Tag: M.W:200-300

Adding a certain compound to certain chemical reactions, such as: 155600-99-0, name is 3,5-Dibromo-1-methyl-4-nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 155600-99-0, Quality Control of 3,5-Dibromo-1-methyl-4-nitro-1H-pyrazole

Nucleophilic aromatic substitution of the compound 2 with benzylamine in DMSO produces benzyl-(5-bromo-2-methyl-4-nitro-2H-pyrazol-3-yl)-amine 3.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Related Products of 39806-90-1, These common heterocyclic compound, 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To solution of Weinreb amide 10c (8.00 g, 15.4 mmol, 1.0 equiv.) in THF (180 mL) is added 4-iodo-1-methylpyrazole (12.8 g, 61.6 mmol, 4.0 equiv.). The solution is cooled to -78 C, a solution of tert-butyllithium (1.7 M in pentane, 37 mL, 4. equiv.) is added dropwise and the reaction is stirred for 45 min. The reaction mixture is poured into aqueous NH4Cl (saturated) and extracted with EtOAc. After isolation of organic phase, silica is added and the solid residue is purified by chromatography using MeOH in DCM to give the desired product 12b. (6.20 g, 74%)

The synthetic route of 39806-90-1 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 51516-70-2, name is 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile, molecular formula is C10H7FN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C10H7FN4

5-Amino-i -(4-fluorophenyl)-i H-pyrazole-4-car- boxamide (Step 1, 900 mg, 4.45 mmol) was added dropwise to sulfuric acid (10 mE) at 0 C. The resulting solution was stirred for 2 hat 25 C. The pH of the solution was adjusted to 8 by the addition of sodium carbonate (10% aqueous). The resulting mixture was extracted with dichloromethane (4×50 mE) and the organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under vacuum to provide 5-amino-i -(4-fluorophenyl)- 1H-pyrazole-4-car- boxamide which was used in Step 3 without further purification. ECMS: (ESI) mlz 221 [M+H].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 51516-70-2, its application will become more common.

Reference of 3528-45-8, These common heterocyclic compound, 3528-45-8, name is 1-(4-Methoxybenzyl)-1H-pyrazol-5-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 4: Synthesis of 3-(4-methoxybenzyl)-9-(methylsulfanyl)-6,7-dihydro-3H- pyrazolo[4′,3′:5,6]pyrido[4,3-f]quinazoline. To a mixture of (E)-6- ((dimethylamino)methylene)-2-(methylthio)-7,8-dihydroquinazolin-5(6H)-one (8 g, 32 mmol) and l-(4-methoxybenzyl)-lH-pyrazol-5 -amine (7.2 g, 35 mmol) was added trifluoroacetic acid (3 mL). The reaction mixture was heated at 100 0C for 16 hours. The reaction was cooled to room temperature and diluted with a 1 : 1 mixture of methanol and isopropanol (40 mL). The mixture was stirred for 30 minutes and filtered. The solid obtained was then further purified using flash column chromatography (SiO2, gradient from 100% chloroform to 2% EtOAc in chloroform) to give the desired product (3.0 g, 24%) as a yellow solid. 1H NMR (CDCl3, 400MHz): delta 9.52 (s, IH), 7.98 (s, IH), 7.82 (s, IH), 7.40 (d, J = 8.0 Hz, 2H), 6.82 (d, J = 8.0 Hz, 2H), 5.64 (s, 2H), 3.78 (s, 3H), 3.16 (t, J = 6.0 Hz, 2H), 3.10 (t, J = 6.2 Hz, 2H), 2.65 (s, 3H); LCMS [M+H]: 390.

The synthetic route of 3528-45-8 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 56426-35-8, name is Methyl 5-phenyl-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., name: Methyl 5-phenyl-1H-pyrazole-3-carboxylate

Intermediate 96 (320mg, 1.58mmol) was dissolved in THF/water (15mL, 1 :1), lithium hydroxide monohydrate (146mg, 3.48mmol) was added and the reaction mixture was stirred for 2h. The THF was removed in vacuo and the aqueous solution was acidified to pH 1 with 1M aq HCl. The precipitate was collected by filtration to give the title compound (232mg, 78%) as a yellow solid. LCMS: ES+ 189.0 [MH]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 1029413-51-1, name is 4-Amino-1-(1-boc-azetidin-3-yl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1029413-51-1, Quality Control of 4-Amino-1-(1-boc-azetidin-3-yl)-1H-pyrazole

