pyrazoles-derivatives

In 2015,Roche, Maxime; Salim, Salim Mmadi.; Bignon, Jerome; Levaique, Helene; Brion, Jean-Daniel; Alami, Mouad; Hamze, Abdallah published 《Palladium-Catalyzed One-Pot Reaction of Hydrazones, Dihaloarenes, and Organoboron Reagents: Synthesis and Cytotoxic Activity of 1,1-Diarylethylene Derivatives》.Journal of Organic Chemistry published the findings.Category: pyrazoles-derivatives The information in the text is summarized as follows:

A new three-component assembly reaction between N-tosylhydrazones, dihalogenated arenes, and boronic acids or boronate esters was developed, producing highly substituted 1,1-diarylethylenes in good yields. The two C-C bonds formed through this coupling have been catalyzed by a single Pd-catalyst in a one-pot fashion. It is noted that the one-pot pinacol boronate cross-coupling reaction generally provides products in high yields, offers an expansive substrate scope, and can address a broad range of aryl, styrene, vinyl, and heterocyclic olefinic targets. Thus, e.g., the combination of Pd(OAc)2/SPhos and LiO-tBu in CPME catalyzed the first migratory insertion step of 4-methylacetophenone tosylhydrazone with 1-chloro-4-iodobenzene; PhB(OH)2, K3PO4.H2O and water were subsequently added for the second step to afford I (84%, optimized). The scope of this one-pot coupling has been also extended to the synthesis of the 1,1-diarylethylene skeleton of the natural product ratanhine. The new compounds were evaluated for their cytotoxic activity, and this allowed the identification of compound II that exhibits excellent antiproliferative activity in the nanomolar concentration range against HCT116 cancer cell lines. After reading the article, we found that the author used 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0Category: pyrazoles-derivatives)

1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, monoamine oxidase inhibitory, anti-inflammatory, antidiabetic and antibacterial activities. Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2016,Zhao, Fei; Zhang, Jing; Zhang, Leduo; Hao, Yu; Shi, Chen; Xia, Guangxin; Yu, Jianxin; Liu, Yanjun published 《Discovery and optimization of a series of imidazo[4,5-b]pyrazine derivatives as highly potent and exquisitely selective inhibitors of the mesenchymal-epithelial transition factor (c-Met) protein kinase》.Bioorganic & Medicinal Chemistry published the findings.Application In Synthesis of 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole The information in the text is summarized as follows:

Aberrant c-Met activation has been implicated in multiple tumor oncogenic processes and drug resistance. In this study, a series of imidazo[4,5-b]pyrazine derivatives was designed and synthesized, and their inhibitory activities were evaluated in vitro. Structure-activity relationship (SAR) was investigated systematically and docking anal. was performed to elucidate the binding mode, leading to the identification of the most promising compound 1D-2 (I) which exhibited significant inhibitory effect on both enzymic (IC50 = 1.45 nM) and cellular (IC50 = 24.7 nM in H1993 cell line) assays, as well as exquisite selectivity and satisfactory metabolic stability in human and rat liver microsomes. In addition to this study using 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, there are many other studies that have used 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0Application In Synthesis of 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole) was used in this study.

1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 847818-74-0) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, monoamine oxidase inhibitory, anti-inflammatory, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, antidiabetic and antibacterial activities. Application In Synthesis of 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2016,Sun, Liyuan; Morales-Collazo, Oscar; Xia, Han; Brennecke, Joan F. published 《Effect of Structure on Transport Properties (Viscosity, Ionic Conductivity, and Self-Diffusion Coefficient) of Aprotic Heterocyclic Anion (AHA) Room Temperature Ionic Liquids. 2. Variation of Alkyl Chain Length in the Phosphonium Cation》.Journal of Physical Chemistry B published the findings.Synthetic Route of C4H3F3N2 The information in the text is summarized as follows:

A series of room-temperature ionic liquids (ILs) composed of triethyl(alkyl)phosphonium cations paired with three different aprotic heterocyclic anions (AHAs) (alkyl = Bu ([P2224]+) and octyl ([P2228]+)) were prepared to investigate the effect of cationic alkyl chain length on transport properties. The transport properties and d. of these ILs were measured from 283.15 to 343.15 K at ambient pressure. The dependence of the transport properties (viscosity, ionic conductivity, diffusivity, and molar conductivity) on temperature can be described by the Vogel-Fulcher-Tamman (VFT) equation. The ratio of the molar conductivity obtained from the molar concentration and ionic conductivity measurements to that calculated from self-diffusion coefficients (measured by pulsed gradient spin-echo NMR spectroscopy) using the Nernst-Einstein equation was used to quantify the ionicity of these ILs. The molar conductivity ratio decreases with increasing number of carbon atoms in the alkyl chain, indicating that the reduced Coulombic interactions resulting from lower d. are more than balanced by the increased van der Waals interactions between the alkyl chains. The results of this study may provide insight into the design of ILs with enhanced dynamics that may be suitable as electrolytes in lithium ion batteries and other electrochem. applications. The results came from multiple reactions, including the reaction of 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Synthetic Route of C4H3F3N2)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Synthetic Route of C4H3F3N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Che, Jinxin; Dai, Xiaoyang; Gao, Jian; Sheng, Haichao; Zhan, Wenhu; Lu, Yang; Li, Dan; Gao, Zizheng; Jin, Zegao; Chen, Binhui; Luo, Peihua; Yang, Bo; Hu, Yongzhou; He, Qiaojun; Weng, Qinjie; Dong, Xiaowu published their research in Journal of Medicinal Chemistry in 2021. The article was titled 《Discovery of N-((3S,4S)-4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl-1H-pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity》.Electric Literature of C9H15BN2O2 The article contains the following contents:

