Tag: M.W=0-100

Adding a certain compound to certain chemical reactions, such as: 35277-02-2, name is 4-Fluoro-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35277-02-2, name: 4-Fluoro-1H-pyrazole

Step 1: 5-(4-fluoro-1H-pyrazol-1-yl)pyrazine-2-carbonitrile To a solution of 5-chloropyrazine-2-carbonitrile (280 mg, 2.0 mmol) in DMF was added 4-fluoro-1H-pyrazole (170 mg, 2.0 mmol), and potassium acetate (395 mg, 4.0 mmol). The mixture was stirred at the 100 C. for 4 hours. The reaction mixture was cooled to 20 C., poured into brine (25 mL), and extracted with ethyl acetate. The organic layer was dried over sodium sulfate, concentrated and purified by column chromatography (hexane:ethyl acetate=5:1) to give 5-(4-fluoro-1H-pyrazol-1-yl)pyrazin-2-carbonitrile (310 mg, Yield 82%). The structure was confirmed by LC-MS.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Fluoro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Electric Literature of 1904-31-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows.

Under the protection of nitrogen,The compound 1-methyl-1H-pyrazol-3-amine (200 mg, 2.06 mmol) was suspended in THF (5 mL).Then, CuI (431 mg, 2.27 mmol) and CH2I2 (0.5 mL, 6.18 mmol) were added thereto.Next addNitrosoisoamyl ester(8.30 mL, 61.78 mmol).The mixture was heated to reflux for 5 hours and then cooled to room temperature.Then diluted with EtOAc (15 mL).The resulting mixture was washed with aq. aq.Filtered through a silica gel pad,The filtrate was washed with saturated brine (10 mL).The organic phase was dried over anhydrous sodium sulfate and then evaporated.The residue was chromatographed on silica gel (EtOAc /EtOAcThe title compound was obtained as a yellow liquid (233 mg, 54.4%).

The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-pyrazol-3-amine. I believe this compound will play a more active role in future production and life.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35277-02-2 as follows. SDS of cas: 35277-02-2

Step 1 : Benzyl 1-(4-fluoro-1 H-pyrazol-1 -yl)cyclopropanecarboxylate To a solution of 4-fluoropyrazole (125 mg, 1.45 mmol) in tetrahydrofuran (4 mL) at 0C was added sodium hydride (60% suspension in mineral oil, 1 16 mg, 2.90 mmol). The mixture was stirred at 0C for 40 min before benzyl 2,4-dibromobutyrate (0.30 mL, 1.50 mmol) was added dropwise. The reaction mixture was stirred at room temperature for 18 h. The reaction mixture was diluted with ethyl acetate and washed with water and brine. The organics were dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified via flash chromatography to afford benzyl 1-(4-fluoro-1 /-/-pyrazol-1-yl)cyclopropanecarboxylate as a clear oil (1 15 mg, 30.4%). 1H NMR (400 MHz, CDCI3) delta 1.64-1.70 (m, 2H), 1.81 -1.86 (m, 2H), 5.14 (s, 2H), 7.22-7.26 (m, 2H), 7.31-7.36 (m, 3H), 7.40 (td, 2H).

According to the analysis of related databases, 35277-02-2, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 288-13-1, name is 1H-Pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 288-13-1, COA of Formula: C3H4N2

