Category: 35277-02-2

Related Products of 35277-02-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35277-02-2, name is 4-Fluoro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 4-Chloro-2-methyl-quinolin-8-ol (30 mg, 0.15 mmol) and 4-Fluoro-lH- pyrazole (Shi, Xifeng; Ishihara, Takashi; Yamanaka, Etairoki; Gupton, John T. Tetrahedron Letters 1995, 36, 1527-1530) (33 mg, 0.39 mmol) in NMP (25 muL) was stirred at 150 C for 90 min. The crude product was purified by reversed phase EtaPLC using a gradient of acetonitrile in water with 0.1 % TFA to give the title compound as the TFA salt. MS (m/z): 244.0 [M+H+]

The chemical industry reduces the impact on the environment during synthesis 4-Fluoro-1H-pyrazole. I believe this compound will play a more active role in future production and life.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35277-02-2 as follows. Safety of 4-Fluoro-1H-pyrazole

Add in 100mL round bottom flask1-bromo-N- (6-cyano-5-trifluoromethyl-pyridin-3-yl) -cyclobutanecarboxamide (0.30 g, 0.8618 mmol),4-fluoro-1H-pyrazole (0.148 g, 1.7236 mmol),Cuprous bromide dimethyl sulfide (17.7 mg, 0.08618 mmol),Triphenylphosphine (22.6 mg, 0.08618 mmol),Tripotassium phosphate (0.22 g, 1.0341 mmol),Sodium hydroxide (38 mg, 0.9480 mmol),10mL of anhydrous toluene was used as the solvent.The resulting mixture was heated to 50 C,Stir for 15 hours under argon protection.After confirming the completion of the reaction by thin layer chromatography,The reaction solution is cooled to 20 ¡À 5 ,Then add water (30 ml) and ethyl acetate (35 ml),After brief stirring, the liquid is separated,The organic phase was washed with brine (25 ml),Magnesium sulfate drying,filter,Drain the organic phase,An oily substance is obtained.Silica gel column chromatography separation (mobile phase is dichloromethane: ethyl acetate = 9: 1), purification,82 mg of yellow powder was obtained,Identified asN- (4-cyano-3-trifluoromethyl) phenyl-1- (4-fluoro-1H-pyrazol-1-yl) -cyclobutanecarboxamide.The yield is 27%.

According to the analysis of related databases, 35277-02-2, the application of this compound in the production field has become more and more popular.

Synthetic Route of 35277-02-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 35277-02-2, name is 4-Fluoro-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step D: 4-fluoro-lH-pyrazole-l-carboxamidine hydrochloride (28-e) To 4-fluoro-lH-pyrazole, 28-d, (2g, 23mmol) and cyanamide (0.97g, 23mmol) in dioxane (5mL) was added 4N HC1 in dioxane (15mL). The mixture was gently refluxed with stirring for 2h under nitrogen. During the course of the reaction the product crystallizes. After cooling to room temperature, 10 mL of anhydrous ether was added and the mixture was allowed to stand for 30min. The white solid was collected by filtration, washed with anhydrous ether and dried to constant weight in vacuuo providing the product, 28-e, (3g, 80%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Fluoro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Reference of 35277-02-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 35277-02-2, name is 4-Fluoro-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To 4-fluoro-lH-pyrazole, 28-d, (2g, 23mmol) and cyanamide (0.97g, 23mmol) in dioxane (5mL) was added 4N HC1 in dioxane (15mL). The mixture was gently refluxed with stirring for 2h under nitrogen. During the course of the reaction the product crystallizes. After cooling to room temperature, 10 mL of anhydrous ether was added and the mixture was allowed to stand for 30min. The white solid was collected by filtration, washed with anhydrous ether and dried to constant weight in vacuuo providing the product, 28-e, (3g, 80%)

The synthetic route of 4-Fluoro-1H-pyrazole has been constantly updated, and we look forward to future research findings.