Here, the inhibition of Akt2 isoenzyme might be a driver for keratinocyte apoptosis was demonstrate, which promotes us to search for new selective Akt inhibitor compounds I [R1 = 4-F, 3,4-di-F, 3,5-di-F; R2 = 2-F, 3-F, 2-Cl, 2,6-di-F, 2,5-di-F, 2-F-6-Cl; R3 = H, Cl, Br; R4 = H, Me, Et] with an improved cutaneous safety property. According to our previous research, compound I [R1 = 3,4-di-F; R2 = R3 = H; R4 = Me] was selected for further optimization for overcoming the disadvantages of compound II, including high Akt2 inhibition and high toxicity against HaCaT keratinocytes. The dihedral angle-based design and mol. dynamics simulation led to the identification of Hu7691 I [R1 = 3,4-di-F; R2 = 2-F; R3 = H; R4 = Me] that achieves a 24-fold selectivity between Akt1 and Akt2. Hu7691 I [R1 = 3,4-di-F; R2 = 2-F; R3 = H; R4 = Me] exhibited low activity in inducing HaCaT apoptosis, promising kinase selectivity, and excellent anticancer cell proliferation potencies. Based on the superior results of safety property, pharmacokinetic profile, and in vivo efficacy, the National Medical Products Administration (NMPA) approved the investigational new drug (IND) application of Hu7691 I [R1 = 3,4-di-F; R2 = 2-F; R3 = H; R4 = Me]. In the part of experimental materials, we found many familiar compounds, such as 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 844501-71-9Electric Literature of C9H15BN2O2)

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 844501-71-9) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities. Electric Literature of C9H15BN2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 20154-03-4In 2017 ,《Antimicrobial activities of pyridinium-tailored pyrazoles bearing 1,3,4-oxadiazole scaffolds》 appeared in Journal of Saudi Chemical Society. The author of the article were Zhou, Lei; Wang, Pei-Yi; Zhou, Jian; Shao, Wu-Bin; Fang, He-Shu; Wu, Zhi-Bing; Yang, Song. The article conveys some information:

Herein, a series of pyridinium-tailored 5-trifluoromethylpyrazoles containing 1,3,4-oxadiazole moieties were constructed through coupling key pharmaceutical fragments of pyridinium, pyrazole, and 1,3,4-oxadiazole scaffolds in single mol. architecture. Antimicrobial results suggested that this kind of compounds exhibited significant activities against three types of pathogenic bacteria and six fungal strains in vitro. The minimal EC50 values of designed compounds against Xanthomonas oryzae pv. oryzae, Ralstonia solanacearum, and Xanthomonas axonopodis pv. citri could reach to 0.467, 1.04, and 0.600μg/mL, resp., through tuning and optimizing N-substituents, bridging atom, and alkyl length of the tailor. Antifungal assays revealed that all title mols. possessed considerable activity against Botrytis cinerea with the minimal EC50 value up to 2.71μg/mL; and compounds I-8, I-10, I-12, II-12, and IV-12 showed the strongest growth suppression toward Rhizoctonia solani with EC50 values ranging from 10.2 to 24.0μg/mL. Given the above results, this kind of compounds could serve as new lead compounds in the research of antimicrobial chemotherapy. The results came from multiple reactions, including the reaction of 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Related Products of 20154-03-4)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Related Products of 20154-03-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleIn 2015 ,《Discovery of potent and selective urea-based ROCK inhibitors: Exploring the inhibitor’s potency and ROCK2/PKA selectivity by 3D-QSAR, molecular docking and molecular dynamics simulations》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Mei, Ding; Yin, Yan; Wu, Fanhong; Cui, Jiaxing; Zhou, Hong; Sun, Guofeng; Jiang, Yu; Feng, Yangbo. The article conveys some information:

An activity model and a selectivity model from 3D-QSAR studies were established by CoMFA and CoMSIA to explore the SAR. Then docking was used to study the binding modes between ligand and kinases (ROCK2 and PKA), and the mol. docking results were further validated by MD simulations. Computational results suggested that substitution containing pos. charge attached to the middle Ph ring, or electropos. group in urea linker was favored for both activity and ROCK2/PKA selectivity. Finally, three compounds were designed, and biol. evaluation demonstrated that these mol. models were effective for guiding the design of potent and selective ROCK inhibitors. The results came from multiple reactions, including the reaction of 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 844501-71-9Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole)

