Tag: M.W:200-300

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 70951-85-8, name is 4-Bromo-1-(tert-butyl)-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., category: pyrazoles-derivatives

Isopropyl magnesium chloride lithium chloride complex (1.3 M in THF, 28.4 mL, 37 mmol) was charged to a solution of 4-bromo-1-(tert-butyl)-1H-pyrazole (5.0 g, 25 mmol) in anhydrous THF (25 mL) under argon at ambient temperature. Anhydrous dioxane (3.3 g, 37 mmol) was charged to the reaction, and the reaction was agitated at 45 00 for 4 h. The resulting mixture was cooled to ambient temperature and charged to an anhydrous solution of acetic anhydride (7.5 g, 73 mmol) in THF (25 mL) at -20 00 The resulting mixture was warmed to ambient temperature and concentrated to a residue. The mixture was dissolved in methyl t-butyl ether (50 mL) and washed with water (25 mL). The organic portion was concentrated to provide crude 1-(1-(tert-butyl)-1H-pyrazol-4-yl)ethan-1-one as an oil (7.6 g, 36 wt%) and 67% yield. Crystallization in a mixture of methyl t-butyl ether and heptane provided analytically pure material 1 -(1 -(tert-Butyl)-1 H-pyrazol-4-yl)ethan-1 -one. NMR (500 MHz, ODd3) = 7.96 (s, 1 H), 7.86 (s, 1 H), 2.37 (s, 3H), 1.55 (s, 9H).

According to the analysis of related databases, 70951-85-8, the application of this compound in the production field has become more and more popular.

Electric Literature of 345637-71-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 345637-71-0, name is 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

4-[4-(5-{2-[(Methylsulphonyl)ammonio]phenyl}-4,5-dihydro-1,2-oxazol-3-yl)-1,3-thiazol-2-yl]piperidinium dichloride (201 mg), [5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid (104 mg) and triethylamine (51 mg) are dissolved in dichloromethane (10 ml) and the mixture is stirred for 10 min. The mixture is stirred for a further 10 min, before bromotris(pyrrolidino)phosphonium hexafluorophosphate (254 mg) is added. The reaction mixture is stirred at room temperature for 2 hours. After removal of the solvent under reduced pressure, the residue is purified by chromatography. This gives N-(2-{3-[2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-O-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}phenyl)methanesulphonamide (107 mg).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, other downstream synthetic routes, hurry up and to see.

Application of 5334-28-1,Some common heterocyclic compound, 5334-28-1, name is 5-Amino-1-(4-bromophenyl)-1H-pyrazole-4-carbonitrile, molecular formula is C10H7BrN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1.4: 5-Amino-1-(4-bromo-phenyl)-1H-pyrazole-4-carboxylic acid amide5-Amino-1-(4-bromo-phenyl)-1 H-pyrazole-4-carbonitrile (18.3 g, 69.8 mmol) is slowly added to 93 ml concentrated sulfuric acid (1680 mmol) to keep the temperature between 10-15 C. After the complete addition of the starting material, the reaction mixture is stirred for one hour. Afterwards, the mixture is poured on ice/water and the pH is adjusted to pH 8. The formed precipitate is isolated by filtration and is dried at the high vacuum pump, yielding the title compound. HPLC: tR = 7.91 min; MS-ES+: (M+H)+ = 282

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-1-(4-bromophenyl)-1H-pyrazole-4-carbonitrile, its application will become more common.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 34091-51-5, name is 5-Iodo-1-methyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Product Details of 34091-51-5

A solution of 5-iodo-l -methyl-lH-pyrazole (1.90 g,9.14 mmol),2-(4,4-difluorocyclohex-l-en-l-yl)-4,4,5,5-tet-ramethyl-l,3,2-dioxaborolane(1.00 g, 4.10 mmol), tetrakis (triphenylphosphine)palladium(O) (240 mg, 0.208mmol), and cesium carbonate (2.70 g, 8.29 mmol) in 1,4-dioxane (10 mL) andwater (5.0 mL) was stirred at 90 C. for 4 hours. After allowing to cool, thereaction solution was subjected to extraction with ethyl acetate (50 mL), andthe organic layer was dried over anhydrous sodium sulfate. The organic layer was concentrated under reduced pressure, and the residue was purified with column chromatography (hexane/ethyl acetate=9:l) to yield the title compound(767 mg, 94%) as a colorless oil.

The synthetic route of 34091-51-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Daichi Sankyo Corporation; Takahashi, Sakiko; Domon, Yuki; Kitano, Yutaka; Sinojika, Tsuyoshi; (102 pag.)KR2015/126620; (2015); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 938066-17-2, name is 4-Iodo-1-(tetrahydropyran-2-yl)-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Safety of 4-Iodo-1-(tetrahydropyran-2-yl)-1H-pyrazole

lodopyrazole (153 g, 550 mmol, 1.1 equiv.) was dissolved in THF (2 L) under N2 and the solution was cooled in an ice-water bath. i-PrMgC1 (2 M in THF, 300 mL, 600 mmol,1.2 equiv.) was added dropwise with vigorous stirring. After 60 minutes, solid benzoxazinonesubstrate was added, and the ice bath was removed. After 45 minutes, 10% aqueous NaOH (720mL, 2 mol, 4 equiv.) was added, and the mixture was heated to 65 C. After five hours, thereaction mixture was cooled to room temperature, quenched with 10% aqueous HC1 (690 mL, 2 mol, 4 equiv.), and extracted with EtOAc. The combined organic extracts were dried and concentrated to afford a viscous yellow/orange oil that was used without further purification.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 938066-17-2.

