Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 42098-25-9, name is 5-Chloro-1-methyl-4-nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 42098-25-9, Formula: C4H4ClN3O2

Example 354 5-amino-2-(2,6-difluorophenyl)-N-[1-methyl-5-(9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)pyrazol-4-yl]thiazole-4-carboxamide 354 [1008] RRN No.1703,1706,1708,1710Step A. To a microwave reaction vial was added 5-chloro-1-methyl-4-nitro-1H-pyrazole (141 mg, 0.88 mmol), tert-butyl 9-oxa-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate (200 mg, 0.88 mmol). Ethanol (8 mL) and diisopropylethylamine (0.92 mL, 5.25 mmol) were added and the mixture was irradiated with a microwave for 60 min at 130 C. The mixture was cooled, concentrated and purified via flash chromatography, ethyl acetate/ heptane 0% to 100% to afford yellow oil tert-butyl 7-(2-methyl-4-nitro-pyrazol-3-yl)-9-oxa-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate (202 mg, 65%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloro-1-methyl-4-nitro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Related Products of 5334-43-0, A common heterocyclic compound, 5334-43-0, name is 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile, molecular formula is C10H8N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a stirred solution of the intermediate compounds 1a-1d (1 mmol) and triethylamine (2 mmol) in DMF (12 mL) medium, a mixture of EDCI (1 mmol) and HOBt (1mmol) was added and the reaction mixture was stirred at room temperature for 30 min, then a mixture of compounds 2a-2d (1 mmol) and DMF (5 mL) was added, the reaction was stirred at room temperature. And the reaction progress was monitored by TLC. After completion of the reaction, the product was added into chloroform, then extracted from chloroform with water, and washed successively with 0.2 mol/L hydrochloric acid, water,2 mol/L sodium hydroxide, water, saturated sodium chloride, then dried, concentrated and purified by preparative thin layer chromatography (PE:EA = 8:1) followed by recrystallization from ethanol.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 288148-34-5, These common heterocyclic compound, 288148-34-5, name is 1-Methyl-1H-pyrazole-4-sulfonyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2 1-Methyl-1H-pyrazole-4-sulfonic acid 4-[2-(4-bromo-benzyl)-4,5-dimethyl-thiophene-3-carbonyl]-2-cyclopentyl-phenyl ester At ambient temperature, to a stirred solution of [2-(4-bromobenzyl)-4,5-dimethyl-thiophen-3-yl]-(3-cyclopentyl-4-hydroxy-phenyl)-methanone (0.283 g, 0.603 mmol) in N,N-DMF (3.0 mL) was added 60% sodium hydride/mineral oil (24.1 mg, 0.603 mmol). After 0.5 h, to the reaction was added a solution of 1-methyl-1H-pyrazole-4-sulfonyl chloride (0.120 g, 0.664 mmol) in N,N-DMF (1.3 mL). After 3 h, the reaction was quenched with 1N NaOH (40 mL), extracted with CH2 Cl2, dried (Na2 SO4) and concentrated. Purification on Biotage KP-Sil eluding with 20% acetone/hexane gave 0.202 g (55%) of the title compound as a yellow solid, mp 55-60 C. (DMSO-d6) delta 1.29-1.34 (m, 2 H), 1.59-1.79 (m, 6 H), 1.81 (s, 3 H), 2.28 (s, 3 H), 3.08 (quintet, 1 H), 3.87 (s, 2 H), 3.89 (s, 3 H), 6.98 (d, 2 H), 7.32 (d, 1 H), 7.39 (d, 2 H), 7.53-7.57 (m, 2 H), 7.97 (s, 1 H), 8.62 (s, 1 H). IR (KBr) 3450, 2950, 1650, 1490, 1400, 1370 and 1170 cm-1. mass spectrum (+ESI) m/z 613/615 (M+H).

The synthetic route of 288148-34-5 has been constantly updated, and we look forward to future research findings.

Application of 112029-98-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 112029-98-8, name is (1-Methyl-1H-pyrazol-4-yl)methanol belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

[00775] Compound 58-a was synthesized according to Method A. Amide 58-b was synthesized from compound 58-a and 2-aminopyrazolo[ 1 ,5-a]pyrimidine-3-carboxylic acid according to Method D. Potassium teftbutoxide (0.25 mmol, 1.5 equiv was then suspended in anhydrous tetrahydrofuran (1 mL). A solution of (1-methyl- 1H-pyrazol-4-yl)methanol in tetrahydrofuran (1 mL) was then added and the mixture was heated to 40 ¡ãC. A solution of compound 58-b (0.17 mmol, 1.0 equiv) in tetrahydrofiaran (1 mL) was added and the temperature was increased to 60 ¡ãC. The reaction was heated for 45 mm after which there was no more starting material by LC/MS analysis. The mixture was cooled and poured into brine and then extracted with ethylacetate (2x). The combined organic layers were dried and concentrated onto silica gel (2g). The residue was then purified using flash silica gel chromatography (ISCO, Si-i 2g column, gradient of 0-10percent methanol, methylene chloride). The product containing fractions were then concentrated and further purified using reverse phase HPLC (Interchim-sunfire, gradient of 5- 50percent acetonitrile water, ammonium bicarbonate buffer) to provide compound 67 as the desired product. ESI-MS m/z: 535.4 [M+H]+.

