Some common heterocyclic compound, 51516-70-2, name is 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile, molecular formula is C10H7FN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C10H7FN4
5-Amino-i -(4-fluorophenyl)-i H-pyrazole-4-car- boxamide (Step 1, 900 mg, 4.45 mmol) was added dropwise to sulfuric acid (10 mE) at 0 C. The resulting solution was stirred for 2 hat 25 C. The pH of the solution was adjusted to 8 by the addition of sodium carbonate (10% aqueous). The resulting mixture was extracted with dichloromethane (4×50 mE) and the organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under vacuum to provide 5-amino-i -(4-fluorophenyl)- 1H-pyrazole-4-car- boxamide which was used in Step 3 without further purification. ECMS: (ESI) mlz 221 [M+H].
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 51516-70-2, its application will become more common.