In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 25016-20-0
Acid R2b (8.2 mg, 0.065 mmol, 1.3 equiv) is dissolved in DMF (0.5 mL), then TEA (35 muIota_, 0.25 mmol, 5.0 equiv) is added followed by TBTU (19 mg, 0.060 mmol, 1.2 equiv). The solution is stirred for 15 mins, after which the amine hydrochloride Da (37 mg, 0.050 mmol) is added in DMF (0.5 mL). The solution is stirred at RT for 16 h. Water (2 mL) is added and the organic layer is extracted with EtOAc (3 x5 mL). The solvent is then evaporated and purified on prep HPLC (MeCN:H20, 0.1% TFA). The pure fractions are combined, concentrated, frozen and lyophilized to provide compound 1003. FIA M.S.(electrospray): 806.4 (M+H)+ Retention time (min) = 5.5 min1H NMR (400 MHz,DMSO-d6): delta 11.03 (s, 1H) , 8.81 (s, 1H), 7.83 (d, 1H, J = 8.8 Hz), 7.78-7.74 (m, 2H), 7.08 (d, 1H, J = 9.3 Hz), 6.60 (d, 1H, J = 2.3 Hz), 6.37 (s, 1H), 5.67-5.58 (m, 1H), 5.53-5.42 (m, 2H), 5.14 (dd, 1H, J = 9.5, 9.2 Hz), 4.64-4.57 (m, 1H), 4.51 (d, 1H, J= 11.6 Hz), 4.38 (dd, 1H, J= 9.4, 7.0 Hz), 4.01 (dd, 1H, J = 11.8, 3.5 Hz), 3.89 (s, 3H), 3.88 (s, 3H), 2.96-2.88 (m, 1H), 2.65-2.57 (m, 1H), 2.44 (s, 3H), 2.40-2.28 (m, 2H), 2.00-1.89 (m, 1H), 1.88-1.77 (m, 1H), 1.62-1.51 (m, 3H), 1.50-1.33 (m, 11H), 1.31-1.19 (m, 2H), 1.14-0.98 (m, 4H).
The synthetic route of 25016-20-0 has been constantly updated, and we look forward to future research findings.