Category: pyrazoles-derivatives

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 37622-90-5, name is Ethyl 4-pyrazolecarboxylate, A new synthetic method of this compound is introduced below., Formula: C6H8N2O2

To a solution of ethyl 1H-pyrazole-4-carboxylate (31 g) and sodium acetate (120 g) in a mixed solvent of ethanol (200 mL) and water (300 mL) was added bromine (140 g), and the mixture was stirred at room temperature for 10 hr. To the reaction mixture was added sodium thiosulfate (180 g), and the mixture solvent was evaporated under reduced pressure. The reaction mixture was poured into water, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (65 g). (1090) MS (ESI+): [M+H]+ 296.7

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 5203-77-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5203-77-0, name is 1,3-Dimethyl-1H-pyrazol-5-ol belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

200 mg (0.71 mmol) of 2-methyl-3-methylsulfonyl-4-trifluoromethylbenzoic acid together with 87 mg (0.78 mmol) of 5-hydroxy-1,3-dimethylpyrazole and a catalytic amount of 4-N,N-dimethylaminopyridine were initially charged in 20 ml of dry CH2Cl2, and 163 mg (0.85 mmol) of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride were added. The mixture was stirred at RT for 3 h, and 3 ml of 1 M HCl were then added. After phase separation, the aqueous phase was extracted with CH2Cl2. The organic phases were dried and concentrated. The residue was taken up in 20 ml of acetonitrile and 143 mg (1.42 mmol) of triethylamine, and eight drops of acetone cyanohydrine and a spatula tip of KCN were added. The mixture was stirred at RT for 16 h and concentrated. 15 ml of CH2Cl2 and then 2 ml of 1M HCl were added to the residue. After phase separation, the aqueous phase was extracted with CH2Cl2. The combined organic phases were dried and concentrated. The residue was purified chromatographically. What was isolated were 112.7 mg of pure product.

The synthetic route of 1,3-Dimethyl-1H-pyrazol-5-ol has been constantly updated, and we look forward to future research findings.

Synthetic Route of 64781-79-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 64781-79-9, name is 4-Methyl-1H-pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows.

Compound 6 (40 mmol) was dissolved in DMF (100 mL), then 4-methyl-2-aminopyrazole(44 mmol), sodium iodide (48 mmol) and diisopropylethylamine (DIPEA) (48 mmol). the solution was heated to 100 deg.] C, overnight,then cooled to room temperature, diluted with ethyl acetate (200 mL), saturated sodium bicarbonate solution (3 ¡Á 200mL), dried and reducedpressure concentrated and purified by flash chromatography on silica gel, washing wherein release agent, 0% to 4% methanol / dichloromethane to give a white-basedcolor solid 10- (sec-butyl) -5 – ((4-methyl -1H- pyrazol-3-yl) amino) -7 – oxo -2,3,7,10- tetrahydro – [1,4]dioxin [2], 3-H] quinoline-8-carboxylate, 15.09g, yield 91.5%,

The chemical industry reduces the impact on the environment during synthesis 4-Methyl-1H-pyrazol-3-amine. I believe this compound will play a more active role in future production and life.

Electric Literature of 15801-69-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15801-69-1, name is 4-Bromo-1,3,5-trimethyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of 4-methyl-3-(4-(pyridin-2-ylmethoxy)benzamido)phenyl boronic acid (50 mg, 0.14 mmol), Cs2CO3 (135 mg, 0.41 mmol), Pd(PPh3)4(23.93 mg, 0.02 mmol) and 4-bromo-1H-imidazole (26 mg, 0.18 mmol) was purged with nitrogen before adding degassed dioxane (690 muL) and water (230 muL) and heating in a microwave for 40 min at 150 C. After cooling, the aqueous layer was removed with a pipette, and the organic layer was diluted with DMSO (1 mL) and filtered through a 0.2 mum filter. The filtrate was concentrated to a volume of 1 mL and purified by Gilson HPLC (20-75% MeCN/10 mM NH4OAc in water). The fractions were concentrated and lyophilized to yield the product (19 mg, 0.049 mmol, 35%). 1H NMR (DMSO-d6) delta ppm 12.11 (s, 1H), 9.76 (s, 1H), 8.59 (d, 1H), 7.97 (d, 2H), 7.85 (td, 1H), 7.70 (s, 1H), 7.67 (s, 1H), 7.56 (m, 2H), 7.36 (dd, 1H), 7.21 (d, 1H), 7.15 (d, 2H), 5.27 (s, 2H), 2.18 (s, 3H). LCMS (M+H) = 385.

The synthetic route of 4-Bromo-1,3,5-trimethyl-1H-pyrazole has been constantly updated, and we look forward to future research findings.

Application of 1904-31-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

2-Bromo-5-cyclopentyloxy-pyridine (0.97 mmol), sodium-tert.- butylate (1.4 eq.), and 1-methyl-1 H-pyrazole-3-amine (1.2 eq.) are dissolved in degassed dioxane (2 ml) and heated to 80 0C. Chloro-(di-2- norbornylphosphino)(2-dimethylaminoferrocene-1-yl)palladium (II) (3 mg) in degassed dioxane (1 ml) is added and the reaction mixture is heated for 1 hour at 150 0C in the microwave. The reaction is quenched with ethylacetate / methanol (30 ml, 9:1 ) and filtrated over celite. The solvent of the filtrate is removed in vacuo. (5-Cyclopentyloxy-pyridine-2-yl)-(1-methyl- 1 H-pyrazole-3-yl)-amine (“A25”) is obtained after reversed phase column chromatography (water / acetonitrile + 0.1 percent TFA) as a colorless powder in a yield of 29 percent; HPLC (method C): 1.55 min; LC-MS (method A): 0.97 min, 259.15 (M+H+); 1H-NMR (DMSO-Cl6, 400 MHz): delta [ppm] 10.745 (s, 1 H), 7.848 (d, 1 H, J=2.9 Hz), 7.739-7.709 (m, 2H), 7.282 (of, 1 H, J=9.6 Hz)1 6.091 (d, 1 H, J=2.3 Hz), 4.793-4.764 (m, 1 H), 3.850 (s, 3H), 1.953-1.865 (m, 2H), 1.751-1.688 (m, 4H), 1.661-1.583 {m, 2H).

