Tag: M.W:100-200

1246471-38-4, name is Ethyl 3-Cyclopropylpyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 1246471-38-4

To a solution of 4,4,5,5-tetramethyl-2-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1,3,2-dioxaborolane (1.03 g, 2.45 mmol) in pyridine (5 mL) were added ethyl 3-cyclopropyl-1H-pyrazol-4-carboxylate (0.53 g, 2.94 mmol) and copper(II) acetate monohydrate (0.25 g, 1.23 mmol), and the mixture was stirred overnight at 55C. The reaction mixture was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate_hexane=1:4) to give ethyl 3-cyclopropyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxylate (990 mg, yield 86%) as a solid and ethyl 5-cyclopropyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxylate (20 mg, yield 2%) as an oil. ethyl 3-cyclopropyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxylate (Reference Example 26) 1H-NMR (CDCl3) delta: 1.00-1.10 (2 H, m), 1.10-1.18 (2 H, m), 1.39 (3 H, t, J = 7.2 Hz), 2.57-2.70 (1 H, m), 4.29 (2 H, s), 4.35 (2 H, q, J = 7.2 Hz), 7.02 (1 H, s), 7.33-7.41 (2 H, m), 7.41-7.56 (3 H, m), 7.56-7.64 (2 H, m), 8.41 (1 H, s). ethyl 5-cyclopropyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxylate (Reference Example 27) 1H-NMR (CDCl3) delta: 0.59-0.71 (2 H, m), 0.77-0.91 (2 H, m), 1.32-1.45 (3 H, m), 1.88-2.01 (1 H, m), 4.22-4.39 (4 H, m), 7.08 (1 H, s), 7.30-7.56 (6 H, m), 7.74 (1 H, d, J = 8.0 Hz), 8.07 (1 H, s).

The synthetic route of 1246471-38-4 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 139756-02-8, name is 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide, A new synthetic method of this compound is introduced below., name: 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide

General procedure: A mixture of 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide 1a (1.0 mmol), Ketones 2(1.0 mmol) and InCl3 (10 mol%,) in acetonitrile (6 mL) was stirred at room temperature for the time indicated in Table 3. After completion of the reaction (indicated by TLC) the reaction mixture was filtered and wash with acetonitrile (2 X 5 mL) to remove the insoluble catalyst. The filtrate was collected and concentrated under vacuum. The solid isolated was triturated with MTBE (10 mL), filtered and dried to give the desired product.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 51985-95-6, These common heterocyclic compound, 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A) methyl 5-(4-((tert-butyl(dimethyl)silyl)oxy)phenoxy)-1-methyl-1H-pyrazole-3-carboxylate (1089) A mixture of 660 methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate (2.68 g), 661 (4-((tert-butyl(dimethyl)silyl)oxy)phenyl)boronic acid (4.33 g), 662 copper(II) acetate (4.69 g), 121 triethylamine (3.90 ml), molecular sieves 4A (5.5 g) and 110 dichloromethane (60 ml) was stirred at room temperature for 15 hr. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate) to give the 663 title compound (600 mg). 1H NMR (400 MHz, CDCl3) delta 0.20 (6H, s), 0.99 (9H, s), 3.83 (3H, s), 3.89 (3H, s), 6.03 (1H, s), 6.75-6.86 (2H, m), 6.95-7.05 (2H, m).

The synthetic route of 51985-95-6 has been constantly updated, and we look forward to future research findings.

Reference of 2075-46-9, A common heterocyclic compound, 2075-46-9, name is 4-Nitro-1H-pyrazole, molecular formula is C3H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 4-nitro- 1 H-pyrazole (5.0 g, 44.2 mmol) in CH3CN (100 ml) was added 1 -bromo-2-methoxyethane (4.15 ml, 44.2 mmol, 4.15 mL) and K2C03 (12.22 g, 88.4 mmol). The mixture was stirred at 80 C for 12 h. The solvent was removed under reduced pressure. The residue was diluted with water (30 ml) and extracted with EtOAc (3 x 50 ml), the organic layers were combined and washed with brine (20 ml), dried over Na2S04, and concentrated. The resulting residue was purified by FCC (10 – 25 % petroleum ether in ethyl acetate) to give the title compound as a colourless oil (Y = 79 %). H NMR (400 MHz, chlorofomwf) d ppm 8.24 (s, 1H), 8.08 (s, 1H), 4.32 (t, J= 5 Hz, 2H), 3.75 (t, J= 5 Hz, 2H), 3.36 (s, 3H).

