10010-93-2, name is 3-Methyl-5-(trifluoromethyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 3-Methyl-5-(trifluoromethyl)-1H-pyrazole
An oven dried resealable Schlenk tube was charged with 5-bromopyridin-2-amine (400 mg, 2.24 mmol), 5-methyl-3-(trifluoromethyl)-1H-pyrazole (340 mg, 2.24 mmol), potassium phosphate (972 mg, 4.49 mmol) and 7 ml dioxane were added. The Schlenk tube was subjected to three cycles of evacuation-backfilling with argon, and copper(I) iodide (65 mg, 0.34 mmol) and N,N’-dimethylcyclohexane-1,2-diamine (55 mul, 0.34 mmol) were added. After three further cycles of evacuation-backfilling with argon, the Schlenk tube was capped and placed in an oil bath at 130 C overnight. The mixture was cooled and was filtered through a plug of Celite. The filtered was concentrated under reduced pressure and the brown crude was purified by flash chromatography (0% to 50%, hexane-ethyl acetate) to give 476 mg (88% yield) of the title compound. LRMS (m/z): 343 (M+1)+.
The synthetic route of 10010-93-2 has been constantly updated, and we look forward to future research findings.