Category: pyrazoles-derivatives

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 37622-90-5 as follows. Application In Synthesis of Ethyl 4-pyrazolecarboxylate

General procedure: Step 1: Ethyl 1-(4-fluorobenzyl)-1H-pyrazole-4-carboxylate Sodium hydride (60% oil dispersion; (2.869 g, 71.7 mmol)) was added portion wise to a cold (0 C.) solution of ethyl 1H-pyrazole-4-carboxylate (6.7 g, 47.81 mmol) in DMF (70 mL). The mixture was stirred for 1 hour at 0 C. followed by the addition of 1-(bromomethyl)-4-fluoro-benzene (10.85 g, 57.38 mmol). The reaction was warmed to room temperature and stirred for 18 hours. The reaction mixture was poured into water and the resulting precipitate was collected by vacuum filtration, washed with water, and dried under vacuum at 50 C. for 20 hours to afford the title compound, wt. 8.3 g (70% yield); 1H NMR (400 MHz, DMSO-d6) delta 8.47 (d, J=0.7 Hz, 1H), 7.87 (d, J=0.7 Hz, 1H), 7.34 (dd, J=8.6, 5.6 Hz, 2H), 7.18 (t, J=8.9 Hz, 2H), 5.35 (s, 2H), 4.20 (q, J=7.1 Hz, 2H), 1.25 (t, J=7.1 Hz, 3H).

According to the analysis of related databases, 37622-90-5, the application of this compound in the production field has become more and more popular.

Electric Literature of 26621-44-3, A common heterocyclic compound, 26621-44-3, name is 3-Nitro-1H-pyrazole, molecular formula is C3H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under inert gas (eg high purity nitrogen) protection to 10 mlSchlek reaction tube was added 0.02 mmol of water-soluble palladium on water-bound monophosphine salt compound (18), 1.0 mmol of 4-methoxy-2-chloropyridine, 1.5 mmol of 3-nitropyrazole, 3 mmol of potassium carbonate and 5 ml of Water, the reaction tube was replaced with nitrogen three times, and then heated to 100 C with an oil bath under magnetic stirring, and the reaction was refluxed for 24 hours. The oil bath was removed and the reaction was concentrated with a rotary evaporator. The residue was chromatographed on silica gel using ethyl acetate as the developing solvent to give pure product 4-methoxy-2-pyridine-3-nitroPyrazole in 85% yield.

The synthetic route of 26621-44-3 has been constantly updated, and we look forward to future research findings.

Related Products of 51516-70-2,Some common heterocyclic compound, 51516-70-2, name is 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile, molecular formula is C10H7FN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The experimental procedure was similar to synthesis of analogs1(aei). 5-amino-1-aryl-1H-pyrazole-4-carbonitriles 4(aei)(0.001 mol) were reacted with 2.0 mL of 1,3-diaminopropane andcarbon disulfide (0.004 mol). The temperaturewas 85-95oC and thereaction time was 14-16 hours. The reaction mixture was pouredinto cold water, the precipitate was filtered out and washed withcold water. The reactions were accompanied by means of TLC anddichloromethane as eluent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2644-93-1, name is 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., category: pyrazoles-derivatives

Sodium triacetoxyborohydride (17.5 mg, 0.082 mmol) was added to a solution of piperidin-4-yl-benzothiazole (15 mg, 0.069 mmol, Compound 2h, Step 2) and 1,3,5- trimethyl-1H-pyrazole-4-carbaldehyde (9.5 mg, 0.069 mmol, Bionet) in DCE (340 .iL) at room temperature. After three hours, the reaction was purified directly by flash chromatography (4g silica, 0-10% MeOH/DCM). The title compound was obtained as a yellow solid (15 mg, 65% yield). LCMS (ESI) m/z 341.4 (M+1) retention time 3.2 mm. ?H NMR (300MHz, CD3OD) oe = 7.97-7.89 (m, 2H), 7.52-7.37 (m, 2H), 3.71 (s, 3H), 3.63 (s, 2H), 3.28-3.17 (m, 3H), 2.53 (dt,J=2.3, 11.7 Hz, 2H), 2.28 (s, 3H), 2.24 (m, 2H), 2.22 (s, 3H), 2.09-1.97 (m, 2H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1124-16-9, name is 5-Amino-1-isopropyl-3-methylpyrazole, A new synthetic method of this compound is introduced below., SDS of cas: 1124-16-9