The synthetic route of 2075-46-9 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25016-20-0 as follows. Computed Properties of C5H6N2O2

A suspension of the acid (90 g, 0.71 mol) and DMF (1 drop) in thionyl chloride (250 mL) was stirred at reflux under nitrogen for 2 h. The solvent was evaporated from the reaction mixture, the residue azeotroped with toluene (3X200 mL), diluted into toluene (250 mL), added to a suspension OF PD-C (10 wtpercent, 9.3 g) in toluene (500 mL), and the mixture stirred at reflux for 8 h with a gentle flow of hydrogen gas through the suspension. After cooling to room temperature, the suspension was filtered through celite, washed with toluene, and concentrated in vacuo. The residue was fractionally distilled under vacuum to provide the title compound (50 g, 63percent) as a low melting white solid (bp = 92 ¡ãC COMMAT; 8 mmHg)

According to the analysis of related databases, 25016-20-0, the application of this compound in the production field has become more and more popular.

131797-35-8, name is 5-Chloro-3-(trifluoromethyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C4H2ClF3N2

To a solution of 3-bromo-2-chloro-7-(chloromethyl)-5H-[l,3]thiazolo[3,2-a]pyrimidin-5-one (500 mg, 1.59 mmol) in acetonitrile (10 mL) was added 5-chloro-3-(trifluoromethyl)-lH-pyrazole (327 mg, 1.92 mmol), potassium iodide (133 mg, 0.80 mmol), and potassium carbonate (442 mg, 3.20 mmol) The resulting solution was stirred for 2 h at 80 C and cooled. The solid was filtered off and the filtrate was concentrated in vacuo. The residue was purified by flash chromatography on silica gel eluting with ethyl acetate/petroleum ether (1/9) to afford 3-bromo-2-chloro-7-(chloromethyl)-5H-[l,3]thiazolo[3,2- a]pyrimidin-5-one as a brown solid ( 300 mg, 60%). LCMS (ESI): M+H+ = 448.0.

The synthetic route of 131797-35-8 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 100114-57-6 as follows. SDS of cas: 100114-57-6

EXAMPLE 5 [4-(3-Cyclopropyl-pyrazol-1-yl)-2-trifluoromethy-phenyl]-(5H,11H-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl)-methanone In the manner of Example 2, employing (4-fluoro-2-trifluoromethyl-phenyl)-(5H,11H-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl)-methanone (1.42 g), 60% sodium hydride in oil (0.20 g), 3-cyclopropylpyrazole (0.43 g) and dimethylformamide (50 ml), the product (1.22 g) was obtained as a crystalline solid, m.p. 163-164 C.

According to the analysis of related databases, 100114-57-6, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4054-67-5 as follows. name: 3,3′,5,5′-Tetramethyl-1H,1’H-4,4′-bipyrazole

A mixture of H4L (0.05 mmol, 0.023 g), bpz (0.10 mmol, 0.020 g), Co(NO3)26H2O (0.15 mmol, 0.044 g) and 6mL of acetonitrile/H2O (v/v 1:1) was stirred for 30 min and then transferred and sealed in a 25mL Teflon-lined reactor and heated to 120 C for 72 h, and then cooled toroom temperature at a rate of 5 C/h. Red block crystals of 1 were obtained in 58% yield based on cobalt. Calcd (%) for C34H30N4O11Co2, C,51.79; H, 3.84; N, 7.11. Found C, 51.35; H, 3.49; N, 7.01. IR: 3393(vs);3176(m); 2933(m); 2355(m); 1605(v); 1524(m); 1443(v); 1261(m);1128(v); 1037(m); 774(m); 733(m).

According to the analysis of related databases, 4054-67-5, the application of this compound in the production field has become more and more popular.

Synthetic Route of 20154-03-4, These common heterocyclic compound, 20154-03-4, name is 3-(Trifluoromethyl)-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of 10 g (73.5 mmol) 3 -(trifluoromethyl)- 1H- pyrazole (3) in DMSO (150 ml) were added 9.9 g of potassium tert.-butoxide portion wise. After stirring for 5 minutes drop wise addition of 12 ml of iodoethane followed by stirring overnight were conducted. Water was added afterwards and the pH value was adjusted to 3 by using IN HC1. The mixture was diluted with MTBE and extracted two more times with MTBE. The combined organic phase was washed with Na2S203-solution, water and brine yielding 8 g (67 percent) of the ionic liquid 8.

The synthetic route of 20154-03-4 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 2075-46-9, name is 4-Nitro-1H-pyrazole, molecular formula is C3H3N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 2075-46-9

Compound Ia (15.0 g, 133 mmol) was added to a suspension of palladium on carbon 10% (7.0 g, 6.65 mmol) in ethanol (100 mL). The mixture was shaken for 3 hours under hydrogen pressure (40 psi) at room temperature. The catalyst was removed by filtration through a pad of Celite and the solvent was evaporated. Compound Ib was obtained as a burgundy oil (10.5 g, 126 mmol, 95%) which was used in the following step without purification; GC/MS: m/z = 83 (100%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2075-46-9, its application will become more common.