Tag: M.W:100-200

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4054-67-5, name is 3,3′,5,5′-Tetramethyl-1H,1’H-4,4′-bipyrazole, This compound has unique chemical properties. The synthetic route is as follows., name: 3,3′,5,5′-Tetramethyl-1H,1’H-4,4′-bipyrazole

General procedure: A mixture of Ag2O (11.6 mg, 0.05 mmol), bpz (19 mg, 0.1 mmol), maleic acid (11.6 mg, 0.1 mmol), 5 mL H2O, and 0.15 mL pyridine was heated to 90 C for 8 h in a 25 mL Teflon-lined reaction vessel, kept at 90 C for 50 h, then slowly cooled to 30 C in 10 h. The pH values of the system were 6.06 and 6.10 before and after the hydrothermal reaction, respectively. Colorless block crystals of 1 were isolated by filtration, washed with H2O, and dried in air.

According to the analysis of related databases, 4054-67-5, the application of this compound in the production field has become more and more popular.

Electric Literature of 103286-54-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 103286-54-0, name is 3-Chloro-1H-pyrazol-4-amine, This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of 5-chloro-1H-pyrazol-4-amine, HCl (2 g, 12.99 mmol) and cesium carbonate (8.89 g, 27.3 mmol) in DMF (13 mL) was added 3,5-difluoropyridine (1.794 g, 15.58 mmol) and the mixture heated at 70 C. for 12 h. The mixture was cooled to room temperature and filtered. The solids were washed with copious amount of ethyl acetate. The filtrates was washed with brine, dried over anhydrous MgSO4 and concentrated in vacuo to give a brown solid. This solid was dissolved in ethyl acetate and the resulting solution was saturated with hexanes to precipitate 3-chloro-1-(5-fluoropyridin-3-yl)-1H-pyrazol-4-amine (2.31 g, 10.32 mmol, 79%) as a brown solid: 1H NMR (400 MHz, DMSO-d6) delta 8.89-8.82 (m, 1H), 8.45 (d, J=2.5 Hz, 1H), 8.07 (d, J=10.4 Hz, 1H), 7.94 (s, 1H), 4.51 (s, 2H); EIMS (m/z) 213 ([M+1]+).

The chemical industry reduces the impact on the environment during synthesis 3-Chloro-1H-pyrazol-4-amine. I believe this compound will play a more active role in future production and life.

Electric Literature of 29097-00-5,Some common heterocyclic compound, 29097-00-5, name is Methyl 3-amino-1H-pyrazole-4-carboxylate, molecular formula is C5H7N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of aminoazole 1c-e (1 mmol), acetoacetamide 2a,b,d (1 mmol), and aromatic aldehyde 3b,d-g (1 mmol) in 10 mL of ethanol was ultrasonicated at room temperature for 90 min in a round-bottom flask equipped with a condenser. The reaction mixture was allowed to stand up to 12 h at room temperature and then was filtered out to give the solid compounds 6a-e, which were washed with ethanol and air dried. Reaction products were obtained in high purity and did not require further purification by recrystallization.

The synthetic route of 29097-00-5 has been constantly updated, and we look forward to future research findings.

Application of 41680-34-6,Some common heterocyclic compound, 41680-34-6, name is 3-Amino-1H-pyrazole-4-carboxylic acid, molecular formula is C4H5N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a cooled (0 C.) solution of 3-diethoxymethyl-2-ethoxy-tetrahydro-furan (prepared accordingly to WO2005/095317) (350 mg, 1.61 mmol) in dichloromethane (2 mL) was added an aqueous solution of hydrochloric acid (6 M, 2 mL) followed by 5-amino-1H-pyrazole-4-carboxylic acid (250 mg, 1.97 mmol) and the resulting mixture was gradually heated at 70 C. for 1 hour. The organic solvent evaporated while heating and the solid formed was collected by filtration of the aqueous layer to give 50 mg of 5-amino-1H-pyrazole-4-carboxylic acid residual. The filtrate was repeatedly triturated with diethyl ether, decanted and lyophilized to give 6-(2-hydroxy-ethyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid.

The synthetic route of 41680-34-6 has been constantly updated, and we look forward to future research findings.

Application of 60061-60-1, The chemical industry reduces the impact on the environment during synthesis 60061-60-1, name is 4-Bromo-3-isopropyl-1H-pyrazole, I believe this compound will play a more active role in future production and life.

Part B – 4-Bromo-3-isopropyl-N,N,alpha-trimethylpyrazole-1-acetamide Sodium hydride (2.4 g., 0.06 mole) (57% oily dispersion) was washed with dry toluene (50 ml.) and then suspended in dry toluene (50 ml.). 4-Bromo-3-isopropylpyrazole (5.7 g., 0.03 mole) in toluene (10 ml.) was added drop by drop to the sodium hydride suspension, the mixture heated to reflux, and then treated dropwise with a solution of 2-chloro-N,N-dimethylpropionamide (8.1 g., 0.06 mole). Heating was continued for 4 hours, the mixture cooled, and treated with toluene (60 ml.) and water (40 ml.). The toluene layer was washed with water, (2 * 60 ml.), dried (magnesium sulfate) and the solvent removed under reduced pressure. The resulting oil was distilled to yield 4-bromo-3-isopropyl-N,N,alpha-trimethylpyrazole-1-acetamide (5.7 g., 67%) with a boiling point of 99 to 101 C. at 0.03 mm Hg. On standing, the oil solidified to give crystals having a melting point at 63 to 65 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3-isopropyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Related Products of 5071-61-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5071-61-4, name is 5-Phenyl-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.

