Tag: M.W:100-200

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 146941-72-2, name is 4-Bromo-1-methyl-1H-pyrazol-3-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C4H6BrN3

A) To a solution of 4-bromo-1-methyl-1H-pyrazol-3-amine (310 mg) and triethylamine (0.37 mL) in THF (8.8 mL) was added 4-chlorobutanoyl chloride (0.22 mL) under ice-cooling, and the mixture was stirred at 0 C. for 30 min. To the reaction mixture was added saturated aqueous ammonium chloride solution, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (456 mg). MS (ESI+): [M+H]+280.0.

The synthetic route of 146941-72-2 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 103626-03-5, name is Ethyl 1-methyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 103626-03-5, Product Details of 103626-03-5

To the mixture of ethyl 3-hydroxy-1-methyl-pyrazole-4-carboxylate (200.0 mg, 1.18 mmol) and 1,3-dioxolan-2-ylmethanol (159 mg, 1.53 mmol) in THF (5.0 mL) at room temperature was added tri-N-butylphospine (309 mg, 1.53 mmol) followed by diisopropyl azodicarboxylate (309 mg, 1.53 mmol) dropwise. The resulting mixture was stirred at room temperature for 3 hours and then heated at 70 C. for overnight. The reaction was cooled to room temperature, concentrated, purified by combiflash (12 g silica gel, 0-50% EtOAc/Hexanes). The desired fractions were concentrated to give the title compound. 1H NMR (400 MHz, Chloroform-d) delta 7.80 (s, 1H), 5.24 (t, J=3.9 Hz, 1H), 4.51 (d, J=3.9 Hz, 2H), 4.30 (q, J=7.1 Hz, 2H), 4.07-3.99 (m, 2H), 3.99-3.93 (m, 2H), 3.76 (s, 3H), 1.37 (t, J=7.1 Hz, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 1-methyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.

These common heterocyclic compound, 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 4-Nitro-1H-pyrazole-3-carboxylic acid

Step 1. 4-Nitro-lH-pyrazole-3-carboxylic acid ethyl ester; Thionyl chloride (2.90 ml, 39.8 mmol) was slowly added to a mixture of 4-nitro-3- pyrazolecarboxylic acid (5.68 g, 36.2 mmol) in EtOH (100 ml) at ambient temperature and the mixture stirred for 48 hours. The mixture was reduced in vacuo and dried through azeotrope with toluene to afford 4-nitro-lH-pyrazole-3- carboxylic acid ethyl ester as a white solid (6.42 g, 96%). (1H NMR (400 MHz, DMSO-d6) delta 14.4 (s, IH), 9.0 (s, IH), 4.4 (q, 2H), 1.3 (t, 3H)).

The synthetic route of 4-Nitro-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.