Reference:
Patent; ARCUS BIOSCIENCES, INC.; LELETI, Manmohan, Reddy; MILES, Dillon, Harding; POWERS, Jay, Patrick; ROSEN, Brandon, Reid; SHARIF, Ehesan, Ul; THOMAS-TRAN, Rhiannon; (154 pag.)WO2018/204661; (2018); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 1202993-11-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1202993-11-0 as follows.

3.2 g of 5-chloro-3-(difluoromethyl)-1 -methyl-1 H-pyrazole-4-carboxylic acid and 44.3 mL of thionyl chloride are refluxed for 5 hours. After cooling down, the reaction mixture is evaporated under vacuum to yield 3.5 g of 5-chloro-3-(difluoromethyl)-1 -methyl-1 H-pyrazole-4-carbonyl chloride as a yellow oil. H NMR (400 MHz, CHCI3-c/6) delta ppm : 3.97 (s, 3H); 7.00 (t, J = 52.01 Hz, 1 H); IR (TQ) : 1759 and 1725 cm”1 (C=0).

According to the analysis of related databases, 1202993-11-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER CROPSCIENCE AG; BENTING, Juergen; CRISTAU, Pierre; DAHMEN, Peter; DESBORDES, Philippe; GARY, Stephanie; SCHMIDT, Jan-Peter; WACHENDORFF-NEUMANN, Ulrike; WO2012/59497; (2012); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 938066-17-2, name is 4-Iodo-1-(tetrahydropyran-2-yl)-1H-pyrazole, A new synthetic method of this compound is introduced below., COA of Formula: C8H11IN2O

(2) 27.8 g of the intermediate 4-bromo-1- (tetrahydro-2H-pyran-2-yl) -1H-pyrazole obtained in (1) was dissolved in 200 ml of THF,Cool to minus 75 degrees,48 ml (0.12 mol) of n-butyl lithium solution with a concentration of 2.5 mol / L was added dropwise,Maintain the temperature around minus 75 degrees,After dropping, keep warm for half an hour,Subsequently, 8.8 g (0.12 mol) of N, N-dimethylformamide is added at this temperature, and the reaction formula of step (2) is as follows:After the reaction is completed, naturally warm to room temperature,Add dilute hydrochloric acid to quench until the system pH is less than 1, stir at room temperature for 3-4 hours, neutralize with sodium bicarbonate, and extract with ethyl acetate.After drying and concentration, it was purified by silica gel short column adsorption to obtain the target product 4-formylpyrazole 7.2 g.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Changsha Luxing Biological Technology Co., Ltd.; Tan Yongjun; Yang Bing; Zhu Zhiping; Zhang Jianhua; (10 pag.)CN110734401; (2020); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: 37687-24-4

A mixture of diethyl 1H-pyrazole-3,5-dicarboxylate (5.20 g, 24.5 mmol), 2-chloro-1-(3-chloro-4-methylphenyl)ethan-1-one (4.98 g, 24.5 mmol), potassium carbonate (3.73 g, 27.0 mmol) and water (3 drops) in acetone (100 ml) was stirred at RT overnight. The solids were then filtered off, and the filtrate was concentrated under reduced pressure. The residue was partitioned between dichloromethane and water. The layers were separated, and the organic layer was washed with water and brine, dried over sodium sulfate and filtered. The filtrate was concentrated under re- duced pressure to afford the crude title compound which was directly used in the next step with- out further purification. Yield: 7.99 g (83% of theory, 97% purity). LC/MS [Method 34]: Rt = 1.39 min; MS (ESIpos): m/z = 379/381 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51516-67-7, name is 5-Amino-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below., COA of Formula: C10H7ClN4

General procedure: Equimolar portionsof the intermediate compounds 1 (1 mmol) and the intermediatecompounds 3 (1 mmol) were dissolved in approximately 8 mL ofethanol. The reaction solution was allowed to stir at 80 8C for 2 huntil the reaction was complete. The reaction was monitored byTLC. Mostly, a precipitate formed and was then collected by suctionfiltration.

The synthetic route of 51516-67-7 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1280210-79-8, name: tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate

To a suspension ofNaH (0.30 g, 7.5 mmol) in dry THF (5 mL) under nitrogen atmosphere at 0 C was added a solution of 4 (0.78 g, 3.7 mmol) in dry THF (30 mL). Thereaction mixture was allowed to come to room temperature and continued the stirring for 2hours. Reaction mixture was again cooled to 0 C. A solution of3 (2.0 g, 7.4 mmol) in THF (25mL) was added to the reaction mixture and continued the stirring for another 1 hour. Thereaction mixture was quenched with water (100 mL) and extracted with EtOAc (3 x 200 mL). Combined organics were dried over Na2S04, filtered, concentrated under vacuum and purifiedby silica gel chromatography afforded 5 as an off-white solid.251H NMR (400 MHz, CDCh): o 7.84- 7.88 (m, 1H), 7.78 (t, J = 8.27 Hz, 2H), 7.23- 7.30 (m,2H), 4.39 – 4.49 (m, 4H), 3.53 ( d, J = 2.40 Hz, 3H), 2.42 (s, 3H), 1.53 (s, 9H).; MolecularFormula: C1sHz4N40sSz; LCMS purity: 98.18%; Expected: 440.1; Observed: 341.0 (M-99).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, other downstream synthetic routes, hurry up and to see.