Tag: M.W:100-200

Synthetic Route of 13745-59-0, These common heterocyclic compound, 13745-59-0, name is 3-Bromo-1,4-dimethyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 246.la (lOg, 3.36mmol, 1.Oeq) and 3-bromo-1,4-dimethyl-1H-pyrazole (0.58g, 3.36mmol, 1.Oeq) in mixture of 1,4-dioxane (8.OmL) and water (2.OmL), potassium carbonate (1 .24g, 9.O2mmol, 2.5eq) was added. Argon waspurged through the reaction mixture for 5 mm. Then, [1,1?-bi s(diphenylphosphino)ferrocene] dichloropalladium(II) complex with CH2C12 (0 .29g, 0.33 mmol, 0. leq) was added and again purged for 5 mm. Reaction mixture was stirred at 110 C for 2h. After completion of the reaction, the reaction mixture was transferred to water and extracted with ethyl acetate. Organic layers were combined, dried over anhydrous Na2SO4, filtered and concentrated in vacuo to get the crude material. This was purified by column chromatography using 12% ethyl acetate in hexane as eluant to obtain 246.1 (0.6g, 39.35%). MS(ES): m/z 266.38 [M+H]t

Statistics shows that 3-Bromo-1,4-dimethyl-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 13745-59-0.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25016-09-5, name is 1,3-Dimethyl-1H-pyrazole-5-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 25016-09-5

Step 3: Preparation of 3-(2,5-dimethyl-2H-pyrazole-3yl)-2-(4-fluoro phenyl) acrylic acid (16) A mixture of compound 15 (1 gram, 8.0 mmol) and 4-fluorophenyl acetic acid (1.24 grams, 8.0 mmol), acetic anhydride (2 mL) and triethylamine (0.84 mL, 6.0 mmol) was refluxed under nitrogen atmosphere for 5-6 h. The excess of acetic anhydride was distilled out at the same temperature. The mixture was then diluted with water (100 mL) and neutralized with 2N hydrochloric acid. The solid precipitated was filtered and dried under vacuum to afford the title compound 3-(2,5-dimethyl-2H-pyrazole-3yl)-2-(4-fluoro phenyl) acrylic acid (16) 1.4 gram as a pale brown solid. Yield: 67%; 1H NMR (200 MHz, DMSO-d6): delta 12.75 (s, D2O exchangeable) 7.66 (s, 1H), 7.26-7.12 (m, 4H), 5.0 (s, H) 3.84 (s, 3H), 2.05 (s, 3H); Mass (CI method, i-butane): 261 (M+1, 80%); IR: numax (KBr, cm-1): 3440, 1695.

According to the analysis of related databases, 25016-09-5, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27258-33-9, name is 1-Methyl-1H-pyrazole-5-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 27258-33-9

General procedure: To the solution of 45.0 g aldehyde 10 (0.363 mol) in 225 cm3 pyridine, 45.4 g malonic acid (0.436 mol) and 0.900 g piperidine (10.9 mmol) were added. The resulting mixture was heated at 70 C for 3 days. The solvent was removed in vacuo, and the residue was triturated with H2O. The precipitate was filtered to give the product 11

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 27258-33-9.

Electric Literature of 23170-45-8, These common heterocyclic compound, 23170-45-8, name is Methyl 3-methyl-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

N2 protection,Methyl-1H-pyrazole-4-carboxylate (0.14 g, 1.0 mmol), CuI (19.1 mg,(0.2 mmol), III5 (0.34 g, 1.2 mmol), (E) -N, N’-dimethyl-1,2-cyclohexylenediamine (28.5 mg, 0.2 mmol) And DMF (3 mL) were added to a 25 mL two-necked flask and reacted at 110 C for 24 h,Cooled to room temperature, diluted with 10 mL of water, extracted with ethyl acetate (15 mL x 3), washed with saturated brine (10 mL), dried over anhydrous magnesium sulfate, the solvent was evaporated under reduced pressure,Silica gel column (V ethyl acetate: V petroleum ether = 4: 1),(0.10 g) of methyl orange 1- (3′-nitro-4′-morpholine-phenyl) -3-methyl-pyrazole-4-carboxylate (IV5)Yield 46.2%.

