Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31037-02-2, name is Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., COA of Formula: C7H11N3O2
INTERMEDIATE 1 Ethyl 5 – [(3 -ethoxy-3 -oxopropanoyQamino] – 1 -methylpyrazole-4-carboxylate A solution of ethyl 5-amino-l-methylpyrazole-4-carboxylate (5 g, 29.6 mmol) in diethyl malonate (9 mL, 59.2 mmol) was heated at 180C overnight, then for a further 6 h at 200C. After this time, the reaction mixture was cooled and concentrated in vacuo, then purified by normal phase chromatography (Si02, 50% EtO Ac/heptane to 100% EtO Ac), to yield the title compound (4.12 g, 49%) as a pale yellow oil that crystallised on standing. deltaEta (CDC13) 9.70 (br s, 1H), 7.79 (s, 1H), 4.27 (2 x q, J 6.8 Hz, 4H), 3.75 (s, 3H), 3.50 (s, 2H), 1.32 (2 x t, J 7.4 Hz, 6H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.