General procedure: [0 140j To a solution of tert-butyl 2-methyl-4-(4,4,5 ,5 -tetramethyl- 1,3 ,2-dioxaborolan-2- yl)benzylcarbamate (3.47 g, 10 mmol) and 2,4-dichloropyrimidine (1.79 g, 12 mmol) in 1,4- dioxane (28 mL) and H20 (7 mL), Pd(dppf)C12.DCM (815 mg, 1.0 mmol) and K2C03 (2.76 g,mmol) were added under N2. The mixture was stirred at 90 C for 2 h. After cooling to rt, the mixture was diluted with H20 (80 mL) and extracted with EA (80 mL x2). The organic layers were dried and concentrated. The residue was purified by column chromatography (silica,petroleum ether/EtOAc = 5:1 to 2:1) to give tert-butyl 4-(2-chloropyrimidin-4-yl)-2- methylbenzylcarbamate (2.67 g, yield 80%) as white solid. [0231j Synthesis of tert-butyl 3 -(4-((4-(4-((2-(tert-butyl)thiazole-5 – carboxamido)methyl)-3 -methylphenyl)pyrimidin-2-yl)amino)- 1 H-pyrazol- 1 -yl)azetidine- 1- carboxylate was similar to that of tert-butyl 4-(2-chloropyrimidin-4-yl)-2- methylbenzylcarbamate. Purified through silica gel column chromatography with (MeOH/DCM= 1/20) to give tert-butyl 3 -(4-((4-(4-((2-(tert-butyl)thiazole-5 – carboxamido)methyl)-3 -methylphenyl)pyrimidin-2-yl)amino)- 1 H-pyrazol- 1 -yl)azetidine- 1- carboxylate (150 mg, yield: 69%) as a yellow solid. ESI-MS (M+H) : 603.2. ?H NMR (400 MHz, CDC13) (5: 8.45 (d, J= 5.2 Hz, iH), 8.i2 (s, iH), 8.05 (s, iH), 7.88 (s, iH), 7.85 (d, J 8.0 Hz, iH), 7.64 (s, iH), 7.42 (d, J= 8.0 Hz, iH), 7.10 (d, J 5.6 Hz, iH), 6.94 (s, iH), 6.i 1-6.09 (m, iH), 5.08-5.01 (m, iH), 4.68 (d, J= 5.2 Hz, 2H), 4.42-4.33 (m, 4H), 2.46 (s, 3H), 1.56 (s,

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Amino-1-(1-boc-azetidin-3-yl)-1H-pyrazole, and friends who are interested can also refer to it.

Electric Literature of 37687-24-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

N-iodosuccinimide (0.6 g, 2.59 mmol) was added to a solution of diethyl 3,5- pyrazoledicarboxylate (0.5 g, 2.35 mmol) in CHCI3 (10 mL) and the mixture was stirred at 80 C for 24 hours. Then more of N-iodosuccinimide (0.6 g, 2.59 mmol) was added and the mixture was stirred at 100 C for 48 hours more. Then the mixture was stirred at room temperature for 5 days. Then the mixture was treated with a saturated solution of Na2S203 and extracted with DCM. The organic layer was separated, dried (MgS04), filtered and the solvents evaporated in vacuo. The crude product was purified by flash columnchromatography (silica; MeOH in DCM 0/100 to 10/90). The desired fractions were collected and the solvents evaporated in vacuo to yield 4-iodo-lH-pyrazole-3,5-dicarboxylic acid diethyl ester (0.83 g, 90% yield).

The synthetic route of Diethyl 3,5-pyrazoledicarboxylate has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 83-10-3, name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid, A new synthetic method of this compound is introduced below., Application In Synthesis of 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid

To a solution of 4-((7-methoxyquinolin-4-yl)oxy)aniline (4 g, 15 mmol) and l,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-lH-pyrazole-4-carboxylic acid (3.56 g, 18 mmol) in CH2C12 (42 mL) was added HOAT (0.41 g, 3 mmol) at 43 C. The reaction was stirred at 43 C overnight, then cooled to rt and diluted with CH2CI2 (42 mL). The organic phase was separated, washed with water (42 mL x 2), dried over Na2S04 and concentrated in vacuo. The residue was stirred in EtOH aqueous solution (20 mL of EtOH in 20 mL of water) at rt for 3 h and collected through filtration to afford the title compound as a light yellow solid (5.6 g, 77.6%). MS (ESI, pos, ion) m/z: 481.0 [M+H]+; NMR (400 MHz, CDC13): delta 2.80 (s, 3H), 3.36 (s, 3H), 3.96 (s, 3H), 6.45 (d, J= 5.3 Hz, 1H), 7.11-7.13 (m, 2H), 7.20 (dd, J= 2.5 Hz, 9.2 Hz, 1H), 7.35 (t, J= 1.1 Hz, 2.2 Hz, 1H), 7.38 (d, J= 1.4 Hz, 1H), 7.41 (d, J= 2.5 Hz, 1H), 7.46-7.49 (m, 1H), 7.55 (t, J= 7.3 Hz, 15.2 Hz, 2H), 7.75 (dd, J= 2.1 Hz, 6.8 Hz, 2H), 8.24 (d, J = 9.2 Hz, 1H), 8.57 (d, J= 5.3 Hz, 1H), 10.77 (s, 1H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 70951-85-8, name is 4-Bromo-1-(tert-butyl)-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., category: pyrazoles-derivatives

To a -78 0C solution of 4-bromo-l -7-butyI-lH-pyrazole (15 g, 74.3 mmol) in anhydrous THF (100 mL) was added /7-BuLi (2.5 M in hexane, 53 mL, 132 mmol) under N2, and the resulting mixture was stirred at -78¡ãC for 30 min. Excess dry ice was added at -78 0C, and the mixture was warmed slowly to RT and stirred overnight. The reaction was concentrated in vacuo, water was added and the pH was adjusted to pH 3 by the addition of 2N aq HCI. The aqueous solution was extracted with EtOAc. The extracts were washed with brine, dried (MgSO4) and concentrated in vacuo. The residue was recrystallized (EtO Ac-pet, ether) to give 1 -/-butyl- lH-pyrazole-4-carboxylic acid (8.0 g, 67 percent yield). 1H NMR (300 MHz, CDCl3): ^ 8.10 (s, 1 H), 8.03 (s, 1 H), 1.64 (s, 9 H); MS (ESI) m/z: 168.9 [M+Hf.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 70951-85-8.