Adding a certain compound to certain chemical reactions, such as: 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 175137-46-9, category: pyrazoles-derivatives
A mixture of (S)-6-chloro-Lambda/-(l-(4-fluorophenyl)ethyl)-3-nitropyridin-2-aniine (Method 19; 1.74 g, 5.88 mmol), S-cyclopropyl-lH-pyrazol-S-amine (0.91 g, 7.36 mmol), and DIEA (1.28 ml, 7.36 mmol) in W-BuOH (10 ml) was heated in a sealed tube at 160 C for 60 hours. The solvent was removed under reduced pressure and the residue was purified by chromatography (hexane: EtOAc = 1 : 1) to give the title compound as a yellow solid (1.35 g, 60%). NMR (400 MHz) 12.15 (s, IH), 10.43 (br, IH), 9.19 (br, IH), 8.12 (d, J= 9.2 Hz, IH), 7.45 (m, 2H), 7.17 (m, 2H), 6.25 (br, IH), 6.14 (br, IH), 5.45 (m, IH), 1.87 (m, IH), 1.60 (d, J= 6.8 Hz, 3H), 0.95 (m, 2H)5 0.65 (m, 2H). MS: Calcd.: 382; Found: [M+H]+ 383.
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