Electric Literature of 35277-02-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35277-02-2, name is 4-Fluoro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 2-ch loro-N-(2 ,4-d imethoxybenzyl )-5-nitrobenzenesulfonam ide (5.00 g, 11.6 mmol) in acetonitrile (135 mL) were added 4-fluoro-1H-pyrazole (1.50 g, 17.4 mmol) and powdered potassium carbonate (4.82 g, 34.9 mmol) and it was stirred overnight at10000. The reaction mixture was concentrated in vacuo and the residue was extracted with dichioromethane and water. The organic phase was washed with brine and dried over sodium sulfate. Concentration in vacuo led to the crude title compound (5.54 g, quant., app. 85 % purity) that was used without further purification in the next step.LC-MS (Method A): Rt = 1.23 mm; MS (ESIpos): mlz = 437 [M+H]1HNMR (400MHz, DMSO-d6) oe [ppm]: 3.48 (s, 3H), 3.62 (s, 3H), 4.13 (s, 2H), 6.15 (d,1H), 6.28 (dd, 1H), 7.09 (d, 1H), 7.81 (d, 1H), 8.00-8.10 (m, 2H), 8.23 (d, 1H), 8.43 (dd,H), 8.59 (s, 1 H).

The chemical industry reduces the impact on the environment during synthesis 4-Fluoro-1H-pyrazole. I believe this compound will play a more active role in future production and life.

Reference of 35277-02-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35277-02-2, name is 4-Fluoro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

Sodium hydride (13.8 g, 0.35 mol, 60% dispersion in mineral oil) was added to a solution of fluoropyrazole (20 g, 0.23 mol) in DMF (200 mL) 0 C. The mixture was stirred at room temperature for 1 h and then 2-bromo-ethanol (43 g, 0.35 mol) was added dropwisely at 0 C. The resulting mixture was stirred at 40 C. for 12 h. TLC (petroleum ether/EtOAc=1:1) indicated the reaction was complete. The mixture was quenched with saturated aqueous NH4Cl (200 mL). Then DMF was removed in vacuo and the residue was partitioned between Et2O (1000 mL) and H2O (1000 mL). The aqueous layer was extracted with more Et2O (4*1 L). The combined organic layers were dried over Na2SO4 and concentrated in vacuum to give compound 6c (20 g, 66%) as a yellow oil. 1H NMR (400 MHz, DMSO-d6) delta ppm 3.69 (t, J=5.56 Hz, 2H), 4.04 (t, J=5.56 Hz, 2H), 4.90 (br. s., 1H), 7.43 (d, J=4.29 Hz, 1H), 7.81 (d, J=4.55 Hz, 1H).

The chemical industry reduces the impact on the environment during synthesis 4-Fluoro-1H-pyrazole. I believe this compound will play a more active role in future production and life.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35277-02-2, name is 4-Fluoro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C3H3FN2

To a solution of C30 (222 mg, 0.539 mmol) in N,N-dimethylformamide (3 mL) were added cesium carbonate (528 mg, 1.62 mmol) and 4-fluoro-1H-pyrazole (69.6 mg, 0.809 mmol). The reaction mixture was stirred overnight at room temperature, and then at 50 C. for 3 hours, whereupon it was diluted with water and extracted with ethyl acetate (3*50 mL). The combined organic layers were dried over magnesium sulfate, filtered, concentrated in vacuo, and purified via chromatography on silica gel (Gradient: 10% to 65% ethyl acetate in heptane) to provide the product as a colorless oil. Yield: 148 mg, 0.455 mmol, 84%. LCMS m/z 326.4 [M+H]+. 1H NMR (400 MHz, CDCl3) delta 7.37 (d, J=5.1 Hz, 1H), 7.32 (d, J=4.3 Hz, 1H), 4.88-4.80 (m, 1H), 4.15 (dd, half of ABX pattern, J=10.0, 6.0 Hz, 1H), 4.10 (dd, half of ABX pattern, J=10.2, 4.7 Hz, 1H), 3.68-3.56 (br m, 2H), 3.37-3.26 (m, 2H), 2.28 (dd, half of ABX pattern, J=13.7, 8.6 Hz, 1H), 2.17 (dd, half of ABX pattern, J=13.5, 5.3 Hz, 1H), 1.80-1.59 (m, 3H), 1.59-1.49 (m, 1H), 1.44 (s, 9H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 35277-02-2.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35277-02-2 name is 4-Fluoro-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 35277-02-2

Sodium hydride (700 mg, 17.4 mmol, 60% dispersion in mineral oil was added to a solution of fluoropyrazole (1000 mg, 11.6 mmol) in DMF (7 mL) at room temperature. The mixture was stirred at room temperature for 40 min. The mixture was then canulated to a 1-bromo-2-chloroethane (2000 mg, 13.9 mmol, in 1 mL of DMF). The mixture was heated to 60 C. for 12 h. Water (50 mL) was added to the reaction mixture and THF (2*200 mL) was added to extract the aqueous solution. The combined organic layer was dried, filtered, and concentrated to get a waxy oil residue. LC/MS and 1H-NMR indicated it’s the mixture of two products, compound 4c and compound 4d (1000 mg, 57.4% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Fluoro-1H-pyrazole, and friends who are interested can also refer to it.

