As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35277-02-2 name is 4-Fluoro-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 35277-02-2
Sodium hydride (700 mg, 17.4 mmol, 60% dispersion in mineral oil was added to a solution of fluoropyrazole (1000 mg, 11.6 mmol) in DMF (7 mL) at room temperature. The mixture was stirred at room temperature for 40 min. The mixture was then canulated to a 1-bromo-2-chloroethane (2000 mg, 13.9 mmol, in 1 mL of DMF). The mixture was heated to 60 C. for 12 h. Water (50 mL) was added to the reaction mixture and THF (2*200 mL) was added to extract the aqueous solution. The combined organic layer was dried, filtered, and concentrated to get a waxy oil residue. LC/MS and 1H-NMR indicated it’s the mixture of two products, compound 4c and compound 4d (1000 mg, 57.4% yield).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Fluoro-1H-pyrazole, and friends who are interested can also refer to it.