Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 50877-42-4, name is 1-Benzyl-4-iodo-1H-pyrazole, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Benzyl-4-iodo-1H-pyrazole
Tri TBDMS derivative was obtained by treating 18 with TBDMSCl and imidazole in DMF. Lithiation with LTMP followed by quenching with tri n-butyltin chloride gave exclusively 2-stannyl derivative 20. Ammonolysis in 2-propanol gave 2-stannyladenosine 12. Stille coupling of 12 with 1 -benzyl-4-iodopyrazole in presence of Pd(PPl^ and CuI resulted in 21 (K. Kato et.al., J. Org. Chem. (1997), 62, 6833-6841). Deprotection of silyl groups on 2 upsilon and 5′ hydroxyls with 0.5 M ammonium fluoride in methanol gave 22 in good yield.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.