35277-02-2, A common compound: 35277-02-2, name is 4-Fluoro-1H-pyrazole, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Step 1: A stirred suspension of methyl (1S,8R)-12-bromo-15-oxatetracyclo-[6.6.1 .02?7.09?4jpentadeca-2,4,6,9, 11,1 3-hexaene-4-carboxylate (NT-3a1; 480,00 mg: 1.45mmol: 1.00 eq.), methylboronic acid (173.53 mg; 2.90 mmol; 2.00 eq.), cesium carbonate (1 180.65 mg; 3.62 mmol; 2.50 eq.) and 1,1 -bis(diphenylphosphino)ferrocenej dichloro palladium(II) (106.06 mg; 0.14 mmol; 0.10 eq.) in 1,4-dioxane (57.98 ml) and methanol (16.10 ml) was heated to 80 C. After 1 h the reacting mixture was cooled to RT, filtered withadditional MeOH and concentrated. The brown residue was purified by column chromatography (40 G ISCO Gold) eluting with 1 0/b EtOAc in heptane to provide the desired methyl (1 R,8S)- 12-methyl-i 5-oxatetracyclo[6.6. 1. 02?7.09?4jpentadeca-2.4,6,9, 11,13- hexaene-4-carboxylate contaminated by inseparable methyl (1 R.8 S) 15 -oxatetracyclo[6.6,1 ,02?7,09?4lpentadeca-2,4,6,9, 11,1 3-hexaene-4-carboxylate (320 mg), Step 2: To a stirred suspension of methyl (1R,8S)-12-methyl-15-oxatetracyclo- [6.6.1 .02?7.09?4jpentadeca-2,4,6,9, 11,1 3-hexaene-4-carboxylate and methyl (1 R,8S) 15- oxatetracyclo [6.6.1.027. 14j pentadeca-2,4,6,9, 11,1 3-hexaene-4-carboxylate (320.00 mg; 1.20 mmol; 1.00 eq.), and N-bromosuccinimide (224.58 mg; 1.26 mmol; 1.05 eq.) in carbon tetrachloride (12.02 ml) was added AIBN (9.87 mg; 0.06 mmol; 0.05 eq.). The resultingmixture was heated to 75 C. After 3 h the reacting mixture was cooled to RT diluted with DCM, washed with sat. NaHCO3, dried over MgSO4, filtered and concentrated. The crude material was purified by column chromatography (12 G ISCO Gold) eluting with 10% EtOAc in heptane to provide methyl (1S,8R)-12-(bromomethyl)-15-oxatetracyclo- [6.6.1.027. ue 14j pentadeca-2,4,6,9, 11,1 3-hexaene-4-carboxylate contaminated by inseparablemethyl (1 S,SR)-i 2-(dibromomethyl)- 1 5-oxatetracyclo[6. 6.1 .02?7.09?4jpentadeca-2,4,6,9,11,1 3-hexaene-4-carboxylate (273 mg).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Fluoro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

35277-02-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35277-02-2 name is 4-Fluoro-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Intermediate (11): 4-fluoro-1-(4-nitrophenyl)-1H-pyrazole To a solution of 4-fluoro-1H-pyrazole (250 mg, 2.90 mmol) and potassium carbonate (803 mg, 5.81 mmol) in acetonitrile (3 mL) was added 4-fluoronitrobenzene (430 mg, 3.05 mmol). The resulting mixture was stirred at 70 C. for 2 hours. The reaction was then filtered and concentrated. Purification by column chromatography gave 4-fluoro-1-(4-nitrophenyl)-1H-pyrazole (400 mg, 67%). 1H NMR (400 MHz, CDCl3, delta): 8.34 (d, 2H), 7.91 (d, 1H), 7.81 (d, 2H), 7.67 (d, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Fluoro-1H-pyrazole, and friends who are interested can also refer to it.