Category: 68703-67-3

Application of 68703-67-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 68703-67-3 name is 4-Amino-1H-pyrazole-3-carbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In 500mLIn the eggplant-shaped bottle, add 125mL of distilled water and 50mL of DCM,Add with full agitationSulfur phosgene (2.04mL, 26mmol),Compound 4 (2.63g, 24mmol) was dissolved in 75mL DCM and slowly added to the reaction solution, and stirred at room temperature for 1h after the addition.After the reaction was completed, it was allowed to stand for separation, and the organic phase was successively distilled water.Wash three times with saturated brine, dry with anhydrous sodium sulfate, and filter with suction.The filtrate was concentrated under reduced pressure to obtain 1.78 g of a yellow solid with a yield of 48%. TLC (PE: EA = 2: 1, v / v).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Amino-1H-pyrazole-3-carbonitrile, and friends who are interested can also refer to it.

Reference of 68703-67-3,Some common heterocyclic compound, 68703-67-3, name is 4-Amino-1H-pyrazole-3-carbonitrile, molecular formula is C4H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 4-amino-1H-pyrazole-3-carbonitrile (270 mg, 2.4977 mmol) in DMF was added cyclopropane carboxylic acid (1.1 equiv., 2.7475 mmol), HBTU (1.2 equiv., 2.9972 mmol) and DIEA (10 equiv., 24.977 mmol). Upon reaction completion, the reaction was diluted with saturated aqueous sodium bicarbonate and extracted with ethyl acetate. The organic layer was concentrated in vacuo and purified by flash column chromatography onsilica to give 109a. MS-ESI [M+H] = 177.1.

The synthetic route of 68703-67-3 has been constantly updated, and we look forward to future research findings.