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(cas: 844501-71-9) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities. Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Quality Control of 1-MethylpyrazoleOn May 1, 2022 ,《Phosphine-free ruthenium complexes supported by a pincer ligand bearing 1,2-dihydropyrimidine for Oppenauer-type oxidation of secondary alcohols》 appeared in Journal of Organometallic Chemistry. The author of the article were Zhou, Jun; Luo, Shubiao; Liu, Hongming; Xue, Peng. The article conveys some information:

Treatment of the (diethylaminomethyl-picolyl)pyrazolium (A3) with NaOH in dichloromethane affords the pincer ligand (L) bearing a 1,2-dihydropyrimidine unit. Reaction of [RuCl2(DMSO)4] and the ligand (L) affords the complex [RuCl2(L)(DMSO)] (Ru1). Removal of the chlorides from Ru1 with either NaBF4 or KPF6 in CH3CN produces the complexes [Ru(L)(CH3CN)3](BF4)2 (Ru2) and [Ru(L)(CH3CN)3](PF6)2 (Ru3), resp. Ru2 has been characterized with X-ray crystallog. All of the new ruthenium complexes (Ru1-Ru3) are catalytically active in the Oppenauer-type oxidation of secondary alcs. Among them, the complex Ru1 is the most active. Steric effects were observed from the outcome of substituted acetophenones. The experimental part of the paper was very detailed, including the reaction process of 1-Methylpyrazole(cas: 930-36-9Quality Control of 1-Methylpyrazole)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Quality Control of 1-Methylpyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 1972,Acta Pharmaceutica Suecica included an article by Carlson, Lars A.; Hedbom, Christina; Helgstrand, Erik; Sjoberg, Berndt; Stjernstrom, Nils E.. Synthetic Route of C5H8N2O. The article was titled 《Potential hypolipidemic agents. III. Heterocyclic compounds affecting free fatty acid mobilization in vivo》. The information in the text is summarized as follows:

Compounds such as 3-methyl-5-isoxazolecarboxylic acid [4857-42-5], 5-fluoronicotinic acid [402-66-4], 5-fluoro-3-pyridylacetic acid [38129-24-7], and 3-methylpyrazole [1453-58-3] exhibited the highest inhibition of free fatty acid mobilization in blood among 188 heterocyclic compounds tested in dogs, while compounds such as 5-methyl-3-isoxazolecarboxylic acid [3405-77-4], 2-fluoronicotinic acid [393-55-5], and 3-aminobenzoic acid [99-05-8] had no effect on free fatty acid mobilization. In the experiment, the researchers used (3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7Synthetic Route of C5H8N2O)

(3-methyl-1H-pyrazol-5-yl)methanol(cas: 29004-73-7) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Synthetic Route of C5H8N2O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2011,Organic & Biomolecular Chemistry included an article by Koos, Peter; Gross, Ulrike; Polyzos, Anastasios; O’Brien, Matthew; Baxendale, Ian; Ley, Steven V.. Related Products of 5952-93-2. The article was titled 《Teflon AF-2400 mediated gas-liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration》. The information in the text is summarized as follows:

We report on the development of a continuous flow process for the palladium catalyzed methoxycarbonylation of aryl, heteroaromatic and vinyl iodides and an aryl bromide using a Teflon AF-2400 based Tube-in-Tube reactor to mediate the selective permeation of carbon monoxide into solution at elevated pressures. The low volume of pressurized gas within the reactor (5.6 mL) offers the potential for an enhanced safety profile compared to batch processes. We also present preliminary results for the use of in situ FTIR to measure solution concentrations of carbon monoxide and demonstrate the use of a second reactor to effect the removal of carbon monoxide from the flow stream. After reading the article, we found that the author used Methyl 1-methyl-1H-pyrazole-4-carboxylate(cas: 5952-93-2Related Products of 5952-93-2)

Methyl 1-methyl-1H-pyrazole-4-carboxylate(cas: 5952-93-2) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Related Products of 5952-93-2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Sun, Xiaohua; Feng, Lijun; Sun, Chuance; Kang, Congmin published their research in Pharmaceutical Chemistry Journal on December 31 ,2021. The article was titled 《Synthesis of Quinoxaline Derivatives as Intermediates to Obtain Erdafitinib》.Related Products of 930-36-9 The article contains the following contents:

In this work, quinoxaline derivative 7-bromo-2-(1-methyl-1H-pyrazol-4-yl)quinoxaline, which is an essential intermediate to obtain drug erdafitinib, has been synthesized in reasonably good yield using 4-bromobenzene-1,2-diamine and 2-bromo-1-(1-methyl-1H-pyrazol-4-yl)ethan-1-one as raw materials, triethylene diamine (DABCO) as catalyst, and THF as solvent. To the best of authors’ knowledge, this is the first time 7-bromo-2-(1-methyl-1H-pyrazol-4-yl)quinoxaline has been acquired by the proposed method. In the experiment, the researchers used 1-Methylpyrazole(cas: 930-36-9Related Products of 930-36-9)

1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Related Products of 930-36-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics