Tag: M.W:100-200

Electric Literature of 208511-67-5,Some common heterocyclic compound, 208511-67-5, name is 4-(1H-Pyrazol-3-yl)benzoic acid, molecular formula is C10H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The following compounds were made in a parallel manner using the following procedure: Reauents were weighed into stubby tubes. Stock solutions were made for reagent addition : Dissolved 2305.8 mg Intermediate 4 in 45.75 niL DMF and DIEA(2 eq). Dissolved 3131.85 mg HATU in 75 mE DMF. To each vial containing reagent acid(0.063 mmoi) was added 0.25 ml of the HAT1 solution in DMF followed by DIEA (0.028 mL, 0.158 mrnoi). After stirring for 10 mm, 0.25 ml of the intermediate 4 solution was added and the resulting reaction mixture vials were placed in a Bohdan Miniblock XT and were agitated overnight at 400rpm.Upon completion, reaction mixtures were purified via preparative LC/MS with thefollowing conditions: Column: XBridge C18, 19 x 100 mm, 5-.tm particles; Mobile PhaseA: 5:95 acetonitrile: water with 10 ml?I ammoniumn acetate; Mobile Phase B: c.5:5 acetonitrile: water with 10 m?1 ammonium acetate; Gradient: 10-50% B over 20 minutes, then a 2-minute hold at 100% B; Flow: 20 mL/min. Fractions containing the desired product were combined and dmied via centrifugal evaporation. **Gradient varied for eachreaction depending on polarity of comnpound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(1H-Pyrazol-3-yl)benzoic acid, its application will become more common.

Synthetic Route of 139756-02-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 139756-02-8 as follows.

To a 250 ml three-mouth bottle by adding 2 – ethoxy -3 – pyridine formaldehyde 8.20 g, 1 – methyl -3 – propyl -4 – amino pyrazole -5 – carboxamide 9.6 g and isopropyl alcohol 150 ml, stir at room temperature 3 hours; adding 8.56 g anhydrous ferric trichloride, stirring which separate the reaction system access oxygen, 60 C reaction 3 hours; boil off isopropanol about 100 ml, adding 180 ml purified water, filtered, drying to obtain the solid 15.7 g. Yield: 95.1%.

According to the analysis of related databases, 139756-02-8, the application of this compound in the production field has become more and more popular.

Electric Literature of 26621-44-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 26621-44-3 as follows.

A mixture of 3-nitro-1H-pyrazole (10.0 g, 88.43 mmol), 2,2-dimethyl-oxirane (15.7 mL, 176.9 mmol), potassium carbonate (18.2 g, 132 mmol) and DMF (100 mL) was stirred at 100 C. for 1 h, then stirred overnight at rt. The mixture was then diluted with ethyl acetate and water, the organic layer was separated, dried over Na2SO4, and filtered. The resulting mixture was concentrated under reduced pressure to yield the crude product that was purified (50% EtOAc/heptane) to yield the product 2-methyl-1-(3-nitro-pyrazol-1-yl)-propan-2-ol as a waxy solid (4.88 g, 30%).

According to the analysis of related databases, 26621-44-3, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1572-10-7, name is 3-Amino-5-phenylpyrazole, A new synthetic method of this compound is introduced below., Product Details of 1572-10-7

General procedure: The general method was described for the synthesis of D1. Compound C1 (150 mg, 0.393 mmol) was dissolved in ethanol (2 mL),followed by addition of 5-phenyl-1H-pyrazol-3-amine (62.63 mg, 0.393 mmol) and triethylamine (119.43 mg, 1.18 mmol). The mixture was stirred at room temperature for 5 h. The resultant mixture was purified by column chromatography to give D1.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 25016-17-5, These common heterocyclic compound, 25016-17-5, name is Methyl 5-methyl-1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To 1.2 g of a mixture of acids 8 and 9 obtained in the previous synthesis 5 mL of acetic anhydride was added, the mixture was stirred for 4 hours at boiling and left overnight. The precipitated crystals in the form of fine colorless needles were filtered off and washed with acetic acid. Yield 452 mg (41%), mp 144-145C. The acetic anhydride contained in the mother liquor was hydrolyzed with water. The precipitated crystals were filtered off, washed with water and after drying recrystallized from methanol. Additionally, 101 mg of the reaction product were obtained, total yield 50%. IR spectrum, nu, cm-1: 1730(CO), 1630 (Ph). 1H NMR spectrum, delta, ppm: 2.41 s(3H, CH3), 6.97 s (1H, CH), 7.41 t (1H, Ph, J 7.2 Hz),7.45 t (2H, Ph, J 7.2 Hz), 7.82 d (2H, Ph, J 7.6 Hz),8.50 s (1H,CH). 13 NMR spectrum, delta, ppm: 15.3(CH3), 109.1 (CH), 109.5 (CH), 126.1 (Ph), 128.8,130.6 (Ph), 131.2 (Ph), 131.7 (Ph), 143.6, 152.9, 154.8(CO). Found, %: C 64.98; H 4.48; N 12.40.13H10N2O2. Calculated, %: C 65.02; H 4.46; N 12.38.

Statistics shows that Methyl 5-methyl-1H-pyrazole-3-carboxylate is playing an increasingly important role. we look forward to future research findings about 25016-17-5.

