Reference of 35277-02-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35277-02-2, name is 4-Fluoro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.
Sodium hydride (13.8 g, 0.35 mol, 60% dispersion in mineral oil) was added to a solution of fluoropyrazole (20 g, 0.23 mol) in DMF (200 mL) 0 C. The mixture was stirred at room temperature for 1 h and then 2-bromo-ethanol (43 g, 0.35 mol) was added dropwisely at 0 C. The resulting mixture was stirred at 40 C. for 12 h. TLC (petroleum ether/EtOAc=1:1) indicated the reaction was complete. The mixture was quenched with saturated aqueous NH4Cl (200 mL). Then DMF was removed in vacuo and the residue was partitioned between Et2O (1000 mL) and H2O (1000 mL). The aqueous layer was extracted with more Et2O (4*1 L). The combined organic layers were dried over Na2SO4 and concentrated in vacuum to give compound 6c (20 g, 66%) as a yellow oil. 1H NMR (400 MHz, DMSO-d6) delta ppm 3.69 (t, J=5.56 Hz, 2H), 4.04 (t, J=5.56 Hz, 2H), 4.90 (br. s., 1H), 7.43 (d, J=4.29 Hz, 1H), 7.81 (d, J=4.55 Hz, 1H).
The chemical industry reduces the impact on the environment during synthesis 4-Fluoro-1H-pyrazole. I believe this compound will play a more active role in future production and life.