The synthetic route of 1-Methyl-1H-pyrazol-3-amine has been constantly updated, and we look forward to future research findings.

Reference of 73387-46-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 73387-46-9 name is 3-(4-Bromophenyl)-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[0001228] A mixture of 3-(4-bromophenyl)-lH-pyrazole (1.0 g, 4.5 mmol), cyclopropylboronic acid (0.8 g, 9 mmol), Cu(OAc)2 (1.6 g, 9 mmol), Na2C03 (0.9 g, 9 mmol), bipyridine (1.4 g, 9 mmol), and 4 A molecular sieve powder (5 g) in 1,2- dichloroethane (20 mL) was stirred at 30 C for 72 h. After filtration, the mixture was diluted with dichloromethane (50 mL), washed with water (30 mL x 2) and brine (50 mL), dried over anhydrous sodium sulfate, and concentrated to give a crude compound. The crude product was purified with flash column chromatography on silica gel (ethyl acetate in petroleum ether, from 0% to 10% v/v) to afford Compound 349A.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(4-Bromophenyl)-1H-pyrazole, and friends who are interested can also refer to it.

Related Products of 127107-23-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, This compound has unique chemical properties. The synthetic route is as follows.

4- ( (IS, 2R) -2- ( (tert-Butoxycarbonyl) amino) cyclopropyl) -5- methylthiophene-2-carboxylic acid (3.06 g) , 1-methyl.-1H- pyrazol-4-amine hydrochloride (1.37 g) and triethylamine (5.73 mL) were dissolved in DMF (30 mL) , 0- (7-azabenzotriazol-l-yl) – Nu,Nu,Nu’ ,Nu’ -tetramethyluronium hexafluorophosphate (4.69 g) was added, and the mixture was stirred at 40C overnight. Water was added to the reaction mixture, and the mixture wasextracted with ethyl acetate. The extract was washed with saturated aqueous sodium hydrogen carbonate solution, water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate and methanol/ethyl acetate) to give the title compound (3.7 g) .MS: [M+H]+377.1

The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-pyrazol-4-amine hydrochloride. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31037-02-2, name is Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., COA of Formula: C7H11N3O2

INTERMEDIATE 1 Ethyl 5 – [(3 -ethoxy-3 -oxopropanoyQamino] – 1 -methylpyrazole-4-carboxylate A solution of ethyl 5-amino-l-methylpyrazole-4-carboxylate (5 g, 29.6 mmol) in diethyl malonate (9 mL, 59.2 mmol) was heated at 180C overnight, then for a further 6 h at 200C. After this time, the reaction mixture was cooled and concentrated in vacuo, then purified by normal phase chromatography (Si02, 50% EtO Ac/heptane to 100% EtO Ac), to yield the title compound (4.12 g, 49%) as a pale yellow oil that crystallised on standing. deltaEta (CDC13) 9.70 (br s, 1H), 7.79 (s, 1H), 4.27 (2 x q, J 6.8 Hz, 4H), 3.75 (s, 3H), 3.50 (s, 2H), 1.32 (2 x t, J 7.4 Hz, 6H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Some common heterocyclic compound, 31037-02-2, name is Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, molecular formula is C7H11N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 31037-02-2

Triethylamine (0.49 ml, 3.5 mmol) was added to a stirred solution of ethyl 5-amino-1-methyl-pyrazole-4- carboxylate (0.50 g, 3.0 mmol) in dichloromethane (30 ml) at 0C. After 5 minutes methanesulfonyl chloride (0.23 ml, 3.0 mmol) was added dropwise. The resulting mixture was allowed to warm to room temperature over 18 hours and then partitioned between 1 M hydrochloric acid and dichloromethane. Thephases were separated and the aqueous extracted with further dichloromethane. The combined organic phases were passed through a PhaseSep cartridge and concentrated under reduced pressure to leave ethyl 5-(methanesulfonamido)-1-methyl-pyrazole-4-carboxylate, which was used without further purification. Characterising data for the compound are as follows: 1H NMR (400 MHz, CDCI3) oe 7.97 (s, 1 H), 4.34 (t,2H), 3.92 (s, 3H), 3.51 (s, 3H) and 1.36 (t, 3H) ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 31037-02-2, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16461-94-2, name is 4-Bromo-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., name: 4-Bromo-1H-pyrazol-3-amine

A solution of the amino-bromo-pyrazole obtained above, dissolved in EtOH (23OmL) was treated with cone. HCl (13.6mL) followed by tetra-methoxypropane (3 ImL) at rt. The resulting turbid solution was heated to 71C for 2h, during this time, the reaction mixture turned into a suspension and a solid started separating out. The reaction mixture was cooled to rt, the precipitated solid was collected by filtration, washed with EtOH (min vol.) and dried to obtain the desired compound. The crude compound (C) was used as such for the next step without further purification (26.8 g, 74.1%). (M + H): 198.0.

The synthetic route of 16461-94-2 has been constantly updated, and we look forward to future research findings.