131797-35-8, name is 5-Chloro-3-(trifluoromethyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C4H2ClF3N2
To a solution of 3-bromo-2-chloro-7-(chloromethyl)-5H-[l,3]thiazolo[3,2-a]pyrimidin-5-one (500 mg, 1.59 mmol) in acetonitrile (10 mL) was added 5-chloro-3-(trifluoromethyl)-lH-pyrazole (327 mg, 1.92 mmol), potassium iodide (133 mg, 0.80 mmol), and potassium carbonate (442 mg, 3.20 mmol) The resulting solution was stirred for 2 h at 80 C and cooled. The solid was filtered off and the filtrate was concentrated in vacuo. The residue was purified by flash chromatography on silica gel eluting with ethyl acetate/petroleum ether (1/9) to afford 3-bromo-2-chloro-7-(chloromethyl)-5H-[l,3]thiazolo[3,2- a]pyrimidin-5-one as a brown solid ( 300 mg, 60%). LCMS (ESI): M+H+ = 448.0.
The synthetic route of 131797-35-8 has been constantly updated, and we look forward to future research findings.