Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 75415-03-1, name is 2-(1H-Pyrazol-3-yl)pyridine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 75415-03-1, Formula: C8H7N3

CuCl2 ¡¤ 2H2O, 2- (1H-pyrazol-3-yl) pyridine in a molar ratio of 1: 0.5Were added to the reactor liner,And add 17ml of acetone to the reactor tank, sealed,The reaction at a temperature of 160 72h. Naturally cooled to room temperature,Get the chemical formula C16H12N6C14Cu2 crystal, yield:70% (calculated as CuCl2 ¡¤ 2H2O).After the complex is excited by the light of lambdaex = 325nm,A strong characteristic fluorescence appears at lambdaem = 365 nm.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(1H-Pyrazol-3-yl)pyridine, and friends who are interested can also refer to it.

Application of 25016-12-0,Some common heterocyclic compound, 25016-12-0, name is 1,3-Dimethyl-1H-pyrazole-4-carbaldehyde, molecular formula is C6H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(4) 6.3 g of 1,3-dimethyl-1H-pyrazole-4-carbaldehyde (0.052 mol) and2.9 g of ethyl isocyanate (0.026 mol)Add 30mL of water,And heated to 40 C in the air and stirred for 3 hours;After the reaction, add 50% sodium hydroxide aqueous solution to the reaction mixture and mix well.It was then extracted with dichloromethane to remove impurities;The aqueous phase was adjusted to pH = 2-3, filtered, the filter cake was washed, and the solid was collected.4.9 g of 1,3-dimethyl-1H-pyrazole-4-carboxylic acid was obtained; the purity was 99% and the yield was 79%.

The synthetic route of 25016-12-0 has been constantly updated, and we look forward to future research findings.

Reference of 288148-34-5, The chemical industry reduces the impact on the environment during synthesis 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, I believe this compound will play a more active role in future production and life.

General procedure: Allylamine (1.05 equiv) and triethylamine (1.1 equiv) were added in CH2Cl2 to a solution of sulfonyl chloride (1 equiv) in CH2Cl2 (2.5mL/mmol). The reaction was stirred at room temperature for 1 h, then washedwith sat. NH4Cl solution and brine. The organic phase was dried over MgSO4, filtered and concentrated to give the following sulfonylchlorides, which were used without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-pyrazole-4-sulfonyl chloride, other downstream synthetic routes, hurry up and to see.

Application of 5334-39-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5334-39-4, name is 3-Methyl-4-nitro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

To a stirred of solution of 3-methyl-4-nitro-lH-pyrazole (0.3 g, 2.4 mmol) in DMF (10 mL) was added potassium carbonate (0.4 g, 2.9 mmol) and 2-iodopropane (0.72 mL, 7.2 mmol). The solution was stirred at room temperature for 3 hours. The reaction mixture was poured into water (50 mL) and extracted into ether (4 x 30 mL). The combined ethereal extracts were dried (MgSO4) and the solvent removed under vacuum to give a pale yellow oil. Several purifications were performed via column chromatography (SiO2; 200 equiv. 100 % DCM) to give 1 -isopropyl-3 -methyl-4-nitropyrazole (11 mg, 93 % isomeric purity). This was combined with another batch (110 mg, purified identically).

The chemical industry reduces the impact on the environment during synthesis 3-Methyl-4-nitro-1H-pyrazole. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-(Furan-2-yl)-1H-pyrazol-3-amine

To a cold solution of 5-amino-3-(2-furyl)pyrazole (1.00 g g, 6.70 mmol) in THF (20 ml) was added a suspension of sodium hydride (60% in mineral oil, 322 mg, 8.05 mmol) in THF (6 ml) at 0 C. slowly. After stirring at 0 C. for 30 minute, di-tert-butyldicarboxate (1.61 g, 7.38 mmol) was added. The mixture was stirred at 0 C. for 75 minutes. TLC was checked and the starting material was consumed. The reaction mixture was quenched with ice-water, extracted with ethyl acetate/Hexane (90/10, 25 ml x 2). The combined organic was washed by brine, dried over sodium sulfate and concentrated. The residue was triturated with EtOAc (5 ml)-Hexanes (30 ml). The yellow solids were collected by filtration, washed by hexanes to give compound 7 (1.41 g, 84% yield). 1H NMR (400 MHz, DMSO-d6) delta: 7.69 (m, 1H), 6.77 (m, 1H), 6.53 (m, 1H), 6.40 (br, 2H), 5.56 (s, 1H), 1.55 (s, 9H).

