Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2644-93-1, name is 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., category: pyrazoles-derivatives
Sodium triacetoxyborohydride (17.5 mg, 0.082 mmol) was added to a solution of piperidin-4-yl-benzothiazole (15 mg, 0.069 mmol, Compound 2h, Step 2) and 1,3,5- trimethyl-1H-pyrazole-4-carbaldehyde (9.5 mg, 0.069 mmol, Bionet) in DCE (340 .iL) at room temperature. After three hours, the reaction was purified directly by flash chromatography (4g silica, 0-10% MeOH/DCM). The title compound was obtained as a yellow solid (15 mg, 65% yield). LCMS (ESI) m/z 341.4 (M+1) retention time 3.2 mm. ?H NMR (300MHz, CD3OD) oe = 7.97-7.89 (m, 2H), 7.52-7.37 (m, 2H), 3.71 (s, 3H), 3.63 (s, 2H), 3.28-3.17 (m, 3H), 2.53 (dt,J=2.3, 11.7 Hz, 2H), 2.28 (s, 3H), 2.24 (m, 2H), 2.22 (s, 3H), 2.09-1.97 (m, 2H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.