Electric Literature of 13808-64-5, These common heterocyclic compound, 13808-64-5, name is 4-Bromo-3-methylpyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 4554-{7-Methanesulfonyl-5- [(S)-oxan-4-yl(phenyl)methylj -5H-pyrido [3,2-bj indol-3-yl}-3-methyl- 1H-pyrazole (S)-(7-(Methylsulfonyl)-5 -(phenyl(tetrahydro-2H-pyran-4-yl)methyl)-5H- pyrido [3 ,2-b]indol-3 -yl)boronic acid (20.0 mg, 0.0430 mmol) and 4-bromo-3 -methyl-i Hpyrazole (13.9 mg, 0.0860 mmol) were dissolved in in 1.5 mL of dioxane and and 0.2 mLof water. To this was added potassium carbonate (17.9 mg, 0.129 mmol) and PdC12(dppf)-CH2C12 adduct (2.46 mg, 3.02 .imol), and argon was bubbled in while sonicating for 5 mm. The vial was capped, heated at 100 C for 50 mm, and filtered. The crude material was purified via preparative LC/MS (Preparative HPLC Method 1) with the following modifications: Gradient 10-50% B over 40 mm. Fractions containing thedesired product were combined and dried via centrifugal evaporation. The yield of the product was 1.20 mg, and its estimated purity by LCMS analysis was 96%. Two analytical LC/MS injections were used to determine the final purity Injection 1: LC/MS Method 3, HPLC RT = 1.83 mm. Injection 2: LC/MS Method 4, HPLC RT = 2.37 mm. ?H NMR (500MHz, DMSO-d6) oe 8.69 (s, 2H), 8.42 (d, J=8.4 Hz, 1H), 8.27 (br. s., 1H),8.01 (s, 1H), 7.82 (d, J=8.4 Hz, 1H), 7.67 (d, J=7.7 Hz, 2H), 7.36 (t, J=7.5 Hz, 2H), 7.27 (t, J=7.3 Hz, 1H), 5.99 (d, J=i 1.0 Hz, 1H), 3.90 (s, 2H), 3.72 (d, J=9.9 Hz, 2H), 3.60 (br. s., 2H), 3.52 (t,J=ii.2 Hz, 3H), 3.27 (t,J=ii.6 Hz, 1H), 2.43 (s, 3H), 1.85-1.73 (m, 1H), 1.72-1.58 (m, 1H), 1.46-1.27 (m, 1H), 0.89 (d,J=12.i Hz, 1H).

The synthetic route of 13808-64-5 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 57097-81-1 as follows. Recommanded Product: 57097-81-1

General procedure: The properly substituted pyrazole (1.0 equiv) was dissolved in anhyd pyridine. DMAP (0.1 equiv) was added, and the reaction mixture was stirred under N2 for 30 min. The appropriate isocyanate (1.1-1.5 equiv) was then added, and the resulting mixture was stirred for 12 h. The solvent was evaporated under reduced pressure and the crude was purified by silica gel column chromatography, eluting with a mixture cyclohexane/EtOAc.

According to the analysis of related databases, 57097-81-1, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 632365-54-9, name is Methyl 5-amino-1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 632365-54-9, COA of Formula: C5H7N3O2

Step C. Methyl 3-amino-lH-pyrazole 5-carboxylate (325 mg, 2.3 mmol) and methyl acetoacetate (330mg, 2.3 mmol) in methanol (10 mL) were heated to reflux for 2h and cooled down. The resulting precipitate was collected to give white solid product 7-Methyl-pyrazolo[l,5-a]pyrimidine-2,5-dicarboxylic acid dimethyl ester (356 mg, yield 62%). MS (M + H): 250.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 5-amino-1H-pyrazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 57012-20-1, name is (1,3-Dimethyl-1H-pyrazol-5-yl)methanol, This compound has unique chemical properties. The synthetic route is as follows., Formula: C6H10N2O

Example 1.2: Preparation of 2,5-dimethyl-2H-pyrazole-3-carbaldehyde1.3 g of oxalic acid chloride in 40 ml DCM were cooled to -700C and 1 ,6 g DMSO in 10 ml DCM were added dropwise. After 5 min of stirring at -700C 1 g of (2,5-dimethyl- 2H-pyrazol-3-yl)-methanol (example 1.1 ) in 10 ml DCM and 6 g triethylamine were added and the reaction mixture was allowed to warm to about 20 to 25C. After extrac- tion with water the reaction mixture was dried. After removing the solvents in vacuo, the resulting residue was purified by column chromatography over silica with cyclohex- ane/ethylacetate mixtures yielding 0.6 g of the title compound as a yellowish oil. 1H-NMR (CDCI3, delta in ppm): 9.8 (s, 1 H); 6.7 (s, 1 H); 4.1 (s, 3H); 2.3 (s, 3H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 57012-20-1.

