Tag: M.W:100-200

Application of 5334-40-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.

Into a 50 mL round bottom flask containing a solution of 4-nitro-7H-pyrrazole-3-carboxalic acid (5.0 g, 32 mmol) in methanol (50 mL) was added concentrated sulfuric acid (1 mL) at 0 C. The resulting slurry was stirred at reflux temperature overnight. The solvents were evaporated under reduced pressure and the residual mass was dissolved in ethyl acetate and washed with water and brine solution. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated to yield methyl 4-nitro-7H-pyrazole-3-carboxylate as a solid which was taken to next step without further purification. 1Eta NMR (CD3OD 300 MHz): delta 8.59 (s, 1H), 3.93 (s, 3H). MS calc’d [M-H]+ 170.0, found 170.1.

The chemical industry reduces the impact on the environment during synthesis 4-Nitro-1H-pyrazole-3-carboxylic acid. I believe this compound will play a more active role in future production and life.

Adding a certain compound to certain chemical reactions, such as: 2075-45-8, name is 4-Bromo-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2075-45-8, SDS of cas: 2075-45-8

4-bromopyrazole (22.0 g) was dissolved in DMF (75 mL)Add K2CO3 (51.8 g, 2.5 eq) andDimethylaminoethane hydrochloride,And then reacted at room temperature for two days.Was added to EA (500 mL) and then washed successively with water and saturated brine, dried over Na2SO4 and subjected to column chromatography (1-20% MeOH / DCM) to give 36 (21.85 g, 66.5%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1H-pyrazole, and friends who are interested can also refer to it.

Related Products of 1190380-49-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1190380-49-4 name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a 100 ml flask were added methyl 2,4-dichloro-6-methylpyrimidine-5-carboxylate (309 mg, 1.4 mmol), 1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-amine (234 mg, 1.4 mmol), 10 ml of acetonitrile and DIPEA (0.54 g, 4.18 mmol). The reaction mixture was stirred at 40 C. for 1 h, acetonitrile was evaporated under reduced pressure and then 30 ml of EtOAc was added. The mixture was washed with 60 ml of water and 30 ml of brine. The organic phase was dired and concentrated to give 405 mg of intermediate 7a as a grey solid. MS m/z (ESI): 352.1[M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 158001-28-6, name is 5-Amino-1-(tert-butyl)-1H-pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below., Formula: C8H12N4

To 5-amino-1-tert-butyl-1H-pyrazole-4-cyano (1.1g, 6.75mmol) was added formamide (15mL), heated to reflux for 6 hours to obtain a reaction solution, the reaction solution was treated with ethyl acetate The ester (3¡Á30mL) was extracted, and the resulting organic layer was dried over anhydrous magnesium sulfate. After filtration, the solvent was evaporated under reduced pressure to obtain a brown solid (0.97g, 5.1mmol) (yield 76%).

The synthetic route of 158001-28-6 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 180207-57-2, name is 2-(1H-Pyrazol-4-yl)ethanol, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 180207-57-2, Quality Control of 2-(1H-Pyrazol-4-yl)ethanol

A solution of 2-(1H-pyrazol-4-yl)ethan-1-ol (3.00 g, 26.75 mmol, 1.00 equiv), SEM-Cl (7.00 mL, 43.18 mmol, 1.61 equiv) and Cs2CO3 (13.00 g, 39.89 mmol, 1.49 equiv) in N,N-dimethylformamide (20 mL) was stirred for 3 h at room temperature. When LCMS indicated most of starting material was converted into the desired product, the resulting solution was concentrated and diluted with 150 mL of dichloromethane, washed with 3×50 mL of brine, dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was purified by a silica gel column eluting with DCM/MeOH (10:1) to afford 2.6 g of the title compound as yellow oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Related Products of 3994-50-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3994-50-1 as follows.

General procedure: To a 8 mL glass vial equipped with a magnetic stirbar were sequentially added K2CO3 (207 mg, 1.5 mmol), the nitroazole substrate (0.50 mmol), aryl halide (0.50 mmol oras indicated), toluene (0.50 M or 1.0 M), Pd(OAc)2 (5.60mg, 0.025 mmol) and [PCy3H]BF4 (18.4 mg, 0.050 mmol).The reaction mixture was purged with nitrogen through aTeflon-lined cap. Then the cap was replaced with a newTeflon-lined solid cap. The reaction vial was moved to a preheatedreaction block. After stirring for 18 h at the indicatedtemperature, the reaction mixture was cooled to 25 C and concentrated. The residue was purified by flash column chromatography to provide the desired arylated product.

According to the analysis of related databases, 3994-50-1, the application of this compound in the production field has become more and more popular.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 35691-93-1, name is Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C8H12N2O2

General procedure: 4.3.1. Ethyl 5-amino-2-methylpyrazolo[1,5-a]quinoline-3-carboxylate (7a). Condition C: A mixture of 2-fluorobenzonitrile6a (121 mg, 1.00 mmol), 1H-pyrazole 4 (202 mg, 1.20 mmol) andCs2CO3 (980 mg, 3.00 mmol) in DMF (5.0 mL) was stirred at 120 Cfor 16 h. After monitoring the end of the reaction on TLC, themixture was cooled to room temperature and diluted with water.The resulting mixture was extracted with ethyl acetate twice. Thecombined organic layers werewashed with water twice, dried overMgSO4 and the solvent was removed in vacuo to afford a residue.The residue was purified by flash column chromatography(hexane:EtOAc1:1) on silica gel to afford 7a (124 mg, 46% yield).Condition D: The reaction was carried out in DMSO instead of DMFunder the same conditions as that of condition C to afford 7a (175 mg, 65% yield).

The synthetic route of 35691-93-1 has been constantly updated, and we look forward to future research findings.

Electric Literature of 3994-50-1,Some common heterocyclic compound, 3994-50-1, name is 1-Methyl-4-nitro-1H-pyrazole, molecular formula is C4H5N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 317 3-amino-6-bromo-N-(1-methyl-1H-pyrazol-4-yl)picolinamide 317 1-Methyl-4-nitro-1H-pyrazole (1.62 g, 12.7 mmol) was dissolved in methanol (250 mL) and hydrogenated on H-Cube at 60 bar hydrogen pressure and 70 C. to give 1-methyl-1H-pyrazol-4-amine (1.23 g, 99%). To a 100 mL round bottom flask containing 1-methyl-1H-pyrazol-4-amine (700 mg, 7.0 mmol), 3-amino-6-bromopicolinic acid (1.86 g, 8.5 mmol) and PyBop (4.12 g, 8.0 mmol) was added methylene chloride (30 mL) and diisopropylethylamine (3.8 mL, 21.6 mmol). The reaction mixture was stirred for 24 hr at room temperature and the reaction was monitored by LCMS. Upon completion of the reaction, the solvent was distilled off and the crude material was purified via flash chromatography, heptane/ethyl acetate 0% to 100% to afford a yellow solid. A fraction of it was purified via reverse phase HPLC to afford 317. 1H NMR (400 MHz, DMSO) delta 10.25 (s, 1H), 8.03 (s, 1H), 7.70 (s, 1H), 7.43 (d, J=8.7 Hz, 1H), 7.19 (d, J=8.7 Hz, 1H), 7.02 (br, 2H), 3.81 (s, 3H). MS (ESI) m/z: 296.0/298.0 [M+H+].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-4-nitro-1H-pyrazole, its application will become more common.

Synthetic Route of 176969-34-9, These common heterocyclic compound, 176969-34-9, name is 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Will be 18 grams (0.1 mole)3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acidAdd 30 ml of toluene10 drops of DMF, 30 g (0.25 mol) of thionyl chloride was added dropwise at room temperature.Then, the temperature was refluxed for 5 hours.Remove the solvent by rotary evaporator to get reddish brown3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carbonyl chloride.

The synthetic route of 176969-34-9 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 3524-32-1, name is 5-Amino-1,3-dimethylpyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 3524-32-1

General procedure: A solution of equimolar amounts (4.5 mmol) of 1,3-dimethyl-1H-pyrazol-5-amine 3 [18] and substituted phenylisocyanates 4a-g in THF (12 mL) was stirred at room temperature for 24 h. The solid residue was filtered, washed with 1 mL of ethyl acetate, and then crystallized from a suitable solvent.

The synthetic route of 5-Amino-1,3-dimethylpyrazole has been constantly updated, and we look forward to future research findings.