Related Products of 39806-90-1, These common heterocyclic compound, 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To solution of Weinreb amide 10c (8.00 g, 15.4 mmol, 1.0 equiv.) in THF (180 mL) is added 4-iodo-1-methylpyrazole (12.8 g, 61.6 mmol, 4.0 equiv.). The solution is cooled to -78 C, a solution of tert-butyllithium (1.7 M in pentane, 37 mL, 4. equiv.) is added dropwise and the reaction is stirred for 45 min. The reaction mixture is poured into aqueous NH4Cl (saturated) and extracted with EtOAc. After isolation of organic phase, silica is added and the solid residue is purified by chromatography using MeOH in DCM to give the desired product 12b. (6.20 g, 74%)
The synthetic route of 39806-90-1 has been constantly updated, and we look forward to future research findings.