Step 1 To a degassed solution of 2,5-dichloro-4-iodopyridine (8 g, 29.2 mmol), 2-amino-3-fluorobenzonitrile (3.98 g, 29.2 mmol) and potassium triphosphate (18.60 g, 88 mmol) in 1,4-dioxane (60 ml) stirred under nitrogen at the room temperature was added DPEPhos (1.258 g, 2.337 mmol) and palladium acetate (0.262 g, 1.168 mmol) The reaction mixture was stirred at reflux for 18 hr. The reaction mixture was filtered. 3-Methyl-1-(1-methylethyl)-1H-pyrazol-5-amine (4.07 g, 29.2 mmol) and cesium carbonate (28.6 g, 88 mmol) were added. The reaction mixture was degassed and palladium acetate (0.262 g, 1.168 mmol) and DPEPhos (1.258 g, 2.337 mmol) were added. The reaction mixture was refluxed overnight. The reaction mixture was filtered and the solid was dissolved in water, heated to 50 C. and stirred for 10 minutes, then filtered again. 2-[(5-Chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]-3-fluorobenzonitrile (6 g, 15.59 mmol, 53.4% yield) was isolated as an orange solid. 1H NMR (400 MHz, DMSO-d6) d ppm 1.23 (d, J=6.57 Hz, 6H) 2.07 (s, 3H) 4.32 (quin, J=6.57 Hz, 1H) 5.64 (d, J=2.02 Hz, 1H) 5.83 (s, 1H) 7.39-7.58 (m, 1H) 7.63-7.82 (m, 2H) 7.88 (s, 1H) 8.26 (br. s., 1H) 8.41 (br. s., 1H); HPLC Rt=2.35 min, MS (ESI): 385.0 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

1246471-38-4, name is Ethyl 3-Cyclopropylpyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 1246471-38-4

To a solution of 4,4,5,5-tetramethyl-2-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1,3,2-dioxaborolane (1.03 g, 2.45 mmol) in pyridine (5 mL) were added ethyl 3-cyclopropyl-1H-pyrazol-4-carboxylate (0.53 g, 2.94 mmol) and copper(II) acetate monohydrate (0.25 g, 1.23 mmol), and the mixture was stirred overnight at 55C. The reaction mixture was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate_hexane=1:4) to give ethyl 3-cyclopropyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxylate (990 mg, yield 86%) as a solid and ethyl 5-cyclopropyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxylate (20 mg, yield 2%) as an oil. ethyl 3-cyclopropyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxylate (Reference Example 26) 1H-NMR (CDCl3) delta: 1.00-1.10 (2 H, m), 1.10-1.18 (2 H, m), 1.39 (3 H, t, J = 7.2 Hz), 2.57-2.70 (1 H, m), 4.29 (2 H, s), 4.35 (2 H, q, J = 7.2 Hz), 7.02 (1 H, s), 7.33-7.41 (2 H, m), 7.41-7.56 (3 H, m), 7.56-7.64 (2 H, m), 8.41 (1 H, s). ethyl 5-cyclopropyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxylate (Reference Example 27) 1H-NMR (CDCl3) delta: 0.59-0.71 (2 H, m), 0.77-0.91 (2 H, m), 1.32-1.45 (3 H, m), 1.88-2.01 (1 H, m), 4.22-4.39 (4 H, m), 7.08 (1 H, s), 7.30-7.56 (6 H, m), 7.74 (1 H, d, J = 8.0 Hz), 8.07 (1 H, s).

The synthetic route of 1246471-38-4 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 139756-02-8, name is 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide, A new synthetic method of this compound is introduced below., name: 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide

General procedure: A mixture of 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide 1a (1.0 mmol), Ketones 2(1.0 mmol) and InCl3 (10 mol%,) in acetonitrile (6 mL) was stirred at room temperature for the time indicated in Table 3. After completion of the reaction (indicated by TLC) the reaction mixture was filtered and wash with acetonitrile (2 X 5 mL) to remove the insoluble catalyst. The filtrate was collected and concentrated under vacuum. The solid isolated was triturated with MTBE (10 mL), filtered and dried to give the desired product.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 718632-46-3, name is 5-tert-Butyl 2-ethyl 3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-2,5(4H,6H)-dicarboxylate, A new synthetic method of this compound is introduced below., Quality Control of 5-tert-Butyl 2-ethyl 3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-2,5(4H,6H)-dicarboxylate