A solution of acid 4 (0.09 g, 0.47 mmol) in dry DMF (2 mL) treated sequentially with amine (5a-i, 6a-e and 7a-h; 0.517 mmol)and triethylamine (0.94 mmol) was stirred under a N2 atmosphere for 15 min, later TBTU (0.56 mmol) was added and reaction mixture refluxed for 4-10 h. The reaction mixture was quenched with aq satd NH4Cl solution (10 mL). After 10 min, it was diluted withCHCl3 (2 10 mL) and washed with water (10 mL), NaHCO3 solution(10 mL) and brine (10 mL). The organic layers were dried over anhydrous sodium sulfate, evaporated and the residue purified by column chromatography using 30% ethyl acetate in pet. ether to afford corresponding amides 8a-i, 9a-e and 10a-h.

The chemical industry reduces the impact on the environment during synthesis 5-Phenyl-1H-pyrazole-3-carboxylic acid. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1369959-12-5, name is 3-Chloro-5-nitro-1H-pyrazole, A new synthetic method of this compound is introduced below., name: 3-Chloro-5-nitro-1H-pyrazole

Aqueous HCI (16.8 mL, 544 mmol) was added over a period of 10 min to a solution of compound 1-1 b (4.0 g, 27.1 mmol) in MeOH (200 mL). The reaction mixture was cooled to 0 C and tin(ll) chloride (30.0 g, 158 mmol) was added portion wise and the resulting reaction mixture was stirred at rt. The progress of the reaction was monitored by TLC and after 16 h, when starting material was deemed consumed, the solvent was evaporated. The residue was diluted with EtOAc (100 mL) and 30% aqueous NaOH solution (120 mL) was added dropwise at 0 C until basic pH, then stirred at 0 C for 2h. Solid precipitates were filtered off through a pad of Celite and the cake was rinsed with EtOAc (50 mL) and water (50 mL). The organic phase was separated and the aqueous phase was extracted with EtOAc (50 mL). The combined organic layers were washed with brine (50 mL), dried (Na2S04), filtered and concentrated under vacuum which gave the title compound (3.5 g, 93 %). The compound was used in next step without further purification. MS (ES+) 1 18.04 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 4149-06-8, name is 3-Amino-1-phenyl-1H-pyrazol-5(4H)-one, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4149-06-8, Computed Properties of C9H9N3O

General procedure: The mixture of isatin (1 mmol), 3-amino-1-phenyl-1H-pyrazol-5(4H)-one (1 mmol), 1,2-diarylethan-1-one, 2,3-dihydroinden-1-one (1 mmol) or 3,4-dihydronaphthalen-1(2H)-one (1 mmol), H2O (6 mL), HOAc (2 mL) was put in a reaction flask under 90 C about 5-7 h (monitored by TLC). After completion, the reaction mixture was cooled to room temperature and the products would be isolated out at same time. Then, compound 4 was recrystallized from DMF, however, the pure products of 6 and 8 were filtered from water, dried, without further recrystallization.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Amino-1-phenyl-1H-pyrazol-5(4H)-one, and friends who are interested can also refer to it.

Synthetic Route of 23170-45-8,Some common heterocyclic compound, 23170-45-8, name is Methyl 3-methyl-1H-pyrazole-4-carboxylate, molecular formula is C6H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Compound (3a-e) (1.2mmol), CuI (19.1mg, 0.1mmol), trans-N, N?-dimethyl-1, 2-cyclohexane-diamine (29mg, 0.2mmol), K2CO3 (0.29g, 2.1mmol) and DMF (3mL) were added to a tube filled with argon. The mixture was stirred at 110C for 24h, diluted with H2O (20mL), and extracted with EtOAc (15mL×2). The combined organic phases were washed with H2O (20mL×2) and brine (30mL), dried over MgSO4 and concentrated in a vacuum. The residue was purified by flash column chromatography (12-25% EtOAc in petroleum ether).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 3-methyl-1H-pyrazole-4-carboxylate, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3524-32-1, name is 5-Amino-1,3-dimethylpyrazole, A new synthetic method of this compound is introduced below., COA of Formula: C5H9N3

General procedure: A solution of equimolar amounts (4.5 mmol) of 1,3-dimethyl-1H-pyrazol-5-amine 3 [18] and substituted phenylisocyanates 4a-g in THF (12 mL) was stirred at room temperature for 24 h. The solid residue was filtered, washed with 1 mL of ethyl acetate, and then crystallized from a suitable solvent.

The synthetic route of 3524-32-1 has been constantly updated, and we look forward to future research findings.