The synthetic route of (1-Methyl-1H-pyrazol-4-yl)methanol has been constantly updated, and we look forward to future research findings.

Electric Literature of 54605-72-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 54605-72-0, name is 1-Phenylpyrazole-4-carboxaldehyde, This compound has unique chemical properties. The synthetic route is as follows.

Step 2: A solution of 4-(Piperazin-1 -yl)quinazoline (1.0 g, 4.7 mmol) and 1 -phenyl-1 H-pyrazole- 4-carbaldehyde (0.81 g, 4.7 mmol) in 1 ,2- dichloroethane (20 ml.) was treated with sodium triacetoxy borohydride (1.5 g, 7 mmol) and the reaction mixture was stirred overnight. The mixture was diluted with dichloromethane (30 ml.) and washed sequentially with 25 ml. portions of 1 M NaOH, water and brine. The organic layer was evaporated and the desired product was purified by column chromatography on silica gel column using ethyl acetate/hexane (10-50%) as the mobile phase the desired product was obtained as a white solid (1.5 g). Mass Spec, M+H = 371.

The chemical industry reduces the impact on the environment during synthesis 1-Phenylpyrazole-4-carboxaldehyde. I believe this compound will play a more active role in future production and life.

Reference of 2075-45-8,Some common heterocyclic compound, 2075-45-8, name is 4-Bromo-1H-pyrazole, molecular formula is C3H3BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 4-bromo-lH-pyrazole (21.6 g, 147 mmol) in dichloromethane (400 mL) from Step 1 was added HCl (4 N in dioxane) (2.204 mL, 8.82 mmol )And ethoxyethylene (12.72 g, 176 mmol). After stirring the mixture for 30 min at rt, the reaction was quenched with aqueous NaHCO3 (30 mL), stirred at rt for 1 h, and the two layers were separated. The organic layer was washed with water, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 28 g of crude product. The material was purified by flash chromatography using silica gel using a hexane / ethyl acetate mixture as a solvate. A portion of the main product containing the uv activity was combined and concentrated in vacuo to afford 13.2 g (41%) of the desired product as a clear oil

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-1H-pyrazole, its application will become more common.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14531-55-6 as follows. Safety of 3,5-Dimethyl-4-nitro-1H-pyrazole

To a solution of 3,5-dimethyl-4-nitro-1H-pyrazole (2.5 g, 17.7 mmol) and caesium carbonate (6.06 g, 18.6 mmol) in DMF (50 mL) was added 2-bromoethyl methyl ether (2.59 g, 1.75 mL, 18.6 mmol). The mixture was heated at 100 C for 3.5 h. After cooling to room temperature, the mixture was poured into water and extracted with ethyl acetate (3x 50 mL).The combined organic layers were washed with brine (50 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (EtOAc/heptanes = 1/4 v/v%) to afford 1- (2-methoxyethyl) -3,5 -dimethyl-4- nitro-pyrazole (2.66 g, 75.4%) as a white crystalline solid.

According to the analysis of related databases, 14531-55-6, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 5775-82-6, name is 4-Bromo-1,3-dimethyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5775-82-6, category: pyrazoles-derivatives

0142-1 2,2′-Azobis(isobutyronitrile) (27 mg) was added to a solution of 4-bromo-1,3-dimethyl-1H-pyrazole (286 mg) and N-bromosuccinimide (320 mg) in chlorobenzene (6 mL), followed by stirring at 80 C. for 7 hours. The reaction mixture was cooled to room temperature, and ethyl acetate and a saturated sodium hydrogen carbonate aqueous solution were added thereto. The organic layer was collected by separation, washed with a saturated sodium chloride aqueous solution, and dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure, thereby obtaining 4-bromo-3-(bromomethyl)-1-methyl-1H-pyrazole (465 mg) as a white solid. MS m/z (M+H): 253.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference of 1572-10-7,Some common heterocyclic compound, 1572-10-7, name is 3-Amino-5-phenylpyrazole, molecular formula is C9H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The general method was described for the synthesis of D1. Compound C1 (150 mg, 0.393 mmol) was dissolved in ethanol (2 mL),followed by addition of 5-phenyl-1H-pyrazol-3-amine (62.63 mg, 0.393 mmol) and triethylamine (119.43 mg, 1.18 mmol). The mixture was stirred at room temperature for 5 h. The resultant mixture was purified by column chromatography to give D1.

The synthetic route of 1572-10-7 has been constantly updated, and we look forward to future research findings.

Application of 68703-67-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 68703-67-3 name is 4-Amino-1H-pyrazole-3-carbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In 500mLIn the eggplant-shaped bottle, add 125mL of distilled water and 50mL of DCM,Add with full agitationSulfur phosgene (2.04mL, 26mmol),Compound 4 (2.63g, 24mmol) was dissolved in 75mL DCM and slowly added to the reaction solution, and stirred at room temperature for 1h after the addition.After the reaction was completed, it was allowed to stand for separation, and the organic phase was successively distilled water.Wash three times with saturated brine, dry with anhydrous sodium sulfate, and filter with suction.The filtrate was concentrated under reduced pressure to obtain 1.78 g of a yellow solid with a yield of 48%. TLC (PE: EA = 2: 1, v / v).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Amino-1H-pyrazole-3-carbonitrile, and friends who are interested can also refer to it.