Electric Literature of 16034-46-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16034-46-1 name is 1-Methyl-1H-pyrazole-5-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 1-methyl-1H-pyrazole-5-carboxylic acid (compound 4A, 81 mg, 0.640 mmol), DIEA (286 mg, 2.22 mmol) in CH2Cl2 (10 mL) was added EDCI (189 mg, 0.985 mmol), DMAP (90 mg, 0.739 mmol) at -5 C., then the mixture was stirred at -5 C. for 30 min, (E)-2-methyl-4-(2-methylstyryl)aniline (compound 4, 110 mg, 0.493 mmol) was added, the mixture was stirred at -5 C. for 30 min, warmed to 25 C. and stirred for 11 hrs. TLC (petroleum ether:ethyl acetate=1:1, Rf=0.60) showed starting material consumed completely. The mixture was concentrated in vacuum to give yellow oil. The oil was purified by silica gel column chromatography (petroleum ether:ethyl acetate=100:0 to 60:40) to give (E)-1-methyl-N-(2-methyl-4-(2-methylstyryl)phenyl)-1H-pyrazole-5-carboxamide (compound I-5, 65 mg, 39% yield) as white solid. 1H NMR (400 MHz, DMSO-d6) delta ppm 9.86 (s, 1H), 7.66 (d, J=7.4 Hz, 1H), 7.52-7.58 (m, 2H), 7.49 (d, J=8.2 Hz, 1H), 7.32-7.44 (m, 2H), 7.16-7.23 (m, 3H), 7.05?7.14 (m, 2H), 4.09 (s, 3H), 2.42 (s, 3H), 2.27 (s, 3H); ES-LCMS m/z 332.3 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-pyrazole-5-carboxylic acid, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 956951-01-2, name is 3-Nitro-1H-pyrazole-1-ethanol, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 3-Nitro-1H-pyrazole-1-ethanol

To a stirred solution of compound 95 (4.0 g, 25.477 mmol) in CH2C12 (50 mL) was added triethylamine (8.86 mL, 30.573 mmol) at 0 C and stirred. To this reaction mixture was added methanesulfonyl chloride (2.35 mL, 30.573 mmol) in CH2C12 (5 mL) dropwise over 10 min at 0 C and stirred at the room temperature for 2 h. The reaction was monitored by TLC for complete consumption of compound 95. The reaction mixture was quenched with water (50 mL) and extracted with EtOAc (50 mL x 2). The combined organic layer was washed with brine (50 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 96 (6 g, crude). 1H NMR (400 MHz, DMSO-d6) delta 3.15 (s, 3H), 4.61 (s, 4H), 7.09 (d, J=2.45 Hz, 1H), 8.09 (d, J=2.45 Hz, 1H). LCMS: 236 (M+H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 956951-01-2.

Reference of 956951-01-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 956951-01-2 name is 3-Nitro-1H-pyrazole-1-ethanol, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution 2-(3-nitro-pyrazol-1-yl)-ethanol (3.46 g, 22.02 mmol) in ethanol (40 mL) was placed in a Parr shaker bottle and treated with 10% palladium on carbon (350 mg). The bottle was then put on the Parr shaker and charged with hydrogen to 50 psi and let shake for 1 h. After this time, the reaction mixture was filtered through celite and the celite washed with ethanol. The filtrate was then concentrated in vacuo and azeotroped with acetonitrile and then chloroform to afford 2-(3-amino-pyrazol-1-yl)-ethanol (3.02 g, >quant.) as a light yellow viscous oil: 1H NMR (300 MHz, DMSO-d6 delta ppm 7.26 (d, J=1.83 Hz, 1H), 5.34 (d, J=2.20 Hz, 1H), 4.76 (t, J=5.31 Hz, 1H), 4.50 (s, 2H), 3.78-3.88 (m, 2H), 3.62 (q, J=5.74 Hz, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Nitro-1H-pyrazole-1-ethanol, and friends who are interested can also refer to it.

Synthetic Route of 51985-95-6,Some common heterocyclic compound, 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, molecular formula is C6H8N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 43a) Methyl 5-hydroxy-1 -methyl-1 H-pyrazole-3-carboxylate (2.0 g) was added at 0 ¡ãC to a solution of phosphorus(V) oxychloride (13.7 g) in dry DMF (3 g) and the mixture was heated to 120 ¡ãC for 4 h. After cooling to ambient temperature the reaction was quenched by the addition of ice water (100 mL) and the suspension was stirred for 30 min. The precipitated solid formed was isolated through filtration and was washed with water to yield the desired compound (56percent yield). LC-MS (Method 2): mlz [M+H]+ = 203.2 (MW calc. = 202.60); R, = 2.3 min.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, its application will become more common.

Application of 309740-49-6, A common heterocyclic compound, 309740-49-6, name is Methyl 1-methyl-4-nitro-1H-pyrazole-5-carboxylate, molecular formula is C6H7N3O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1-methyl-4-nitro-1H-pyrazole-5-carboxylate(1.0 g, 5.4 mmol) was dissolved in methanol (30 mL)Palladium on carbon (100 mg),Access to hydrogen,25 C for 3 hours,filter,The filtrate was concentrated in vacuo to give the product(0.8 g, yield: 95.2%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.