Application of 60061-60-1, The chemical industry reduces the impact on the environment during synthesis 60061-60-1, name is 4-Bromo-3-isopropyl-1H-pyrazole, I believe this compound will play a more active role in future production and life.
Part B – 4-Bromo-3-isopropyl-N,N,alpha-trimethylpyrazole-1-acetamide Sodium hydride (2.4 g., 0.06 mole) (57% oily dispersion) was washed with dry toluene (50 ml.) and then suspended in dry toluene (50 ml.). 4-Bromo-3-isopropylpyrazole (5.7 g., 0.03 mole) in toluene (10 ml.) was added drop by drop to the sodium hydride suspension, the mixture heated to reflux, and then treated dropwise with a solution of 2-chloro-N,N-dimethylpropionamide (8.1 g., 0.06 mole). Heating was continued for 4 hours, the mixture cooled, and treated with toluene (60 ml.) and water (40 ml.). The toluene layer was washed with water, (2 * 60 ml.), dried (magnesium sulfate) and the solvent removed under reduced pressure. The resulting oil was distilled to yield 4-bromo-3-isopropyl-N,N,alpha-trimethylpyrazole-1-acetamide (5.7 g., 67%) with a boiling point of 99 to 101 C. at 0.03 mm Hg. On standing, the oil solidified to give crystals having a melting point at 63 to 65 C.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3-isopropyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.