Tag: M.W:200-300

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 285984-25-0, name is 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C14H19N3

To a suspension of CDI (973 mg, 6.0To a suspension of CDI (973 mg, 6.00 mmol) in dry DCM (10.0 mL) under N2 was added Intermediate A1 (1.38 g, 6.00 mmol) as a solid, in four equal portions, over 10 min and the resulting solution maintained at RT for 16 hr. An aliquot of this solution (247 muL, 0.148 mmol) was added to a suspension of Intermediate J3 (50 mg, 0.16 mmol) in dry DCM (5.0 mL) and the reaction mixture kept at RT for 5 hr. The resulting suspension was diluted with DCM (5.0 mL) and the solid was collected by filtration and then suspended in water (5.0 mL) and sonicated for 3 min. The solid was collected by filtration, washed with water (2¡Á2.5 mL) and dried in vacuo at 45 C. for 16 hr to afford the title compound, Example 21, as a white solid (70 mg, 74%); Rt 4.67 min (Method 1 basic); m/z 579 (M+H)+ (ES+); 1H NMR (400 MHz, DMSO-d6) delta: 1.27 (9H, s), 2.39 (3H, s), 2.72 (3H, d), 5.31 (2H, s), 6.35 (1H, s), 7.08 (1H, dd), 7.20 (1H, d), 7.36 (2H, m), 7.43-7.45 (3H, overlapping m), 7.60 (1H, dd), 7.64 (1H, d), 8.14 (1H, br s), 8.19 (1H, d), 8.27 (1H, dd), 8.58 (1H, br s), 8.89 (1H, br s), 8.92 (1H, dd), 9.33 (1H, br s).0 mmol) in dry DCM (10.0 mL) under N2 was added Intermediate A1 (1.38 g, 6.00 mmol) as a solid, in four equal portions, over 10 min and the resulting solution maintained at RT for 16 hr. An aliquot of this solution (247 muL, 0.148 mmol) was added to a suspension of Intermediate J3 (50 mg, 0.16 mmol) in dry DCM (5.0 mL) and the reaction mixture kept at RT for 5 hr. The resulting suspension was diluted with DCM (5.0 mL) and the solid was collected by filtration and then suspended in water (5.0 mL) and sonicated for 3 min. The solid was collected by filtration, washed with water (2¡Á2.5 mL) and dried in vacuo at 45 C. for 16 hr to afford the title compound, Example 21, as a white solid (70 mg, 74%); Rt 4.67 min (Method 1 basic); m/z 579 (M+H)+ (ES+); 1H NMR (400 MHz, DMSO-d6) delta: 1.27 (9H, s), 2.39 (3H, s), 2.72 (3H, d), 5.31 (2H, s), 6.35 (1H, s), 7.08 (1H, dd), 7.20 (1H, d), 7.36 (2H, m), 7.43-7.45 (3H, overlapping m), 7.60 (1H, dd), 7.64 (1H, d), 8.14 (1H, br s), 8.19 (1H, d), 8.27 (1H, dd), 8.58 (1H, br s), 8.89 (1H, br s), 8.92 (1H, dd), 9.33 (1H, br s).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 285984-25-0.

Application of 187998-35-2, These common heterocyclic compound, 187998-35-2, name is 1-(4-Chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of l-(4-chloro-phenyl)-5-methyl-lH-pyrazole-4-carboxylic acid (1.5 g, 6.3 mmol) in thionyl chloride (18 rnL) is warmed to reflux for 1 hour. After cooling to room temperature, the reaction mixture is concentrated in vacuo to afford l-(4-chloro-phenyl)- 5-methyl-lH-pyrazole-4-carbonyl chloride as a tan solid (1.6 g, 100 %) which is used without further purification.

The synthetic route of 187998-35-2 has been constantly updated, and we look forward to future research findings.

Reference of 277299-70-4, A common heterocyclic compound, 277299-70-4, name is 2-(3,4-Dimethylphenyl)-5-methyl-1H-pyrazol-3(2H)-one, molecular formula is C12H14N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

200 ml of 2 mol/L hydrochloric acid was added to the reaction vessel.750ml of ethanol,50 g (0.26 mol) of 2-amino-6-bromophenol,Stir well,Cool down to 0 ~ 10 C,Slowly add sodium nitrite solution [18g (0.26mol) sodium nitrite dissolved in 50ml water],Temperature control does not exceed 10 C,Completion of the dropwise addition, the reaction at 5 ~ 10 1.5 ~ 2h,The reaction solution was allowed to rise to room temperature.Add triethylamine to adjust the pH of the reaction solution to 7-8.Further, 54 g (0.26 mol) of the compound of the formula (III) is added.The reaction was continued at 20 to 30 C for 2 hours.At the end of the reaction, the pH of the reaction solution was adjusted to 1-2 with 2 mol/L hydrochloric acid, the solid was precipitated, filtered, and the filter cake was washed with a mixture of ethanol/water (1:1), and the filter cake was dried under vacuum at 45 C.A dark red solid was obtained in 104.5 g (IV), yield 98%, and purity 99.562%.

