml single-port in the bottle, and then the 1-methylpyrazole-4-sulfonyl chloride (0.22 g, 1.2 mmol) is slowly added to the reaction system, after adding to rise to room temperature to continue the reaction 12 hours. After the reaction by adding ethyl acetate (30 ml), washed with water (20 ml x3), the organic phase is dried with anhydrous sodium sulfate, filtered, concentrated under reduced pressure of the filtrate, the residue by silica gel column chromatography separation [petroleum ether/ethyl acetate (v/v)=3/1], to obtain 162 mg yellow solid, yield: 49.4%.
The synthetic route of 288148-34-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Dongguan Dongyang Guang Ke Research And Development Co., Ltd.; Li Yitao; Li Falin; Chen Tao; Xu Junxing; Yao Wenqiang; Lin Jian; Liu Xinshuo; (56 pag.)CN109320452; (2019); A;,
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