Tag: M.W:100-200

Application of 37622-90-5,Some common heterocyclic compound, 37622-90-5, name is Ethyl 4-pyrazolecarboxylate, molecular formula is C6H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The solution of ethyl 1H-pyrazole-4-carboxylate (2.5 g, 17.9 mmol), and iodomethane (3.1 g, 21.5 mmol) in DIVIF (10 mL) was added K2C03 (5.0 g, 35.8 mmol) and then the reaction mixture was stirred at room temperature for 16 hrs. Water (50 mL) was added to the mixture and then extracted by EA (50 mL x2). The organic layer was washed with brine (40 mL), dried over Na2SO4, and concentrated under reduced pressure. The residue was purified by silica gel column (PE/EA = 8/1) to give the ethyl 1-methyl-1H-pyrazole-4-carboxylate (214 mg, yield: 85%) as a colorless oil. ?H NIVIR (300 IVIHz, DMSO-d6): oe = 8.28 (s, 1H), 7.82 (s, 1H), 4.26 (q, J= 6.9 Hz, 2H), 3.87 (s, 3H), 1.25 (t, J= 6.9 Hz, 3H). MS: m/z 155.3 (M+H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 4-pyrazolecarboxylate, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 288148-34-5

General procedure: 1mL of a solution containing arylsulfonyl chloride or arylacyl chloride or arylisocyanates ([Diversity reagent 13{1-8},13{9-10} or 13{11-12}, 0.40 mmol, 5 equiv) in CH2Cl2was added to the resin followed by addition of DIEA (0.88 mmol, 11 eq). Thereactors were shaken for 2 h at room temperature. The resin was drained andwashed with DMF (3 x 5 mL), MeOH (1 x 5 mL), and CH2Cl2(3 x 5 mL), and dried under low vacuum. The procedure described abovewas repeated.

According to the analysis of related databases, 288148-34-5, the application of this compound in the production field has become more and more popular.

35691-93-1, name is Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 35691-93-1

4.2.1 Ethyl 2,5-dimethylpyrazolo[1,5-a]quinoline-3-carboxylate (5a) Condition A: A mixture of 2-fluoroacetophenone 3a (138 mg, 1.00 mmol), 1H-pyrazole 2a (202 mg, 1.20 mmol) and K2CO3 (420 mg, 3.00 mmol) in DMF (5.0 mL) was stirred at 120 C for 16 h. After monitoring the end of the reaction on TLC, the mixture was cooled to room temperature and diluted with water. The resulting mixture was extracted with ethyl acetate twice. The combined organic layers were washed with water twice, dried over MgSO4 and the solvent was removed in vacuo to afford a residue. The residue was purified by flash column chromatography (hexane:EtOAc=5:1) on silica gel to afford 5a (92.0 mg, 34% yield). Condition B: The reaction was carried out with Cs2CO3 instead of K2CO3 under the same conditions as that of Condition A to afford 5a (210 mg, 78% yield).

The synthetic route of 35691-93-1 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 25016-20-0

Acid R2b (8.2 mg, 0.065 mmol, 1.3 equiv) is dissolved in DMF (0.5 mL), then TEA (35 muIota_, 0.25 mmol, 5.0 equiv) is added followed by TBTU (19 mg, 0.060 mmol, 1.2 equiv). The solution is stirred for 15 mins, after which the amine hydrochloride Da (37 mg, 0.050 mmol) is added in DMF (0.5 mL). The solution is stirred at RT for 16 h. Water (2 mL) is added and the organic layer is extracted with EtOAc (3 x5 mL). The solvent is then evaporated and purified on prep HPLC (MeCN:H20, 0.1% TFA). The pure fractions are combined, concentrated, frozen and lyophilized to provide compound 1003. FIA M.S.(electrospray): 806.4 (M+H)+ Retention time (min) = 5.5 min1H NMR (400 MHz,DMSO-d6): delta 11.03 (s, 1H) , 8.81 (s, 1H), 7.83 (d, 1H, J = 8.8 Hz), 7.78-7.74 (m, 2H), 7.08 (d, 1H, J = 9.3 Hz), 6.60 (d, 1H, J = 2.3 Hz), 6.37 (s, 1H), 5.67-5.58 (m, 1H), 5.53-5.42 (m, 2H), 5.14 (dd, 1H, J = 9.5, 9.2 Hz), 4.64-4.57 (m, 1H), 4.51 (d, 1H, J= 11.6 Hz), 4.38 (dd, 1H, J= 9.4, 7.0 Hz), 4.01 (dd, 1H, J = 11.8, 3.5 Hz), 3.89 (s, 3H), 3.88 (s, 3H), 2.96-2.88 (m, 1H), 2.65-2.57 (m, 1H), 2.44 (s, 3H), 2.40-2.28 (m, 2H), 2.00-1.89 (m, 1H), 1.88-1.77 (m, 1H), 1.62-1.51 (m, 3H), 1.50-1.33 (m, 11H), 1.31-1.19 (m, 2H), 1.14-0.98 (m, 4H).

The synthetic route of 25016-20-0 has been constantly updated, and we look forward to future research findings.