Statistics shows that Methyl 3-methyl-1H-pyrazole-4-carboxylate is playing an increasingly important role. we look forward to future research findings about 23170-45-8.

Synthetic Route of 25711-30-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25711-30-2, name is 1,5-Dimethyl-1H-pyrazole-4-carbaldehyde belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

1,5 -Dimethyl- leta-pyrazole-4-carbaldehyde (114 mg, 0.92 mmol) was added to a solution of tert-butyl 2-[(4-piperidin-4-ylbenzoyl)amino]phenylcarbamate (289 mg, 0.73 mmol) in dichloromethane (6 ml) followed by acetic acid (50 mul, 0.87 mmol). The reaction mixture was allowed to stir under nitrogen for 2.5 hours. Sodium triacetoxyborohydride (233 mg, 1.10 mmol) was added and the reaction mixture allowed to stir, at ambient temperature, for 18 hours (overnight). Saturated aqueous sodium bicarbonate solution (10 ml) was then added to the reaction and allowed to stir for 15 minutes. The organic phase was separated and the aqueous phase re-extracted with dichloromethane (10 ml). The combined organics were washed with water, dried over magnesium sulphate and evaporated to dryness to afford the product as a colourless gum (308 mg, 84%), which was used without further purification; Mass Spectrum: M+H+ 504.

The synthetic route of 1,5-Dimethyl-1H-pyrazole-4-carbaldehyde has been constantly updated, and we look forward to future research findings.

Reference of 37622-90-5, These common heterocyclic compound, 37622-90-5, name is Ethyl 4-pyrazolecarboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of ethyl 1H-pyrazole-4-carboxylate (L, 4 g; 28.5 mmol) in tetrahydrofuran(50 ml) was added sodium hydride (1.36 g, 28.5 mmol) at 0C. The reaction mixture wasstirred for 1 h. Methyl iodide (6.07 g, 42.8 mmol) was added and the reaction was stirred for 18h at room temperature. The reaction mixture was concentrated under reduced pressure anddiluted with water. The resulting aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with sodium bicarbonate, brine, dried over Na2SO4, filtered and concentrated under vacuum to afford ethyl 1-methyl-i H-pyrazole-4-carboxylate as a yellow liquid (LI; 3.5 g, 77% yield). ?H NMR (400 MHz, CDC13): 7.88 (s, 1H), 7.85 (s, 1H), 4.3110 4.25 (q,J= 7.2 Hz, 2H), 3.9 (s, 3H), 1.35-1.31 (t,J= 7.2 Hz, 3H). MS (M+i) 155.12.

Statistics shows that Ethyl 4-pyrazolecarboxylate is playing an increasingly important role. we look forward to future research findings about 37622-90-5.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 37622-90-5 as follows. Application In Synthesis of Ethyl 4-pyrazolecarboxylate

General procedure: Step 1: Ethyl 1-(4-fluorobenzyl)-1H-pyrazole-4-carboxylate Sodium hydride (60% oil dispersion; (2.869 g, 71.7 mmol)) was added portion wise to a cold (0 C.) solution of ethyl 1H-pyrazole-4-carboxylate (6.7 g, 47.81 mmol) in DMF (70 mL). The mixture was stirred for 1 hour at 0 C. followed by the addition of 1-(bromomethyl)-4-fluoro-benzene (10.85 g, 57.38 mmol). The reaction was warmed to room temperature and stirred for 18 hours. The reaction mixture was poured into water and the resulting precipitate was collected by vacuum filtration, washed with water, and dried under vacuum at 50 C. for 20 hours to afford the title compound, wt. 8.3 g (70% yield); 1H NMR (400 MHz, DMSO-d6) delta 8.47 (d, J=0.7 Hz, 1H), 7.87 (d, J=0.7 Hz, 1H), 7.34 (dd, J=8.6, 5.6 Hz, 2H), 7.18 (t, J=8.9 Hz, 2H), 5.35 (s, 2H), 4.20 (q, J=7.1 Hz, 2H), 1.25 (t, J=7.1 Hz, 3H).

