Category: 50877-42-4

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 50877-42-4, name is 1-Benzyl-4-iodo-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 50877-42-4

b) 1 -Benzyl- 1 H -pyrazole-4 -carbaldehyde (A 148) 1-Benzyl-4-iodo-1 H-pyrazole A147 (859 mg, 3.02 mmol) in THF (5 mL) was cooled to 0 C under nitrogen before a 2.0 M solution of isopropylmagnesium chloride in THF (1.66 mL, 3.33 mmol) was added. After 1 hour, DMF (0.5 mL) was added. The mixture was stirred for 30 minutes at 0 C then a further 30 minutes at room temperature. The mixture was quenched with a saturated aqueous solution of ammonium chloride (10 mL), diluted with water (20 mL) and extracted with CHCI3 (3 chi 25 mL). The pooled organics were washed with brine (50 mL), dried with sodium sulfate and concentrated in vacuo. The crude material was purified by column chromatography (12 g Si02 cartridge, 0-50% EtOAc in hexanes) to give the title compound as a colourless oil (170 mg, 30%). H NMR (400 MHz, CDCI3) delta 9.83 (s, 1 H), 8.00 (s, 1 H), 7.88 (s, 1 H), 7.42-7.33 (m, 3H), 7.29-7.25 (m, 2H), 5.33 (s, 2H). LCMS-B: rt 3.10 min, m/z (positive ion) 187.1 [M+H]+.

According to the analysis of related databases, 50877-42-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CANCER THERAPEUTICS CRC PTY LTD; STUPPLE, Paul Anthony; WALKER, Scott Raymond; PINSON, Jo-Anne; LAGIAKOS, Helen Rachel; LUNNISS, Gillian Elizabeth; HOLMES, Ian Peter; STUPPLE, Alexandra Elizabeth; BERGMAN, Ylva Elisabet; FOITZIK, Richard Charles; KERSTEN, Wilhelmus Johannes Antonius; CAMERINO, Michelle Ang; WO2014/128465; (2014); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 50877-42-4, name is 1-Benzyl-4-iodo-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1-Benzyl-4-iodo-1H-pyrazole

General procedure: A mixture of K2CO3 (0.552 g, 4.0 mmol), Ph3P (5.3 mg,0.02 mmol) and 10% palladium on charcoal (10.6 mg, 0.01 mmol) in EtOH(10 ml) was stirred gently for 30 min, then the hetaryl halide (1.0 mmol) andterminal acetylene (1.2 mmol) were added. The mixture was stirred gently atreflux for 48 h. The resulting precipitate was filtered through a pad of silica geland the EtOH was evaporated. Pure product was isolated by columnchromatography on silica gel using petroleum ether/EtOAc as eluent

The synthetic route of 1-Benzyl-4-iodo-1H-pyrazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Arsenyan, Pavel; Rubina, Kira; Vasiljeva, Jelena; Belyakov, Sergey; Tetrahedron Letters; vol. 54; 48; (2013); p. 6524 – 6528;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 50877-42-4, name is 1-Benzyl-4-iodo-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 50877-42-4, Safety of 1-Benzyl-4-iodo-1H-pyrazole