Reference of 25016-11-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25016-11-9, name is 1-Methyl-1H-pyrazole-4-carbaldehyde belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step 1 : methyl 14-cvclohexyl-6-f(l -methyl- 1 H-pyrazol-4-yl )methyl]-5.6.7, 8-tetrahvdroindolo[2, 1 – a] [2,5 Jbenzodiazocine-] 1 -carboxylate; To a solution of methyl 14-cyclohexyl-5,6,7,8-tetrahydroindolo[2,l-a][2,5]-benzodiazocine-l l- carboxylate (prepared as described in Example 48, Step 3) in MeOH (0.06 M), 1 -methyl- lH-pyrazole-4- carbaldehyde (3 eq) was added and the pH adjusted to pH 4 with acetic acid. The solution was stirred at RT for 30 mins before addition of NaBH3CN (1.5 eq). The reaction was stirred at RT for 16 h. The reaction was quenched with saturated aqueous NaHCO3 and extracted with EtOAc (x2). The combined organics were washed with brine, dried (Na2SO1O, filtered and concentrated in vacuo to give the title compound as a viscous oil (quantitative); MS (ES+) m/z 483 (M+H)+

The synthetic route of 1-Methyl-1H-pyrazole-4-carbaldehyde has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 16209-00-0, name is 4-(1H-Pyrazol-1-yl)benzoic acid, molecular formula is C10H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 16209-00-0

To a suspension of 4-(pyrazol-1-yl)benzoic acid (1.56 g) in dichloromethane (25 ml) was added oxalyl chloride (1.04 g) and one drop of dimethylformamide. The mixture was stirred at room temperature for 18 hours to yield a clear solution. The volatile material was removed under reduced pressure to afford 4-(pyrazol-1-yl)benzoyl chloride as a pale yellow solid (1.58 g), which was utilized without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 16209-00-0, its application will become more common.

Reference of 35691-93-1,Some common heterocyclic compound, 35691-93-1, name is Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate, molecular formula is C8H12N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

step 1 – To a solution of 3,5-dimethyl-lff-pyrazole-4-carboxylic acid ethyl ester (0.2 g, 1.19 mmol) in DMF (10 mL) cooled to O0C was added sequentially NaH (60% in mineral oil, 72 mg, 1.78 mmol) and S-chloro-?-trifluoromethyl-pyridazine (0.22 g, 1.21 mmol; Tetrahedron 1999 55:15067-15070). The resulting mixture was stirred at RT for 3 h then partitioned between EtOAc and saturated aqueous NH4Cl. The layers were separated and the aqueous layer was extracted twice with EtOAc. The combined extracts were dried (Na2SO4), filtered and evaporated. The residue was purified via Si?2 chromatography eluting with hexane/EtOAc to afford 0.228 g (62%) of 118a.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate, its application will become more common.

Reference of 25016-20-0,Some common heterocyclic compound, 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, molecular formula is C5H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1: Preparation of methyl 1-methyl-1H-pyrazole-3-carboxylate To a solution of 1-methyl-1H-pyrazole-3-carboxylic acid (504 mg, 4 mmol) in MeOH (5 mL) was added SOCl2 (1.4 mL, 20 mmol) at 0 C. The mixture was stirred at r.t overnight then concentrated under reduced pressure. The residue was dissolved in EtOAc, washed with satd. aq. NaHCO3 and concentrated to afford methyl 1-methyl-1H-pyrazole-3-carboxylate. LC-MS: m/z 141 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-pyrazole-3-carboxylic acid, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6825-71-4, name is Ethyl 3,5-diamino-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., Quality Control of Ethyl 3,5-diamino-1H-pyrazole-4-carboxylate

Sodium ethoxide (33.2g) at room temperatureEthanol solution (500mL)3,5-Diamino-1H-pyrazole-4-carboxylic acid ethyl ester (20.8 g) was added in sequence.1,3-Dimethylpyrimidine-2,4(1H,3H)-dione (17.0 g).After the completion of heating to 90 C reaction12 hours.After the reaction is completed,The pH was adjusted to pH 7 with 1N hydrochloric acid at room temperature.Collect solids,Ethanol wash,Dry to give the title compound (18.4 g).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 5203-77-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5203-77-0, name is 1,3-Dimethyl-1H-pyrazol-5-ol belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Intermediate 9 (4 mmol), dissolved in dry dichloromethane( 60 mL), and DCC (4.8 mmol) were mixed together and stirred at room temperature for 1 h. Then 1,3-dimethyl-1H-pyrazol-5-ol (4 mmol) and DMAP (0.4 mmol) were added to the above solution,and stirred for a further 24-36 h at room temperature. After adding dichloromethane (30 mL), the resultant mixture was washed sequentially with 2 N hydrochloric acid (100 mL), saturated NaHCO3 and saturated brine and dried over anhydrous sodium sulfate.The residue solution was evaporated in vacuum and purified by silica gel column chromatography using gradient elution of ethyl acetate/hexane (V/V = 1/2) to obtain the desired intermediate 10.

The synthetic route of 1,3-Dimethyl-1H-pyrazol-5-ol has been constantly updated, and we look forward to future research findings.