Synthetic Route of 1145-01-3,Some common heterocyclic compound, 1145-01-3, name is 3,5-Diphenyl-1H-pyrazole, molecular formula is C15H12N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2d. Under argon atmosphere, CuI (0.38 g, 2 mmol), proline(0.46 g, 4 mmol) and K2CO3(2.76 g, 20 mmol) were added toa dimethyl sulfoxide (15 mL) solution of 6-bromopyridine-2-carboxylate (4.60 g, 20 mmol) and 3,5-diphenylprazole (4.44 g,20 mmol). The formed mixture was stirred at 80C overnight.Water was added after cooling down to room temperature, and theresulting mixture was extracted with ethyl acetate (3¡Á 20 mL). Theorganic layers were combined and the solvent was removed to givethe crude product, which was purified by column chromatography(3.76 g, 83% yield).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Diphenyl-1H-pyrazole, its application will become more common.