Tag: M.W:100-200

Related Products of 84547-61-5, The chemical industry reduces the impact on the environment during synthesis 84547-61-5, name is (1-Methyl-1H-pyrazol-5-yl)methanol, I believe this compound will play a more active role in future production and life.

To a solution of (l-methyl-lH-pyrazol-5-yl)methanol (500 mg, 4.46 mmol) in anhydrous dichloromethane (20 mL) was added PBr3 (1.21g, 4.46 mmol) at 0 C. The mixture was purged with nitrogen and stirred at room temperature for 12 h. The reaction mixture was adjusted to pH -8.5 with saturated aqueous sodium bicarbonate, and then was extracted with dichloromethane (10 mL x 3). The combined organic phase was dried by anhydrous sodium sulphate, filtered and concentrated. The residue was purified by preparative TLC (petroleum ether/ acetic ester =5: 1) to afford the title compound an off-white oil (500 mg, 64%) m/z 174.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (1-Methyl-1H-pyrazol-5-yl)methanol, other downstream synthetic routes, hurry up and to see.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5334-39-4, name is 3-Methyl-4-nitro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 3-Methyl-4-nitro-1H-pyrazole

To a solution of 5 -methyl-4-nitro-l -(oxetan-3 -yl)-l H-pyrazole and 3-methyl-4-nitro-l- (oxetan-3-yl)-l H-pyrazole (0.137 g, 0.75 mmol) in ethanol (2 mL) was added Pd-C (10 wt%, 0.10 g). The mixture was stirred under a hydrogen atmosphere for 24 hours. The reaction was filtered through Celite and concentrated to give a mixture of 5 -methyl- 1 -(oxetan-3 -yl)-lH- pyrazol-4-amine and 3 -methyl- 1 -(oxetan-3 -yl)-lH-pyrazol-4-amine (83 mg, 73%), which were used together in the following Examples. Additional intermediates made using the above procedure are shown in Table 2 below.

According to the analysis of related databases, 5334-39-4, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5775-82-6, name is 4-Bromo-1,3-dimethyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 4-Bromo-1,3-dimethyl-1H-pyrazole

Into a dry flask under N2 is added dry diethyl ether (150 mL) and 1 ,3-dimethyl-4- bromopyrazole (5g, 28.6 mmol, Combi-Blocks). The mixture is cooled to -78C in a dry ice/acetone bath. To this solution is added f-BuLi (37 mL, 62.9 mmol, 1.7 M in pentane) over 5 min, which is allowed to stir for 30 min at -78 C. 2-isopropoxy-4,4,5,5- tetramethyl-1 ,3,2-dioxaborolane (6.4 mL, 31.4 mmol) is added in one portion via syringe. Stirring is continued at -78 C for 15 min. The reaction mixture is allowed to warm to RT and is then stirred for 30 min. The reaction mixture is poured into saturated NH4CI, then extracted with EtOAc (3x). The combined organic layers are dried (Na2S04), filtered and evaporated under reduced pressure. The residue is dissolved in hexanes (6 mL). The solvent is evaporated under reduced pressure and then dried under high vacuum for 48 h to provide boronate ester 24a.

According to the analysis of related databases, 5775-82-6, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 42098-25-9, name is 5-Chloro-1-methyl-4-nitro-1H-pyrazole, A new synthetic method of this compound is introduced below., Recommanded Product: 42098-25-9

General procedure: KO’Bu (938 mg, 8.36 mmol) was added to a stirred solution of 5-chloro-l-methyl-4- nitro-lH-pyrazole (900 mg, 5.57 mmol) and cyclopropanol (970.713 mg, 16.713 mmol) in MeCN (7.27 mL) at rt. Addition was done portionwise. The mixture was stirred at rt for 3hours. Water was added and the mixture acidified with 3N HCl(aq). The reaction mixture was extracted with DCM, dried over MgS04, filtered and evaporated. A purification was performed via preparative LC (Stationary phase: irregular SiOH 15- 40muiotaeta 80g GraceResolv, Mobile phase: gradient from 100% DCM to 98% DCM, 2% MeOH, 0, 1% NH4OH) to afford intermediate 620 (470 mg, yield 46 %).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25016-09-5, name is 1,3-Dimethyl-1H-pyrazole-5-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H8N2O