4-Iodopyrazole (20) A flask equipped with a nitrogen inlet, an addition funnel, a thermowell, and a mechanical stirrer was charged with pyrazole (1, 450 g, 6.62 mol) and tetrahydrofuran (THF, 5 L) at ambient temperature. The mixture was then cooled to 10 C. and N-iodosuccinimide (NIS, 1490 g, 6.62 mol, 1.0 equiv) was added to the mixture in portions as a solid at approximately 10 C. The resulting reaction mixture was then stirred at ambient temperature for 1 hour (longer reaction times may be necessary depending on ambient temperature). The mixture was then filtered and the THF was removed under reduced pressure. The residue was suspended in ethyl acetate (6 L) and insoluble materials were filtered. The dark filtrate was sequentially washed with saturated aqueous sodium thiosulfate solution (2*3 L) (organic layer lightens to a pale yellow), water (2*3 L), and brine (2 L). The resulting organic layer was then dried over sodium sulfate, filtered, and concentrated under reduced pressure to afford 4-iodopyrazole (1138 g, 1284.1 g theoretical, 88.6%) as a white to pale yellow solid after being dried in a vacuum oven at approximately 30 C. overnight. 1H NMR (400 MHz, DMSO-d6) delta 13.17 (bs, 1H), 7.93 (bs, 1H), 7.55 (bs, 1H) ppm; C3H31N2 (MW, 193.97), LCMS (EI) m/e 195 (M++H).

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Application of 28466-26-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 28466-26-4 name is 4-Aminopyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

As shown in step 6-iii of Scheme 6, lH-pyrazol-4-amine (149 mg, 1.79 mmol), methyl 2-(bromomethyl)-4-(5,6-dimethoxy-3-pyridyl)-6-methyl-benzoate (680 mg, 1.79 mmol) and DIEA (231 mg, 312 mu^, 1.79 mmol) were combined in DMF (5 mL), heated to 90C for 6 hours, and allowed to cool to room temperature over 16 hours. The reaction mixture was taken up in EtO Ac/water and the organic layer washed with water, brine, dried, and concentrated under reduced pressure to yield a foam. The foam was recrystallized in DCM/MeOH. The resulting solid was collected by filtration, washed with DCM, and dried under vacuum to provide 5-(5,6-dimethoxy-3-pyridyl)-7-methyl-2-(lH-pyrazol-4- yl)isoindolin-l-one (Compound 2024, 115 mg). The filtrate from the recrystallization was concentrated under reduced pressure and the residue purified by silica gel chromatography (20 to 100% EtO Ac/hex) to yield an additional 88 mg of Compound 2024 (total yield 203 mg, 0.66 mmol, 32% yield): ESMS (Mu+Eta) 351.26; 1H NMR (DMSO-d6) delta 12.83 (s, 1Eta), 8.10 (m, 2Eta), 7.88 (s, 1Eta), 7.74 (s, 1Eta), 7.61 (s, 2Eta), 4.83 (s, 2Eta), 3.92 (s, 3Eta), 3.91 (s, 3Eta), 2.72 (s, 3Eta).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Aminopyrazole, and friends who are interested can also refer to it.

Related Products of 113402-89-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 113402-89-4 as follows.

Will 10mmol compound 1,10 mmol of compound 2 and 1 mmol of K2CO3 and 10 mL of PEG 400 were added to the reaction flask.Reaction at 80 ° C for 24 h,The reaction solution was cooled to room temperature.Precipitating in ether,The filtrate was collected by filtration.Purified by gel chromatography (mobile phase petroleum ether / ethyl acetate = 5:1),Compound 3;Compound 3 (1 mmol),Raney Nickel (0.1g),Sodium n-propoxide (0.92 g, 11 mmol) was dissolved in 50 mL of 1,2-dimethoxyethane.Reaction at 60 ° C for 10 h,Cool to room temperature,Collect organic phase by filtration,Removal of 1,2-dimethoxyethane by rotary evaporation,The compound 62 was purified by column chromatography using acetonitrile / dichloromethane (5:1 by volume).

According to the analysis of related databases, 113402-89-4, the application of this compound in the production field has become more and more popular.

