Tag: M.W:100-200

Synthetic Route of 180207-57-2, A common heterocyclic compound, 180207-57-2, name is 2-(1H-Pyrazol-4-yl)ethanol, molecular formula is C5H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

SM (0.9 g, 8.03 mmol, 1.0 eq) was added to SOCl2 (3.82 g, 32.11 mmol).Stir at 70 C for 30 minutes.The reaction solution is concentrated and dried to obtainMC18-157-2 (1.0 g, yield 95%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 175137-46-9, category: pyrazoles-derivatives

A mixture of (S)-6-chloro-Lambda/-(l-(4-fluorophenyl)ethyl)-3-nitropyridin-2-aniine (Method 19; 1.74 g, 5.88 mmol), S-cyclopropyl-lH-pyrazol-S-amine (0.91 g, 7.36 mmol), and DIEA (1.28 ml, 7.36 mmol) in W-BuOH (10 ml) was heated in a sealed tube at 160 C for 60 hours. The solvent was removed under reduced pressure and the residue was purified by chromatography (hexane: EtOAc = 1 : 1) to give the title compound as a yellow solid (1.35 g, 60%). NMR (400 MHz) 12.15 (s, IH), 10.43 (br, IH), 9.19 (br, IH), 8.12 (d, J= 9.2 Hz, IH), 7.45 (m, 2H), 7.17 (m, 2H), 6.25 (br, IH), 6.14 (br, IH), 5.45 (m, IH), 1.87 (m, IH), 1.60 (d, J= 6.8 Hz, 3H), 0.95 (m, 2H)5 0.65 (m, 2H). MS: Calcd.: 382; Found: [M+H]+ 383.

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Electric Literature of 118430-73-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 118430-73-2 as follows.

To 1.0 g (6.53 mmol) of 5-tert-butyl-2-methyl-2H-pyrazol-3-ylamine in 10 mL of CH2Cl2 is added 1.37 g (7.17 mmol) of 4-isocyanate-benzoic acid ethyl ester, and the mixture is stirred at 23C for 3 hr. The white solid is filtered and triturated with methylene chloride and then with diethyl ether. The solids are air-dried 1 hr to obtain the title product (2.07 g, 6.01 mmol, 92 % yield, ES+(m/z) 345 [M+H]).

According to the analysis of related databases, 118430-73-2, the application of this compound in the production field has become more and more popular.

10010-93-2, name is 3-Methyl-5-(trifluoromethyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 3-Methyl-5-(trifluoromethyl)-1H-pyrazole

An oven dried resealable Schlenk tube was charged with 5-bromopyridin-2-amine (400 mg, 2.24 mmol), 5-methyl-3-(trifluoromethyl)-1H-pyrazole (340 mg, 2.24 mmol), potassium phosphate (972 mg, 4.49 mmol) and 7 ml dioxane were added. The Schlenk tube was subjected to three cycles of evacuation-backfilling with argon, and copper(I) iodide (65 mg, 0.34 mmol) and N,N’-dimethylcyclohexane-1,2-diamine (55 mul, 0.34 mmol) were added. After three further cycles of evacuation-backfilling with argon, the Schlenk tube was capped and placed in an oil bath at 130 C overnight. The mixture was cooled and was filtered through a plug of Celite. The filtered was concentrated under reduced pressure and the brown crude was purified by flash chromatography (0% to 50%, hexane-ethyl acetate) to give 476 mg (88% yield) of the title compound. LRMS (m/z): 343 (M+1)+.

The synthetic route of 10010-93-2 has been constantly updated, and we look forward to future research findings.

Reference of 4149-06-8, The chemical industry reduces the impact on the environment during synthesis 4149-06-8, name is 3-Amino-1-phenyl-1H-pyrazol-5(4H)-one, I believe this compound will play a more active role in future production and life.

General procedure: The mixture of isatin (1 mmol), 3-amino-1-phenyl-1H-pyrazol-5(4H)-one (1 mmol), 1,2-diarylethan-1-one, 2,3-dihydroinden-1-one (1 mmol) or 3,4-dihydronaphthalen-1(2H)-one (1 mmol), H2O (6 mL), HOAc (2 mL) was put in a reaction flask under 90 C about 5-7 h (monitored by TLC). After completion, the reaction mixture was cooled to room temperature and the products would be isolated out at same time. Then, compound 4 was recrystallized from DMF, however, the pure products of 6 and 8 were filtered from water, dried, without further recrystallization.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Amino-1-phenyl-1H-pyrazol-5(4H)-one, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 55864-87-4, name is Ethyl 4-nitro-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., Quality Control of Ethyl 4-nitro-1H-pyrazole-3-carboxylate

To a mixture of A32 (5.45 g, 29.4 mmol, 1 eq) and 3,4-dihydro-2H-pyran (7.43 g, 88.3 mmol, 8.07 mL, 3 eq) in THE (40 mL) was added TsOH (507 mg, 2.94 mmol, 0.1 eq). The resulting mixture was stirred at 80 C for 16 hours to give a yellow solution. TLC (PE/EtOAc = 3/1) showed the reaction was completed. The reaction mixture was quenched with H20 (100 mL) and extracted with EtOAc (50 mL x 2). The organic layer were washed with brine (20 mL x 3), dried over anhydrous Na2S04, filtered and concentrated under reduced pressure to give a residue. The residue was purified by silica gel column chromatography (Si02, PE/EtOAc = 3:1) to give 7.01 g (yield: 88.4%) of A37 as a yellow oil.

