In 2011,Organic & Biomolecular Chemistry included an article by Koos, Peter; Gross, Ulrike; Polyzos, Anastasios; O’Brien, Matthew; Baxendale, Ian; Ley, Steven V.. Related Products of 5952-93-2. The article was titled 《Teflon AF-2400 mediated gas-liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration》. The information in the text is summarized as follows:
We report on the development of a continuous flow process for the palladium catalyzed methoxycarbonylation of aryl, heteroaromatic and vinyl iodides and an aryl bromide using a Teflon AF-2400 based Tube-in-Tube reactor to mediate the selective permeation of carbon monoxide into solution at elevated pressures. The low volume of pressurized gas within the reactor (5.6 mL) offers the potential for an enhanced safety profile compared to batch processes. We also present preliminary results for the use of in situ FTIR to measure solution concentrations of carbon monoxide and demonstrate the use of a second reactor to effect the removal of carbon monoxide from the flow stream. After reading the article, we found that the author used Methyl 1-methyl-1H-pyrazole-4-carboxylate(cas: 5952-93-2Related Products of 5952-93-2)
Methyl 1-methyl-1H-pyrazole-4-carboxylate(cas: 5952-93-2) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Related Products of 5952-93-2
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics