Adding a certain compound to certain chemical reactions, such as: 2075-45-8, name is 4-Bromo-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2075-45-8, SDS of cas: 2075-45-8
4-bromopyrazole (22.0 g) was dissolved in DMF (75 mL)Add K2CO3 (51.8 g, 2.5 eq) andDimethylaminoethane hydrochloride,And then reacted at room temperature for two days.Was added to EA (500 mL) and then washed successively with water and saturated brine, dried over Na2SO4 and subjected to column chromatography (1-20% MeOH / DCM) to give 36 (21.85 g, 66.5%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1H-pyrazole, and friends who are interested can also refer to it.