According to the analysis of related databases, 37622-90-5, the application of this compound in the production field has become more and more popular.

Electric Literature of 26621-44-3, A common heterocyclic compound, 26621-44-3, name is 3-Nitro-1H-pyrazole, molecular formula is C3H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under inert gas (eg high purity nitrogen) protection to 10 mlSchlek reaction tube was added 0.02 mmol of water-soluble palladium on water-bound monophosphine salt compound (18), 1.0 mmol of 4-methoxy-2-chloropyridine, 1.5 mmol of 3-nitropyrazole, 3 mmol of potassium carbonate and 5 ml of Water, the reaction tube was replaced with nitrogen three times, and then heated to 100 C with an oil bath under magnetic stirring, and the reaction was refluxed for 24 hours. The oil bath was removed and the reaction was concentrated with a rotary evaporator. The residue was chromatographed on silica gel using ethyl acetate as the developing solvent to give pure product 4-methoxy-2-pyridine-3-nitroPyrazole in 85% yield.

The synthetic route of 26621-44-3 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2644-93-1, name is 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., category: pyrazoles-derivatives

Sodium triacetoxyborohydride (17.5 mg, 0.082 mmol) was added to a solution of piperidin-4-yl-benzothiazole (15 mg, 0.069 mmol, Compound 2h, Step 2) and 1,3,5- trimethyl-1H-pyrazole-4-carbaldehyde (9.5 mg, 0.069 mmol, Bionet) in DCE (340 .iL) at room temperature. After three hours, the reaction was purified directly by flash chromatography (4g silica, 0-10% MeOH/DCM). The title compound was obtained as a yellow solid (15 mg, 65% yield). LCMS (ESI) m/z 341.4 (M+1) retention time 3.2 mm. ?H NMR (300MHz, CD3OD) oe = 7.97-7.89 (m, 2H), 7.52-7.37 (m, 2H), 3.71 (s, 3H), 3.63 (s, 2H), 3.28-3.17 (m, 3H), 2.53 (dt,J=2.3, 11.7 Hz, 2H), 2.28 (s, 3H), 2.24 (m, 2H), 2.22 (s, 3H), 2.09-1.97 (m, 2H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1124-16-9, name is 5-Amino-1-isopropyl-3-methylpyrazole, A new synthetic method of this compound is introduced below., SDS of cas: 1124-16-9

Step 1 To a degassed solution of 2,5-dichloro-4-iodopyridine (8 g, 29.2 mmol), 2-amino-3-fluorobenzonitrile (3.98 g, 29.2 mmol) and potassium triphosphate (18.60 g, 88 mmol) in 1,4-dioxane (60 ml) stirred under nitrogen at the room temperature was added DPEPhos (1.258 g, 2.337 mmol) and palladium acetate (0.262 g, 1.168 mmol) The reaction mixture was stirred at reflux for 18 hr. The reaction mixture was filtered. 3-Methyl-1-(1-methylethyl)-1H-pyrazol-5-amine (4.07 g, 29.2 mmol) and cesium carbonate (28.6 g, 88 mmol) were added. The reaction mixture was degassed and palladium acetate (0.262 g, 1.168 mmol) and DPEPhos (1.258 g, 2.337 mmol) were added. The reaction mixture was refluxed overnight. The reaction mixture was filtered and the solid was dissolved in water, heated to 50 C. and stirred for 10 minutes, then filtered again. 2-[(5-Chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]-3-fluorobenzonitrile (6 g, 15.59 mmol, 53.4% yield) was isolated as an orange solid. 1H NMR (400 MHz, DMSO-d6) d ppm 1.23 (d, J=6.57 Hz, 6H) 2.07 (s, 3H) 4.32 (quin, J=6.57 Hz, 1H) 5.64 (d, J=2.02 Hz, 1H) 5.83 (s, 1H) 7.39-7.58 (m, 1H) 7.63-7.82 (m, 2H) 7.88 (s, 1H) 8.26 (br. s., 1H) 8.41 (br. s., 1H); HPLC Rt=2.35 min, MS (ESI): 385.0 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.