Application of 28466-26-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 28466-26-4 name is 4-Aminopyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
As shown in step 6-iii of Scheme 6, lH-pyrazol-4-amine (149 mg, 1.79 mmol), methyl 2-(bromomethyl)-4-(5,6-dimethoxy-3-pyridyl)-6-methyl-benzoate (680 mg, 1.79 mmol) and DIEA (231 mg, 312 mu^, 1.79 mmol) were combined in DMF (5 mL), heated to 90C for 6 hours, and allowed to cool to room temperature over 16 hours. The reaction mixture was taken up in EtO Ac/water and the organic layer washed with water, brine, dried, and concentrated under reduced pressure to yield a foam. The foam was recrystallized in DCM/MeOH. The resulting solid was collected by filtration, washed with DCM, and dried under vacuum to provide 5-(5,6-dimethoxy-3-pyridyl)-7-methyl-2-(lH-pyrazol-4- yl)isoindolin-l-one (Compound 2024, 115 mg). The filtrate from the recrystallization was concentrated under reduced pressure and the residue purified by silica gel chromatography (20 to 100% EtO Ac/hex) to yield an additional 88 mg of Compound 2024 (total yield 203 mg, 0.66 mmol, 32% yield): ESMS (Mu+Eta) 351.26; 1H NMR (DMSO-d6) delta 12.83 (s, 1Eta), 8.10 (m, 2Eta), 7.88 (s, 1Eta), 7.74 (s, 1Eta), 7.61 (s, 2Eta), 4.83 (s, 2Eta), 3.92 (s, 3Eta), 3.91 (s, 3Eta), 2.72 (s, 3Eta).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Aminopyrazole, and friends who are interested can also refer to it.