Synthetic Route of 15802-80-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 15802-80-9, name is 3-(tert-Butyl)pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 4 Preparation of 5-[3-(1,1-dimethylethyl)-1H-pyrazol-1-yl]-3-[3-(trifluoromethyl)phenyl]-4-oxazolidinone To a solution of 5-hydroxy-3-[3-(trifluoromethyl)phenyl]-4-oxazolidinone (1 g, 4.05 mmol) in tetrahydrofuran (20 mL) under nitrogen at ~0 C., were added 3-(1,1-dimethylethyl)-1H-pyrazole (0.5 g, 4.05 mmol), triphenylphosphine (1.23 g, 4.7 mmol) and diisopropyl azodicarboxylate (0.88 mL, 4.46 mmol). After the addition, the reaction mixture was allowed to warm up slowly to room temperature and stirred at room temperature overnight. The reaction mixture was then concentrated, and the residue was purified by column chromatography (silica gel, ~20% ethylacetate/80% hexanes) to give a crude product. The crude product was further purified by column chromatography (silica gel, ~20% ethyl acetate/~80% hexanes) to give the title compound, a compound of this invention, as a white solid (14 mg) melting at 95-98 C. 1H NMR (CDCl3): delta 1.26 (s, 9H), 5.57 (d, 1H), 5.79 (d, 1H), 6.08 (s, 1H), 6.20 (d, 1H), 7.45-7.6 (m, 3H), 7.8-7.9 (m, 2H).

The chemical industry reduces the impact on the environment during synthesis 3-(tert-Butyl)pyrazole. I believe this compound will play a more active role in future production and life.

These common heterocyclic compound, 4522-35-4, name is 3-Iodo-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 3-Iodo-1H-pyrazole

INTERMEDIATE 29 5-Chloro-4-(3-iodo-lH-pyrazol-l-yl)-2-methoxypyridine A solution of 3-iodo-lH-pyrazole (0.3 g, 1.547 mmol), 5-chloro-2-methoxypyridine- 4-boronic acid (0.377 g, 2.011 mmol), DMAP (0.756 g, 6.19 mmol), copper(II)acetate (0.281 g, 1.547 mmol), and cesium carbonate (1.26 g, 3.87 mmol) in 1,4-dioxane (7.73 mL) was heated at 80 C overnight. The reaction was allowed to warm to room temperature and filtered. The filtrate was diluted with EtOAc and water, and the seperated aq. layer was extracted with EtOAc. The combined organics were dried over MgS04, filtered and concentrated. The residue was purified with flash chromatography (ISCO Combiflash, 24 g, 0-10 % EtOAc in hexanes) to give 5- chloro-4-(3-iodo-lH-pyrazol-l-yl)-2-methoxypyridine, as a white solid. LCMS calc. = 335.93; found = 335.82 (M+H)+. 1H NMR (500 MHz, CDC13): delta 8.25 (s, 1 H); 8.01 (d, J= 2.6 Hz, 1 H); 7.14 (s, 1 H); 6.66 (d, J= 2.5 Hz, 1 H); 3.96 (s, 3 H).

The synthetic route of 3-Iodo-1H-pyrazole has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2075-45-8, name is 4-Bromo-1H-pyrazole, A new synthetic method of this compound is introduced below., Application In Synthesis of 4-Bromo-1H-pyrazole

a) 4-Bromo- 1 -ethyl- 1 H-pyrazoleTo a solution of 4-bromo-l H-pyrazole (5 g, 34 mmol) in DMF were added K2C03 (11.75 g, 85.03 mmol, 2.5 eq.) and iodoethane (8 g, 51 mmol, 1.5 eq.) and the mixture was stirred at RT for 12 h. The mixture was quenched and extracted as in Intermediate Example 5(c). The solvent was distilled off and the crude residue was purified by column chromatography (60-120 silica gel, 40 % ethyl acetate in hexane) to yield the product in 84 % yield (5 g). ? NMR (300 MHz, DMSO-i?): delta 8.02 (s, 1H), 7.55 (s, 1H), 4.15 (q, 2H), 1.37 (t, 3H); LC-MS (ESI): Calculated mass: 175.03;Observed mass: 177.0 [M+H]+ (rt: 0.56 min).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.