Sun, Xiaohua; Feng, Lijun; Sun, Chuance; Kang, Congmin published their research in Pharmaceutical Chemistry Journal on December 31 ,2021. The article was titled 《Synthesis of Quinoxaline Derivatives as Intermediates to Obtain Erdafitinib》.Related Products of 930-36-9 The article contains the following contents:
In this work, quinoxaline derivative 7-bromo-2-(1-methyl-1H-pyrazol-4-yl)quinoxaline, which is an essential intermediate to obtain drug erdafitinib, has been synthesized in reasonably good yield using 4-bromobenzene-1,2-diamine and 2-bromo-1-(1-methyl-1H-pyrazol-4-yl)ethan-1-one as raw materials, triethylene diamine (DABCO) as catalyst, and THF as solvent. To the best of authors’ knowledge, this is the first time 7-bromo-2-(1-methyl-1H-pyrazol-4-yl)quinoxaline has been acquired by the proposed method. In the experiment, the researchers used 1-Methylpyrazole(cas: 930-36-9Related Products of 930-36-9)
1-Methylpyrazole(cas: 930-36-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Related Products of 930-36-9
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics