Category: 84547-61-5

Reference of 84547-61-5, The chemical industry reduces the impact on the environment during synthesis 84547-61-5, name is (1-Methyl-1H-pyrazol-5-yl)methanol, I believe this compound will play a more active role in future production and life.

Production Example 32 2-[(1-Methyl-1H-pyrazol-5-yl)methoxy]-5-(trifluoromethyl)pyridine Under a nitrogen atmosphere, a mixture of (1-methyl-1H-pyrazol-5-yl)methanol (200 mg), 2-chloro-5-(trifluoromethyl)pyridine (389 mg), palladium(II) acetate (40 mg), cesium carbonate (870 mg), rac-2-(di-t-butylphosphino)-1,1′-binaphthyl (71 mg) and toluene (9.0 mL) was stirred at 100 C. for 2.5 hours. Thereafter, the reaction solution was diluted with diethyl ether, and was then filtrated with Celite. The filtrate was concentrated under a reduced pressure. The residue was purified by column chromatography (silica gel cartridge, hexane:ethyl acetate=85:15 to 50:50), so as to obtain the title compound (310 mg) in the form of a light yellow oily substance. 1H NMR (200 MHz, CHLOROFORM-d) delta ppm 3.95 (s, 3H) 5.44 (s, 2H) 6.36 (d, J=1.76 Hz, 1H) 6.85 (d, J=8.79 Hz, 1H) 7.45 (d, J=2.20 Hz, 1H) 7.80 (dd, J=8.79, 2.64 Hz, 1H) 8.47 (s, 1H); MS (ESI pos.) m/z: 258 [M+H]+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (1-Methyl-1H-pyrazol-5-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD; Nakamura, Toshio; Sakagami, Kazunari; Konishi, Kazuhide; Yamamoto, Kanako; Masuda, Seiji; Matsuda, Yohei; Okada, Kumiko; Shibata, Tsuyoshi; Ohta, Hiroshi; Yasuhara, Akito; Kawamoto, Hiroshi; US2013/123500; (2013); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 84547-61-5, name is (1-Methyl-1H-pyrazol-5-yl)methanol belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Quality Control of (1-Methyl-1H-pyrazol-5-yl)methanol

A solution of (1 -methyl- lH-pyrazol-5-yl)methanol (1.2 g, 10.71 mmol) in dichloromethane (25 mL) was treated with thionyl chloride (1.9 mL) at room temperature for 2 hours. Then the reaction was quenched by the addition of water (20 mL) and neutralized with saturated aqueous sodium carbonate. The organic layer was separated and the aqueous layer extracted with dichloromethane (3 x 20 mL). The combined organic layer was dried over by anhydrous sodium sulfate. The solids were filtered out and the filtrates were concentrated under reduced pressure to afford 5-(chloromethyl)-l -methyl-lH-pyrazole as light yellow oil (800 mg, 57 %). (ES, m/z): [M+H]+ 131.0 *H NMR (300 MHz, CDC13) delta 7.41 (d, 7 = 1.8 Hz, 1H), 6.27 (d, 7 = 1.8 Hz, 1H), 4.61 (s, 2H), 3.93 (s, 3H)

The synthetic route of 84547-61-5 has been constantly updated, and we look forward to future research findings.

Related Products of 84547-61-5, The chemical industry reduces the impact on the environment during synthesis 84547-61-5, name is (1-Methyl-1H-pyrazol-5-yl)methanol, I believe this compound will play a more active role in future production and life.

To a solution of (l-methyl-lH-pyrazol-5-yl)methanol (500 mg, 4.46 mmol) in anhydrous dichloromethane (20 mL) was added PBr3 (1.21g, 4.46 mmol) at 0 C. The mixture was purged with nitrogen and stirred at room temperature for 12 h. The reaction mixture was adjusted to pH -8.5 with saturated aqueous sodium bicarbonate, and then was extracted with dichloromethane (10 mL x 3). The combined organic phase was dried by anhydrous sodium sulphate, filtered and concentrated. The residue was purified by preparative TLC (petroleum ether/ acetic ester =5: 1) to afford the title compound an off-white oil (500 mg, 64%) m/z 174.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (1-Methyl-1H-pyrazol-5-yl)methanol, other downstream synthetic routes, hurry up and to see.