Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 718632-46-3, name is 5-tert-Butyl 2-ethyl 3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-2,5(4H,6H)-dicarboxylate, A new synthetic method of this compound is introduced below., Quality Control of 5-tert-Butyl 2-ethyl 3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-2,5(4H,6H)-dicarboxylate
Example 1; 6,6-Dimethyl-3-[4-(4-methyl-piperazin-l-yl)-benzoylamino]-4,6-dihydro-lH- pyrrolo[3,4-c]pyrazole-2,5-dicarboxylic acid 5-tert-butyl ester 2-ethyl ester [Formula (IV), R = 4-(4-methyl-piperazin)-phenyl]; To a solution of 3-Amino-6,6-dimethyl-4H,6H-pyrrolo[3,4-c]pyrazole-2,5- dicarboxylic acid 5-tert-butyl ester 2-ethyl ester (2.50 g, 7.70 mmol) prepared as reported in WO2004/056827, N,N-diispropylethylamine (14.6ml, 33.6mmol) in anhydrous Dioxane (100 ml), 4-(4-Methyl-piperazin-l-yl)-benzoyl chloride (0.24 g ,1.00 mmol) was added. The reaction was heated to reflux and stirred for 6h. The solvent was removed under vacuum, the residue dissolved in CH2Cl2 (150 mL) and washed with brine (I X 10OmL). The organic phase was dried over sodium sulphate, the solvent evaporated in vacuo and the residue purified by flash chromatography (Acetone/DCM 80/20) affording 2.1O g (yield 52%) of the title compound. ESI MS: m/z 527 (MH+); 1H NMR (400 MHz, DMSO-d6): delta 10.69 (s, IH), 7.76 (m, 2H), 7.09 (m, 2H), 4.55 (d, 2H, J = 9.8 Hz), 4.48 (q, 2H, J = 7.1 Hz), 3.34 (m, 4H), 2.52 (m, 4H), 2.27 (s, 3H ), 1.64 (s, 3H ), 1.62 (s, 3H ), 1.47 (s, 9H), 1.38 (t, 3H, J= 7.1 Hz).
The synthetic route of 718632-46-3 has been constantly updated, and we look forward to future research findings.