Reference of 31108-57-3, These common heterocyclic compound, 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of 4-cyano-lH-pyrazole (315 mg, 3.39 mmol) in THF (3 mL) was added portionwise NaH (406 mg, 10.17 mmol, 60% in mineral oil) at 0C under N2. The mixture was stirred at 0C for 30 min, then intermediate 8 (1.6 g, 5.08 mmol) in THF (6 mL) was added to the mixture. The mixture was stirred at rt for 2 h. The mixture was dried under N2 and washed with i-PrOH and MTBE. The crude product was purified by recrystallization from i-PrOH (5 mL) to give the title compound (0.50 g, 24 %) as a white solid. LCMS [M-H]- 370.1 1H NMR (400 MHz, CD3OD) delta 8.61 (s, 1H), 8.11 (s, 1H), 7.95 (d, J = 6.4 Hz, 1H), 6.88 (s, 1H), 2.80-2.86 (m, 4H), 2.70-2.73 (m, 4H), 1.95-2.07 (m, 4H).

The synthetic route of 31108-57-3 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1192-21-8, name is 1-Methyl-1H-pyrazol-5-amine, This compound has unique chemical properties. The synthetic route is as follows., category: pyrazoles-derivatives

General procedure B for the synthesis of the final product lb from intermediate E or K In a sealed tube, the bromo-intermediate E or K (0.08 mmole), t-BuONa (0.16 mmole) and the amine (0.16 mmole) were charged. The tube was filled with Argon, dry toluene (1.0 ml) was added and the mixture was stirred for 2 min. Then Pd2(dba)3 (0.0024 mmole) and t-BuXphos (0.016 mmole) were added and the vial was flushed with Argon and stirred for 2 min. The reaction mixture was then heated at 100 °C for 18h. The mixture was concentrated in vacuo and purified by flash chromatography eluting with ethyl acetate/n-heptane. To a solution of the purified product in dichloromethane (0.5ml) was added TFA (0.4 mmole) and the mixture was stirred at room temperature for 30 min. The mixture was diluted with dichloromethane and the organic layer was washed with saturated aqueous NaHC03, dried and evaporated. The crude material was purified by chromatography on NH2-silica using dichloromethane to give the pure final product lb. In case of using intermediate E, the coupling product was deprotected using CF3COOH as described above to give the pure final product lb.Example 36(S)-2-Amino-6-[2-fluoro-5-(2-methyl-2H-pyrazol-3-ylamino)-phenyl]-3,5,5,6-tetramethyl- 5,6-dihydro-3H-pyrimidin-4-oneThe coupling of [(S)-4-(5-bromo-2-fluoro-phenyl)- 1,4,5, 5-tetramethyl-6-oxo- 1,4,5, 6- tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester (intermediate E8) and 2-methyl-2H- pyrazol-3-ylamine according to procedure B followed by deprotection yielded the title compound as a pale brown waxy solid. MS (ESI): m/z = 359.2 [M+H]+.

According to the analysis of related databases, 1192-21-8, the application of this compound in the production field has become more and more popular.

Related Products of 35344-95-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Preparation 52: l-(2-Hydroxy-ethyl)-lH-pyrazole-4-carbaldehyde Combine lH-pyrazole-4-carbaldehyde (0.110 g, 1.14 mmol), 2-bromoethanol(0.172 g, 1.37 mmol), and potassium carbonate (0.236 g, 1.71 mmol) in acetonitrile (2 mL). Heat in microwave at 150 0C for 20 min.. Cool to room temperature and filter, washing with acetonitrile. Concentrate filtrate to give the title preparation (0.155 g, 97percent). GC-MS: m/z = 140 [M+].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Pyrazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Application of 2817-71-2, A common heterocyclic compound, 2817-71-2, name is 1-Ethylpyrazole, molecular formula is C5H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3.102 g (18 mmol) of hydrobromic acid was gradually added dropwise to 1.44 g (15 mmol) of 1-ethylpyrazole,The reaction was stirred at 40 ~ 50 for 15 ~ 25h to ensure that all the substrates reacted completely, then cyclohexane was used as a water-carrying agent to remove the moisture therein,Further washing with ethyl acetate gave 1-ethylpyrazole hydrobromide as a pale yellow liquid (yield> 90%).

The synthetic route of 2817-71-2 has been constantly updated, and we look forward to future research findings.