The synthetic route of 96799-02-9 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 2075-46-9, name is 4-Nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2075-46-9, Computed Properties of C3H3N3O2

Bromoethanol (1.9 g, 15.57 mmol) and potassium carbonate (2.9 g, 21.12 mmol) were sequentially added to a solution of 4-nitropyrazole (1.6 g, 14.16 mmol) in acetonitrile (20 mL). The suspension was stirred at 60 C. for 16 hours. After cooling to room temperature, the mixture was filtered and the filter cake was washed with acetonitrile (10 mL). The filtrate was concentrated under reduced pressure to give 20-c as a yellow oil (1.1 g, yield 49.5%), which was directly used for the next step without purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Nitro-1H-pyrazole, and friends who are interested can also refer to it.

These common heterocyclic compound, 15801-69-1, name is 4-Bromo-1,3,5-trimethyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 4-Bromo-1,3,5-trimethyl-1H-pyrazole

EXAMPLE 62: 7-Fluoro-4-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,4-dihydropyrazolo[4,3-b]indole [0444] 7-Fluoro-l-(tetrahydro-2H-pyran-2-yl)-l,4-dihydropyrazolo[4,3-]indole (40 mg, 0.154 mmol), 4-bromo-l,3,5-trimethyl-lH-pyrazole (29.2 mg, 0.154 mmol), copper(I) iodide (2.94 mg, 0.015 mmol), Cs2C03 (151 mg, 0.463 mmol) and DMF (lmL) were mixed in an 8 mL tube equipped with a magnetic stir bar to give a brown suspension. The solvent was purged with N2 and the tube was sealed and heated in a microwave for 60 minutes at 22C. More 4-bromo-l,3,5-trimethyl-lH-pyrazole (29.2 mg, 0.154 mmol), copper(I) iodide (2.94 mg, 0.015 mmol) and Cs2C03 (151 mg, 0.463 mmol) were added and the mixture was heated for an additional hour. The reaction mixture was subsequently partitioned between water (25 mL) and EtOAc (50 mL). The layers were separated. The organic layer was washed with brine (20 mL), dried over Na2S04, filtered, and concentrated to yield a brown syrup. The residue was dissolved in MeOH (5 mL) and treated with concentrated HC1 (4 drops). The reaction mixture was stirred overnight and the product was purified by preparative HPLC, eluting with 25-50% ACN in water (containing 0.05% TFA). The pure fractions were lyophilized to give a TFA salt of the title compound as a clear glass (7.8 mg, 13%). 1H NMR (400 MHz, DMSO-de) delta ppm 1.88 (s, 3 H), 2.02 (s, 3 H), 3.76 (s, 4 H), 6.95 – 6.99 (m, 2 H), 7.13 (td, J=9.16, 2.65 Hz, 1 H), 7.52 (s, 1 H), 7.61 (dd, J=8.97, 2.40 Hz, 1 H). MS [M+H]+ calc’d for Ci5Hi4FN5, 284.13; found 284.2.

The synthetic route of 4-Bromo-1,3,5-trimethyl-1H-pyrazole has been constantly updated, and we look forward to future research findings.

Reference of 16209-00-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16209-00-0, name is 4-(1H-Pyrazol-1-yl)benzoic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

PPZ4COOH (1054 mg, 5.61 mmol) (obtained from Wako Pure Chemical) was dissolved in EtOH (60 ml) and 1 ml of was added and refluxed overnight at 100 C to obtain PPZ4COOEt (956.8 mg, 4.42 mmol). PPZ4COOEt (956.8 mg, 4.42 mmol) and iridium (III) chloride trihydrate ( (790 mg, 2.24 mmol) were added to 2-ethoxyethanol (2 EtOEtOH, 60 ml) and deionized water (20 ml) & refluxed overnight at 140 C and then filtered, PPZ4COOEt chlorine bridged binuclear complex (1.4 g, 1.06 mmol) was obtained. And added to 5 – mesityl dipyrromethane (290 mg, 1.10 mmol), 2,3 – dichloro – 5, 6 – dicyano – 1, 4-benzoquinoline (DDQ) (250 mg, 1.10 mmol) tetrahydrofuran and stirred at room temperature for 1 hour, then potassium carbonate ( ) (1 g, 7.23 mmol) was added and stirred again for 15 minutes and further PPZ4COOEt chlorine bridged binuclear complex (730 mg, 0.055 mmol)) was added and the mixture was refluxed overnight at 100 C in a nitrogen gas atmosphere, and the resultant product was washed with chloroform, filtered and the raw material was removed by column chromatography (developing solvent: chloroform: ethyl acetate = 9: 1), and then purified by recycling preparative HPLC (Japan Analytical Industry, LC 9225 NEXT) to obtain PPZ4COOEtMD. Thereafter, the solution was refluxed overnight at 85 C using a large excess amount of lithium hydroxide monohydrate (LiOH ¡¤ H 2 O) in THF: 3: 1: 3 solution, then 0.1 M HCl was used until the pH was about 1 , and then liquid-separated with chloroform to obtain PPZ4COOHMD (173 mg, 0.21 mmol). N-hydroxysuccinimide (NHS: 34.5 mg, 0.30 mmol), 1-ethyl-3- (3- dimethylaminopropyl) carboximide hydrochloride (EDCHCl: 57.5 mg, 0.30 mmol), N, N-dimethylformamide (DMF) were added to PPZ4COOHMD (83 mg, 0.10 mmol), and the mixture was stirred overnight under a nitrogen atmosphere. Thereafter, trimethylamine was added in a large excess amount and the mixture was stirred overnight, and the obtained product was purified using column chromatography (eluent: chloroform: methanol = 97: 3, filler: alumina) to obtain the desired product PPZ4DMMD (60 mg, 0.062 mmol).