The synthetic route of 277299-70-4 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 285984-25-0, name is 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine, molecular formula is C14H19N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine

General procedure: A solution of compounds 10a-d or compounds 17a-d (1.0 mmol) in dichloromethane (10 mL) was slowly added to a stirred solution of triphosgene (109 mg, 0.36 mmol) in dichloromethane (50 mL) over a period of 30 min using a syringe. After stirring for a further 30 min, a solution of compound 25a-r (0.6 mmol) and triethylamine (0.4 mL, 2.77 mmol) in dichloromethane (10 mL) was added in one portion. The reaction mixture was stirred for 2 h at room temperature. After completion of the reaction, the reaction was poured into water (50 mL) and extracted three times with dichloromethane. The organic layer was washed with water (5 mL), sat. NaCl solution (5 mL), anddried over Na2SO4. After evaporation of solvent under vacuum, the residue was purified by silica gel chromatography to give the desired chromanylurea or 2H-chromenyl urea compounds.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 285984-25-0, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 345637-71-0, name is 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 345637-71-0, Recommanded Product: 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid

Example 2: This example illustrates the preparation of 3-chloro-2-hydroxy-N-(3-{4-[2-(5- methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperazin-1-yl}-phenyl)-benzamide (Compound No. I.ao.003) a) Preparation of 2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-1-[4-(3-nitro-phenyl)- piperazin-1-yl]-ethanoneTo a solution of (5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetic acid (1.1 g, 5.28 mmol) in DMF (10 mL) is added triethylamine (1.47 mL, 10.57 mmol), followed by 1-hydroxy-7- benzotriazole (0.755 g, 5.55 mmol) and 1-ethyl-3-(3-dimethyllaminopropyl)carbodiimide hydrochloride (1.06 g, 5.55 mmol). After stirring 15 min at RT, 1-(3-nitro-phenyl)-piperazine (1.09 g, 5.28 mmol) is added to the reaction mixture. After stirring overnight at RT, solvent is evaporated and the resulting yellow oil is dissolved in ethylacetate (20 mL), washed with saturated aqueous sodium bicarbonate solution (50 mL), and brine (50 mL). The organic layer is dried over sodium sulfate, filtered, and evaporated under reduced pressure. The crude mixture is purified by column chromatography on silica gel (cyclohexane/ethylacetate 0-80%) to give 2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-1-[4-(3-nitro-phenyl)-piperazin-1-yl]- ethanone (1.24 g, 59%). 1 H-NMR (400 MHz, MeOD): delta =2.31 (s, 3H), 3.31-3.40 (m, 2H), 3.41-3.49 (m, 2H), 3.77-3.85 (m, 4H), 5.25 (s, 2H), 6.43 (s, 1 H), 7.38-7.42 (m, 1 H), 7.44-7.51 (m, 1 H), 7.69-7.72 (m, 1 H), 7.80-7.81 (s, 1 H). MS: m/z = 398 (M+1).

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Synthetic Route of 500011-84-7,Some common heterocyclic compound, 500011-84-7, name is 3-Bromo-1-(dimethylsulfamoyl)pyrazole, molecular formula is C5H8BrN3O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step B: Preparation of 3-bromopyrazole;To trifluoroacetic acid (70 mL) was slowly added 3-bromo-iV,N-dimethyl-lH- pyrazole-1 -sulfonamide (i.e. the bromopyrazole product of Step A) (57.04 g). The reaction mixture was stirred at room temperature for 30 minutes and then concentrated at reduced pressure. The residue was taken up in hexane, insoluble solids were filtered off, and the hexane was evaporated to afford the crude product as an oil. The crude product was further purified by chromatography on silica gel using ethyl acetate/dichloromethane (10:90) as eluent to afford an oil. The oil was taken up in dichloromethane, neutralized with aqueous sodium bicarbonate solution, extracted with methylene chloride (3x), dried over magnesium sulfate and concentrated to afford 25.9 g of the title product as a white solid, m.p. 61-64 C. 1H NuMR (CDCl3): delta 12.4 (br s,lH), 7.59 (d,lH), 6.37 (d,lH).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromo-1-(dimethylsulfamoyl)pyrazole, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 50877-42-4, name is 1-Benzyl-4-iodo-1H-pyrazole, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Benzyl-4-iodo-1H-pyrazole

Tri TBDMS derivative was obtained by treating 18 with TBDMSCl and imidazole in DMF. Lithiation with LTMP followed by quenching with tri n-butyltin chloride gave exclusively 2-stannyl derivative 20. Ammonolysis in 2-propanol gave 2-stannyladenosine 12. Stille coupling of 12 with 1 -benzyl-4-iodopyrazole in presence of Pd(PPl^ and CuI resulted in 21 (K. Kato et.al., J. Org. Chem. (1997), 62, 6833-6841). Deprotection of silyl groups on 2 upsilon and 5′ hydroxyls with 0.5 M ammonium fluoride in methanol gave 22 in good yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 129768-30-5 as follows. COA of Formula: C7H7F3N2O2