Example 1; 6,6-Dimethyl-3-[4-(4-methyl-piperazin-l-yl)-benzoylamino]-4,6-dihydro-lH- pyrrolo[3,4-c]pyrazole-2,5-dicarboxylic acid 5-tert-butyl ester 2-ethyl ester [Formula (IV), R = 4-(4-methyl-piperazin)-phenyl]; To a solution of 3-Amino-6,6-dimethyl-4H,6H-pyrrolo[3,4-c]pyrazole-2,5- dicarboxylic acid 5-tert-butyl ester 2-ethyl ester (2.50 g, 7.70 mmol) prepared as reported in WO2004/056827, N,N-diispropylethylamine (14.6ml, 33.6mmol) in anhydrous Dioxane (100 ml), 4-(4-Methyl-piperazin-l-yl)-benzoyl chloride (0.24 g ,1.00 mmol) was added. The reaction was heated to reflux and stirred for 6h. The solvent was removed under vacuum, the residue dissolved in CH2Cl2 (150 mL) and washed with brine (I X 10OmL). The organic phase was dried over sodium sulphate, the solvent evaporated in vacuo and the residue purified by flash chromatography (Acetone/DCM 80/20) affording 2.1O g (yield 52%) of the title compound. ESI MS: m/z 527 (MH+); 1H NMR (400 MHz, DMSO-d6): delta 10.69 (s, IH), 7.76 (m, 2H), 7.09 (m, 2H), 4.55 (d, 2H, J = 9.8 Hz), 4.48 (q, 2H, J = 7.1 Hz), 3.34 (m, 4H), 2.52 (m, 4H), 2.27 (s, 3H ), 1.64 (s, 3H ), 1.62 (s, 3H ), 1.47 (s, 9H), 1.38 (t, 3H, J= 7.1 Hz).

The synthetic route of 718632-46-3 has been constantly updated, and we look forward to future research findings.

Electric Literature of 51985-95-6, These common heterocyclic compound, 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A) methyl 5-(4-((tert-butyl(dimethyl)silyl)oxy)phenoxy)-1-methyl-1H-pyrazole-3-carboxylate (1089) A mixture of 660 methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate (2.68 g), 661 (4-((tert-butyl(dimethyl)silyl)oxy)phenyl)boronic acid (4.33 g), 662 copper(II) acetate (4.69 g), 121 triethylamine (3.90 ml), molecular sieves 4A (5.5 g) and 110 dichloromethane (60 ml) was stirred at room temperature for 15 hr. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate) to give the 663 title compound (600 mg). 1H NMR (400 MHz, CDCl3) delta 0.20 (6H, s), 0.99 (9H, s), 3.83 (3H, s), 3.89 (3H, s), 6.03 (1H, s), 6.75-6.86 (2H, m), 6.95-7.05 (2H, m).

The synthetic route of 51985-95-6 has been constantly updated, and we look forward to future research findings.

Reference of 2075-46-9, A common heterocyclic compound, 2075-46-9, name is 4-Nitro-1H-pyrazole, molecular formula is C3H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 4-nitro- 1 H-pyrazole (5.0 g, 44.2 mmol) in CH3CN (100 ml) was added 1 -bromo-2-methoxyethane (4.15 ml, 44.2 mmol, 4.15 mL) and K2C03 (12.22 g, 88.4 mmol). The mixture was stirred at 80 C for 12 h. The solvent was removed under reduced pressure. The residue was diluted with water (30 ml) and extracted with EtOAc (3 x 50 ml), the organic layers were combined and washed with brine (20 ml), dried over Na2S04, and concentrated. The resulting residue was purified by FCC (10 – 25 % petroleum ether in ethyl acetate) to give the title compound as a colourless oil (Y = 79 %). H NMR (400 MHz, chlorofomwf) d ppm 8.24 (s, 1H), 8.08 (s, 1H), 4.32 (t, J= 5 Hz, 2H), 3.75 (t, J= 5 Hz, 2H), 3.36 (s, 3H).

The synthetic route of 2075-46-9 has been constantly updated, and we look forward to future research findings.