The synthetic route of 4-(1H-Pyrazol-1-yl)benzoic acid has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6314-23-4, name is 2-(1-Pyrazolyl)ethanol, This compound has unique chemical properties. The synthetic route is as follows., name: 2-(1-Pyrazolyl)ethanol

A mixture of 2- (LH-PYRAZOL-1-YL) ethanol (6.76 g) and potassium tert-butoxide (6.75 g) in tetrahydrofuran (100 ml) was stirred at ambient temperature for an hour. A solution of 1-fluoro-4-nitrobenzene (7.1 g) in tetrahydrofuran (5 ml) was added to the above mixture and refluxed under stirring for 2.5 hours. The reaction mixture was poured into a mixture of ethyl acetate and water, and the organic layer was washed with brine and dried over magnesium sulfate. The solvent was concentrated in vacuo and the precipitate was collected by filtration to give 1- [2- (4-NITROPHENOXY) ETHYL]-LH-PYRAZOLE (10.75 G). 1H-NMR (DMSO-d6): 8 4. 47-4.60 (4H, m), 6.27 (1H, m), 7.08-7. 16 (2H, m), 7.49 (1H, d, J=1.7 Hz), 7.81 (1H, d, J=2.0 Hz), 8.16- 8.23 (2H, m)

According to the analysis of related databases, 6314-23-4, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 89717-64-6 as follows. Recommanded Product: 4-Bromo-3-nitro-1H-pyrazole

To a solution of 2-hydroxy-5-(thfluoromethoxy)phenylboronic acid (Preparation 23, 20.5 g, 92.4 mmol) and 4-bromo-3-nitro-1 -(tetrahydro-2H-pyran-2-yl)-1 H-pyrazole or 4- bromo-5-nitro-1 -(tetrahydro-2H-pyran-2-yl)-1 H-pyrazole (Preparation 22, 22.7 g, 82.2 mmol) in 1 ,2-dimethoxyethane (300 ml_) and 2 M potassium carbonate in water (1 17 ml_, 212 mmol) was added tetrakis(triphenylphosphine)palladium(0) (5.0 g, 4.3 mmol). The solution was sparged with argon (x 3) and heated at 80 C for 8 hours. The reaction mixture was cooled to ambient temperature and the layers separated. The aqueous phase was washed with ethyl acetate (x 2). The combined organic phase was dried over anhydrous magnesium sulfate and concentrated in vacuo. The residue was purified by silica gel column chromatography (0 to 30% ethyl acetate in hexanes gradient elution) and concentrated in vacuo. Excess hexanes was added to the residue and the resulting solid was collected by filtration and dried in vacuo to afford the title compound as off white crystals (19.5 g).1H NMR (300 MHz, d6-DMSO): delta 1 .46-1 .78 (m, 3H), 1 .87-2.20 (m, 3H), 3.69 (m, 1 H), 3.97 (d, 1 H), 5.56 (d, 1 H), 6.93 (d, 1 H), 7.22 (d, 1 H), 7.31 (s, 1 H), 8.33 (s, 1 H), 10.19 (br s, 1 H).LCMS Rt = 1 .77 min MS m/z 372 [M-H]-

According to the analysis of related databases, 89717-64-6, the application of this compound in the production field has become more and more popular.