Reference Synthesis Example 55 (0639) 5-(Chloromethyl)-3-(trifluoromethyl)-1H-pyrazole (0640) To a tetrahydrofuran solution (4 mL) of ethyl 3-(trifluoromethyl)-1H-pyrazol-5-carboxylate (104 mg, 0.50 mmol), diisobutylaluminum hydride (1.75 mL, 1.75 mmol, toluene solution) was added at 0 C. and the resultant solution was stirred for 2 hours. To the reaction solution, saturated sodium sulfate aqueous solution was added and the resultant mixture was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. Subsequently, to a dichloromethane solution of the obtained residue (28 mg), thionyl chloride (39.4 mg, 0.33 mmol) was added and the resultant mixture was stirred at room temperature for 1 day. After completion of the reaction, the reaction solution was concentrated under reduced pressure to obtain a crude product of the title compound. The crude product was used in the next reaction as it was.

According to the analysis of related databases, 129768-30-5, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19968-17-3, name is 4-Bromo-3-(trifluoromethyl)-1H-pyrazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C4H2BrF3N2

4-Bromo-1-{[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}-5-(trifluoromethyl)-1H-pyrazole and 4-bromo-1-{[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}-3-(trifluoromethyl)-1H-pyrazole; A mixture of 4-bromo-3-trifluoromethyl-1H-pyrazole (400.0 mg, 1.861 mmol), toluene-4-sulfonic acid (S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester (799.2 mg, 2.791 mmol), K2CO3 (400.0 mg, 2.894 mmol) and DMF (6 mL, 80 mmol) was heated to 90 C. for 2 h. The material was extracted with EtOAc, washing with water (3¡Á). The organic layer was dry-loaded onto silica gel, and purified via column chromatography, eluting with 10-30% EtOAc/heptane. The fractions containing each pure product were concentrated in vacuo to afford the title compounds as clear oils. 3-Trifluoromethyl isomer: 1H NMR (400 MHz, CD3OD): delta=1.31 (s, 3H), 1.34 (s, 3H), 3.78 (dd, J=8.6, 5.8 Hz, 1H), 4.10 (dd, J=8.8, 6.6 Hz, 1H), 4.22-4.31 (m, 1H), 4.36 (dd, J=14.1, 4.0 Hz, 1H), 4.41-4.49 (m, 1H), 7.92 (s, 1H). MS (ES+): m/z=329.01/331.01 (100/100) [MH+]. HPLC: tR=1.59 min (polar-3 min, UPLC-ACQUITY). 5-Trifluoromethyl isomer: MS (ES+): m/z=329.01/331.01 (100/100) [MH+]. HPLC: tR=1.62 min (polar-3 min, UPLC-ACQUITY).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Some common heterocyclic compound, 345637-71-0, name is 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, molecular formula is C7H7F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 345637-71-0

1,1-Dimethylethyl 4-[4-[[methyl[(l/?)-l-phenylpropyl]amino]carbonyl]-2-oxazolyl]-l- piperidinecarboxylate (i.e. the product of Example 7, Step E) (209 mg, 0.49 mmol) was dissolved in 3 mL of a mixture of dichloromethane and methanol (1:1), and 1.23 mL (4.9 mmol) of 1 N HCl in dioxane was added. The reaction mixture was stirred at room temperature for 3 h. The solvents were evaporated under reduced pressure, and the residue was dissolved in 5 mL methanol and concentrated under reduced pressure (this procedure was repeated 3 times) to give the amine hydrochloride. To a solution of 5-methyl-3- (trifluoromethyl)-lH-pyrazole-l-acetic acid (89.5 mg, 0.43 mmol) and triethylamine (87 mg, 0.86 mmol) in 2 mL of dry acetonitrile was added a suspension of O-benzotriazol-1-yl- N,N,N’,//’-tetramethyluronium hexafluorophosphate (178.25 mg. 0.47 mmol) in 2 mL acetonitrile and then a mixture of 140 mg (0.43 mmol) of the amine hydrochloride in 2 mL acetonitrile. The resulting mixture was stirred at room temperature for 3 h and concentrated under reduced pressure. The residue was purified by silica gel chromatography using 25-75 % of ethyl acetate in hexanes to give 84 mg of the title product, a compound of the present invention, as an oil.1H NMR (CDCl3) delta 0.90-1.04 (m, 3H), 1.71-1.89 (m, 2H), 1.90-2.19 (m, 4H), 2.28-2.35 (m, 3H), 2.72 (s, 2H), 3.00-3.2 (m, 3H), 3.30-3.36 (t, IH), 3.87-4.35 (m, 2H), 4.98 (s, 2H), 5.92- 6.12 (m, IH), 6.3 (s, IH), 7.25-7.4 (m, 5H), 8.08-8.15 (br s, IH).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 345637-71-0, its application will become more common.