General procedure: To a solution of 4-iodo-1-methyl-1H-pyrazole (3.0 g, 14.4 mmol, 1.0 eq.), 4,5-Bis(diphenylphosphino)-9,9-dimethylxanthene (xantphos) (835 mg, 1.4 mmol, 0.1 eq.) and palladium(II) acetate (415 mg, 0.7 mmol, 0.05 eq.) in dioxane (72.1 ml, 0.2 M) was added N,N’-diisopropylethylamine (5.0 mL, 28.9 mmol, 2.0 eq.) and benzylmercaptan (2.0 ml, 17.3 mmol, 1.2 eq.). The reaction mixture was stirred at 100 C for 18 h. The reaction mixture was diluted with ethyl acetate (300 mL) and water (150 mL). The aqueous layer was extracted with ethyl acetate (150 mL). The combined organic layers were dried (Na2SO4) and concentrated under reduced pressure. The residue was purified by column chromatography.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Benzyl-4-iodo-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Vernier, William F.; Gomez, Laurent; Tetrahedron Letters; vol. 58; 49; (2017); p. 4587 – 4590;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 50877-42-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 50877-42-4, name is 1-Benzyl-4-iodo-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 1-benzyl-4-iodo-1H-pyrazole (1.05 g, 3.70 mmol) , bis (pinacolato) diboron (1.00 g, 3.94 mmol) , potassium acetate (1.00 g, 9.88 mmol) and Pd (dppf) Cl2(130 mg, 0.18 mmol) in DMSO (20 mL) was stirred at 80 under N2for 7 h. The reaction mixture was cooled to rt and quenched with water (50 mL) . The resulting mixture was extracted with EtOAc (50 mL × 3) . The combined organic layers were washed with saturated aqueous NaCl (50 mL × 2) , dried over anhydrous Na2SO4and concentrated in vacuo. The residue was purified by silica gel column chromatography eluted with PE/EtOAc (v/v) 5/1 to give a light yellow oily product (200 mg, 19.0) .[1088]MS (ESI, pos. ion) m/z: 282.3 [M+1]+ and[1089]1H NMR (600 MHz, CDCl3) : delta (ppm) 7.84 (s, 1H) , 7.69 (s, 1H) , 7.34 (m, 3H) , 7.25 (m, 2H) , 5.32 (s, 2H) , 1.32 (s, 12H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Benzyl-4-iodo-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; LIU, Bing; ZHANG, Yingjun; CHENG, Changchung; HUANG, Jiuzhong; BAI, Shun; REN, Xingye; LI, Zhi; ZHOU, Youbai; (368 pag.)WO2016/615; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 50877-42-4, name is 1-Benzyl-4-iodo-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C10H9IN2

General procedure: To iodopyrazole (1 mmol) dissolved in THF (10 mL), Fuajasite (250 mg) was added. Nitric acid (d 1.52 g/cm3, 10 mL) was added slowly and the mixture was stirred at room temperature for required time. The catalyst was recovered by filtration and the filtrate was extracted repeatedly with dichloromethane. The solvent was removed under vacuum to obtain nitropyrazole.

The synthetic route of 1-Benzyl-4-iodo-1H-pyrazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ravi; Tewari, Surya P.; Catalysis Communications; vol. 42; (2013); p. 35 – 39;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 50877-42-4,Some common heterocyclic compound, 50877-42-4, name is 1-Benzyl-4-iodo-1H-pyrazole, molecular formula is C10H9IN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 4-[7-(1-ethylpropyl)-5-(4-fluorophenyl)furo[3,2-b]pyridine-2-carbonyl]- 3,3-dimethyl-piperazin-2-one (70 mg, 0.160 mmol) in DMF (1.750 mL) were added 1- benzyl-4-iodo-pyrazole (68.18 mg, 0.240 mmol), CuI (15.23 mg, 0.080 mmol) and K3PO4 (67.93 mg, 0.320 mmol). The mixture was degassed for 10 min, then to it was added N,N’-dimethylethane-1,2-diamine (14 mg, 16.91 muL, 0.159 mmol). The mixture was allowed to stir overnight at 100C. The suspension was cooled down, water was added along with EtOAc. The phases were separated to afford a crude mixture of 1-(1- benzylpyrazol-4-yl)-4-[7-(1-ethylpropyl)-5-(4-fluorophenyl)furo[3,2-b]pyridine-2- carbonyl]-3,3-dimethyl-piperazin-2-one (95.0 mg, 100.0%)

The synthetic route of 50877-42-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; SAYEGH, Camil Elie; STURINO, Claudio; FOURNIER, Pierre-Andre; LACOSTE, Jean-Eric; DIETRICH, Evelyne; MARTEL, Julien; VALLEE, Frederic; (494 pag.)WO2016/154075; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 50877-42-4, name is 1-Benzyl-4-iodo-1H-pyrazole, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Benzyl-4-iodo-1H-pyrazole

Tri TBDMS derivative was obtained by treating 18 with TBDMSCl and imidazole in DMF. Lithiation with LTMP followed by quenching with tri n-butyltin chloride gave exclusively 2-stannyl derivative 20. Ammonolysis in 2-propanol gave 2-stannyladenosine 12. Stille coupling of 12 with 1 -benzyl-4-iodopyrazole in presence of Pd(PPl^ and CuI resulted in 21 (K. Kato et.al., J. Org. Chem. (1997), 62, 6833-6841). Deprotection of silyl groups on 2 upsilon and 5′ hydroxyls with 0.5 M ammonium fluoride in methanol gave 22 in good yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.