Adding a certain compound to certain chemical reactions, such as: 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1280210-79-8, name: tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate
To a suspension ofNaH (0.30 g, 7.5 mmol) in dry THF (5 mL) under nitrogen atmosphere at 0 C was added a solution of 4 (0.78 g, 3.7 mmol) in dry THF (30 mL). Thereaction mixture was allowed to come to room temperature and continued the stirring for 2hours. Reaction mixture was again cooled to 0 C. A solution of3 (2.0 g, 7.4 mmol) in THF (25mL) was added to the reaction mixture and continued the stirring for another 1 hour. Thereaction mixture was quenched with water (100 mL) and extracted with EtOAc (3 x 200 mL). Combined organics were dried over Na2S04, filtered, concentrated under vacuum and purifiedby silica gel chromatography afforded 5 as an off-white solid.251H NMR (400 MHz, CDCh): o 7.84- 7.88 (m, 1H), 7.78 (t, J = 8.27 Hz, 2H), 7.23- 7.30 (m,2H), 4.39 – 4.49 (m, 4H), 3.53 ( d, J = 2.40 Hz, 3H), 2.42 (s, 3H), 1.53 (s, 9H).; MolecularFormula: C1sHz4N40sSz; LCMS purity: 98.18%; Expected: 440.1; Observed: 341.0 (M-99).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, other downstream synthetic routes, hurry up and to see.