151. (+)-2- 3,4-trans)-l-gi,3-dimethyl-lH-pyrazol-5-yl)methyl)-4- methylpyrrolidin-3-yl)-7-ftetrahydro-2H-pyran-4-yl)imidazo[5,l- 1 [l,2,41triazin- 4(3H)-one [1110] To a stirred solution of (-)-2-((3,4-trans)-4-methylpyrrolidin-3-yl)-7- (tetrahydro-2H-pyran-4-yl)imidazo[5,l- J[l,2,4]triazin-4(3H)-one (80 mg, 0.26 mmol) in MeOH (10 mL) was added l,3-dimethyl-lH-pyrazole-5-carbaldehyde (39.2 mg, 0.31 mmol) at room temperature and stirred for 2 h under argon atmosphere. To the resulting solution was added NaCNBH3 (49.9 mg, 0.74 mmol) and stirring was continued for another 8 h at room temperature. The volatiles were evaporated under reduced pressure. The residue was diluted with water and extracted with CH2CI2 (2 x 20 mL). Combined organic layer was dried over sodium sulphate, filtered and concentrated in vacuo to obtain the crude product. The crude material was purified by silica gel column chromatography to afford (+)-2-((3,4-trans)-l-((l,3-dimethyl-lH- pyrazol-5-yl)methyl)-4-methylpyrrolidin-3-yl)-7-(tetrahydro-2H-pyran-4- yl)imidazo[5,l- J[l,2,4]triazin-4(3H)-one (40 mg, 37%) as an off-white solid; 1H- NMR (DMSO-d6, 400 MHz): delta 11.65 (bs, 1H), 7.62 (s, 1H), 5.89 (s, 1H), 3.96-3.91 (m, 2H), 3.67 (s, 3H), 3.59 (s, 2H), 3.50-3.47 (m, 2H), 3.41-3.39 (m, 1H), 2.94-2.85 (m, 2H), 2.81-2.79 (m, 2H), 2.65-2.61 (m, 1H), 2.25-2.24 (m, 1H), 2.14 (s, 3H), 1.89- 1.82 (m, 4H), 1.09 (d, 3H); Mass (ESI): 412.3 [M++l]; LC-MS: 98.59%; 412 (M++l); (column; X-bridge C-18, (50×3.0 mm, 3.5mu); RT 1.74 min. 0.05% TFA in water: ACN; 0.8 ml/min); UPLC (purity): 99.67%; (column; Acquity BEH C-18, 50×2.1 mm, 1.7mu; RT 1.18 min. 0.025% TFA (Aq): ACN; 0.50 ml/min.; Chiral HPLC: 98.34%, R,= 11.21 min (Chiralpak IA, 250 x 4.6mm, 5mu; mobile phase (A) 0.1% DEA in n-Hexane (B) DCM:MeOH (80:20) (A: B : 80:20); flow Rate: 1.00 mL/min); Optical rotation [a]D2: + 21.85 (c = 0.25, DCM); TLC: 5% MeOH/DCM (Rf: 0.5).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 25016-09-5.

Related Products of 4149-06-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4149-06-8, name is 3-Amino-1-phenyl-1H-pyrazol-5(4H)-one, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: The mixture of alpha,beta-unsaturated ketone 1, or 4 (1.0 mmol), 3-amino-1-phenyl-1H-pyrazol-5(4H)-one 2 (1.0 mmol), p-TSAxH2O (0.3mmol), MeCN (4mL), H2O (4mL) was put in a reaction flask under 80 C about 1-3 h (monitored by TLC). After completion, the reaction mixture was cooled to room temperature and the products would be precipitated out at same time. Then, it was filtered, washed thoroughly with MeCN. The products were recrystallized from DMF.

The chemical industry reduces the impact on the environment during synthesis 3-Amino-1-phenyl-1H-pyrazol-5(4H)-one. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-(Furan-2-yl)-1H-pyrazol-3-amine

A solution of 3-amino-5-(2-furyl)pyrazole (162 mg, 1.09 mmol) and DIPEA (0.19 mL, 1.09 mmol) in THF (5 mL) was added dropwise to a solution of cyanuric chloride (200 mg, 1.09 mmol) in THF (16.0 mL) at 0 0C. The reaction mixture was stirred at 0 C to room temperature for 2 hours. Then, 1-metyl piperazine (0.12 mL, 1.09 mmol) and DlPEA (0.19 mL, 1.30 mmol) were added to the mixture. The mixture was allowed to stir at room temperature for 3 hours. The solids were filtered off to give compound 11 as white solid (1 10 mg, 14 %). %). 1H NMR (400 MHz, DMSOd6) delta 12.92 (s, IH, NH), 10.38 (s, IH, NH), 7.76 (s, IH, Ar-H), 6.816.61 (m, 3H, Ar-H), 3.77-3.72 (m, 4H, 2CH2), 2.38-2.35 (m, 4H, 2CH2), 2.21 (2, 3H, CH3); ESI-MS: calculated for (C15Hi7ClN8O) 360, found 361 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 5334-39-4, name is 3-Methyl-4-nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5334-39-4, Recommanded Product: 5334-39-4

Added 3-bromooxetane (451 ul, 5.901 mmol) to a mixture of 3-methyl-4-nitro-1 H-pyrazole (500 mg, 3.934 mmol) and cesium carbonate (2.564 g, 7.868 mmol) in DMF (5 mL) and stirred at 70 C for 6 d. Added ether (50ml_) and filtered off the residues. Removed the solvent from the filtrate in vacuo and purified the residue by flash chromatography using dichloromethane/ethyl acetate (3/7) to give the titled compound (589 mg, 82%). LCMS (Method 1 ) Rt 1.865 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Methyl-4-nitro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Application of 37622-90-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 37622-90-5, name is Ethyl 4-pyrazolecarboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of ethyl-1H pyrazole carboxylate (5.0 g, 3.7mmol) in DMF (50 mL), Cs2CO3 (23 g, 71.35mmol) and tert-butyl 4-((methylsulfonyl)-oxy) piperidine-1-carboxylate (9.9 g, 35.6 mmol) were added at 5 C and reaction mixture was stirred at 90 C overnight. The completion of the reaction was confirmed by TLC. The reaction mixture was poured into ice cold water. The resulting solid was filtered, washed with water (50 mL) and dried under reduced pressure. It was used in the next step without any further purification. Yield: 87% (10 g, off white solid). 1H NMR (400 MHz, DMSO-d6 : delta 8.39 (s, 1 H), 7.87 (s, 1 H), 4.45-4.39 (m, 1 H), 4.21 (q, J = 7.2 Hz, 2H), 4.05-4.02 (m, 2H), 2.01 -1.98 (m, 2H), 1.85-1.78 (m, 2H), 1.42 (s, 9H), 1.26 (t, J = 7.2 Hz, 3H). LCMS: (Method A) 222.0 (M-Boc), Rt. 2.77 min, 92.86% (Max).

The synthetic route of Ethyl 4-pyrazolecarboxylate has been constantly updated, and we look forward to future research findings.

Reference of 473528-88-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 473528-88-0, name is 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

4-Bromo-2-methyl-2H-pyrazole-3-carbaldehyde (1.00 g; 5.29 mmol) is dissolved in 5.0 ml of anhydrous THF and cooled down to -78 C. Phenylmagnesium chloride 2 mol/l (6.61 ml; 13.2 mmol) is added and the reaction mixture is stirred for 1 hour. It is warmed up to 0 C. and is quenched carefully with water, then extracted with DCM. The organic layers are pooled, dried over MgSO4 and purified by using reversed phase chromatography under basic conditions. Yield: 82% (1.16 g; 4.35 mmol);HPLC-MS: (M+H)+= 267; tRet=1.59 min; method FECBM3ESI.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde, other downstream synthetic routes, hurry up and to see.