The synthetic route of 55864-87-4 has been constantly updated, and we look forward to future research findings.

Reference of 37622-90-5,Some common heterocyclic compound, 37622-90-5, name is Ethyl 4-pyrazolecarboxylate, molecular formula is C6H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Into a 250-mL 3-necked round-bottom flask purged and maintained with an inert atmosphere of 02, was placed ethyl lH-pyrazole-4-carboxylate (3 g, 21.41 mmol, 1.00 equiv), DCE (50 mL), cyclopropylboronic acid (3.51 g, 40.83 mmol, 1.90 equiv), Na2C03 (4.54 g, 40.8 mmol, 1.90 equiv), Cu(OAc)2 (3.88 g, 21.36 mmol, 1.00 equiv), bipyridine (3.34 g, 21.41 mmol, 1.00 equiv). The resulting solution was stirred for overnight at 70 C and then cooled to room temperature. The solids were filtered out. The filtrate was concentrated under vacuum. The residue was purified via reversed phase column with the following conditions: Column, CI 8 silica gel, 120 g, 20-45 muiotaeta, 100A; Mobile phase: water with 0.5% TFA and CH3CN (5% CH3CN up to 80% in 30 min). The collected fraction was concentrated under vacuum to afford ethyl l-cyclopropyl-lH-pyrazole-4-carboxylate (2.2 g, 57%) as a light yellow solid. MS (ESI, m/z): 181 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 4-pyrazolecarboxylate, its application will become more common.

These common heterocyclic compound, 52867-42-2, name is Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate

Step 2: 2-Methyl-5-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-2H-pyrazole-3-carboxylic acid ethyl ester (3_ 1_3) [00353] Diisopropyl azodicarboxylate (DIAD, 41.6 mL, 205.8 mmol) was added to a solution of 3_41_2 (10.7 g, 68.6 mmol), 2-(tetrahydro-pyran-2-yloxy)- ethanol (17 mL, 102.9 mmol) and triphenylphosphine (53.9 g, 205.8 mmol) at 0C, and the mixture was stirred at room temperature for 16 hours. The reaction mixture was heated at 80C for 16 hours, more 2-(tetrahydro-pyran-2-yloxy)-ethanol (3.75 mL), triphenylphosphine (5.3 g) and diisopropyl azodicarboxylate (3 mL) were added, and the reaction mixture was refluxed for 16 hours, concentrated and treated with diethyl ether and hexanes (2:3, 500 mL) to give a precipitate, which was removed by filtration. The filtrate was concentrated and the residue obtained was purified by column chromatography to give compound 3_41_3 (26.6 g, >100 % yield, contaminated with diisopropyl azodicarboxylate) as a yellow oil. [00354] NMR (400 MHz, CDC13): delta = 1.45-1.90 (m, 6H), 3.52 (d, ]=UA Hz, 1H), 3.79-3.92 (m, 5H), 3.95-4.10 (m, 5H), 4.31 (t, J=4.9 Hz, 2H), 4.69 (t, J=3.5 Hz, 1H), 6.21 (s, 1H).

The synthetic route of Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate has been constantly updated, and we look forward to future research findings.

Synthetic Route of 5744-56-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5744-56-9, name is 1,3-Dimethyl-1H-pyrazole-5-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Example 14; Preparation of (S)-4-(5-chloro-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)-3-ethylmorpholine (n-1) Step 1: Preparation of 1,3-dimethyl-4-nitro-1H-pyrazole-5-carboxylic acid (n-2) To fuming nitric acid (1.26 mL, 29.97 mmol, 2.0 eq.) at 0 C. was slowly added fuming sulfuric acid (9.76 mL, 104.90 mmol, 7.0 eq.) dropwise over 30 minutes. 1,3-Dimethyl-1H-pyrazole-5-carboxylic acid (2.10 g, 14.98 mmol) was then added portion wise, maintaining the internal temperature below 60 C. The reaction mixture was stirred at 60 C. under N2 for 4 h and then cooled to room temperature (RT). The reaction mixture was poured onto ice. Once ice melted the reaction mixture was extracted with EtOAc (3¡Á500 mL). The organic layers were combined and washed with water and brine, dried (Na2SO4), filtered and evaporated in vacuo to give the desired compound as a white solid (2.67 g, 96.1%). 1H NMR (DMSO-d6, 500 MHz) delta ppm 3.87 (s, 3H), 2.39 (s, 3H); TLC (15% MeOH/DCM): Rf=0.12.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Dimethyl-1H-pyrazole-5-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Electric Literature of 4149-06-8, These common heterocyclic compound, 4149-06-8, name is 3-Amino-1-phenyl-1H-pyrazol-5(4H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The mixture of alpha,beta-unsaturated ketone 1, or 4 (1.0 mmol), 3-amino-1-phenyl-1H-pyrazol-5(4H)-one 2 (1.0 mmol), p-TSAxH2O (0.3mmol), MeCN (4mL), H2O (4mL) was put in a reaction flask under 80 C about 1-3 h (monitored by TLC). After completion, the reaction mixture was cooled to room temperature and the products would be precipitated out at same time. Then, it was filtered, washed thoroughly with MeCN. The products were recrystallized from DMF.

Statistics shows that 3-Amino-1-phenyl-1H-pyrazol-5(4H)-one is playing an increasingly important role. we look forward to future research findings about 4149-06-8.