pyrazoles-derivatives

Electric Literature of 99662-34-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 99662-34-7 name is 4-Pyrazol-1-yl-benzaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a cooled solution of 4-(pyrazol-l-yl)benzaldehyde (3.0 g, 0.017 mole) in methanol (20 mL) under N2, was added sodium borohydride (0.79 g, 0.02 mole) in portion wise. The reaction mixture was warmed to RT and stirred for 2 h. The reaction mixture was concentrated under vacuum, dissolved in ice cold water (75 mL) and extracted with ethyl acetate (100 mL x 2). Organic layer was washed with brine solution (50 mL), dried over Na2S04 and concentrated under vacuum to obtain the crude compound which was further purified by flash chromatography using ethyl acetate: n-hexane (40:60) to get l-(4- hydroxymethylphenyl) – 1 H-pyrazole . (0225) Yield: 2.4 g; 1H – NMR (DMSO- 6, 400 MHz) d ppm: 4.52 – 4.53 (d, J = 5.6 Hz, 2H), 5.23 – 5.26 (t, J = 5.7 Hz, 1H), 6.52 (s, 1H), 7.41 – 7.43 (d, J = 8.3 Hz, 2H), 7.72 (s, 1H), 7.77 – 7.79 (d, J = 8.3 Hz, 2H), 8.09 (d, J = 2.3 Hz, 1H); Mass (m/z): 175.1 (M+H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Pyrazol-1-yl-benzaldehyde, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3463-30-7, name is 1-(4-Nitrophenyl)-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 3463-30-7

To the reaction flask was added successively 1-(4-nitrophenyl)-1H-pyrazole (40.00 g, 211.45 mmol), ethanol (400 ml), 85% hydrazine hydrate (37.36 g, 634.34 mmol) and 10% palladium on carbon catalyst (3.38 g, 3.17 mmol) and the reaction was heated to reflux. After the reaction was refluxed for 0.5 hours, the reaction solution was cooled to room temperature, filtered to remove the palladium on carbon catalyst, concentrated under reduced pressure, to the residue was added water (300 ml), and extracted with ethyl acetate (3 ¡Á 500 ml), the organic layer was washed with saturated under brine (200 ml), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure, and the residue was purified by column chromatography (as eluent PE: EA = 1: 1 (v / v)), light yellow solid 26.92 g, yield 79.98%.

According to the analysis of related databases, 3463-30-7, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 52867-42-2, name is Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52867-42-2, Computed Properties of C6H8N2O3

To a stirred suspension of methyl 5-hydroxy-2-methyl-pyrazole-3-carboxylate (3.00 g, 19.0 mmol) and K2CO3 (2.90 g, 21.0 mmol) in DMF (19 mL) at room temperature was added iodoethane (1.71 mL, 21.0 mmol) and the reaction mixture stirred at 50 C for 16 h. The reaction mixture was diluted with water (190 mL) and the aqueous layer extracted with ethyl acetate (3 x 100 mL). The combined organic layers were washed with water (2 x 100 mL), passed through a phase separator and concentrated in vacuo. The crude material was purified by flash chromatography [EtOAc/isohexanes (0-50%)] to afford the title compound (3.33 g, 94% Yield) as a colourless oil. 6H (300 MHz, d-Chloroform) 6.17 (s, 1H), 4.16 (q, J = 7.1 Hz, 2H), 4.03 (s, 3H), 3.86 (s, 3H), 1.38 (t, J = 7.1 Hz, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Electric Literature of 120068-79-3,Some common heterocyclic compound, 120068-79-3, name is 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile, molecular formula is C11H5Cl2F3N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of compound A (5 mmol) and corresponding benzaldehyde (5 mmol) in 10 mL ethanol was refluxed for 24 hours in a reaction flask wrapped up by silver paper. Upon the reactions completed (monitored by TLC), tawny solids were obtained through suction filtration. The precipitates were washed with ethanol (5 mLx3) and recrystallized from ethanol with 50-84% yields.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1146629-77-7, name is (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 1146629-77-7

4-(1-(2-Cyano-1-cyclopentylvinyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate (9).; To a 500 mL round bottom flask equipped with a stir bar and the nitrogen inlet was charged 3-cyclopentylpropiolonitrile (8, 8.50 g, 0.0713 mol, 1.52 equiv), N,N-dimethylformamide (DMF, 84 mL, 1.08 mol) and [4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl pivalate (5, 14.0 g, 0.0468 mol) and solid potassium carbonate (K2CO3, 0.329 g, 0.00238 mol, 0.05 equiv) at room temperature. The resulting reaction mixture was then stirred at room temperature for 60 min. When TLC and HPLC showed that the reaction was deemed complete, the reaction mixture was quenched with 20% aqueous brine (75 mL) and the resulting solution was extracted with ethyl acetate (EtOAc, 3¡Á75 mL). The combined organic extracts were washed with 20% aqueous brine (75 mL), dried over magnesium sulfate (MgSO4), filtered, and concentrated under reduced pressure. The residue was purified by flash chromatography (SiO2, 0 to 20% ethyl acetate/hexane gradient elution) to afford 4-(1-(2-cyano-1-cyclopentylvinyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate (9, 16.4 g, 19.6 g theoretical, 83.7% yield) as white solids. For 9: 1H NMR (DMSO-d6, 300 MHz) delta 9.09 (s, 1H), 8.84 (s, 1H), 8.63 (s, 1H), 7.78 (d, 1H, J=3.8 Hz), 7.17 (d, 1H, J=3.8 Hz), 6.24 (s, 2H), 5.82 (s, 1H), 3.55 (m, 1H), 1.92 (m, 2H), 1.59 (br m, 6H), 1.06 (s, 9H); C23H26N6O2 (MW, 418.49), LCMS (EI) m/e 419 (M++H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1146629-77-7.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1260243-04-6, name is Ethyl 5-amino-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., category: pyrazoles-derivatives

EXAMPLE 53 4,5,6,7-Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid, ethyl ester A stirred mixture of 10.88 g of 5-amino-4-pyrazolecarboxylic acid, ethyl ester, 11.51 g of malonaldehyde bis(dimethyl acetal) and 100 ml of glacial acetic acid was heated at reflux for 16 hours, then worked up as described in Example 50 to give 7.8 g of pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, ethyl ester.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 67-51-6,Some common heterocyclic compound, 67-51-6, name is 3,5-Dimethyl-1H-pyrazole, molecular formula is C5H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1 1-(4-Methoxy-phenyl)-3,5-dimethyl-1-H-pyrazole: The title compound was prepared from 4-methoxyphenylboronic acid (1.58 g, 10.4 mmol), 3,5-dimethyl-1H-pyrazoles (0.5 g, 5.2 mmol) using the general procedure A with a yield of 90% (0.9 g,); MS (APCI) m/z: 203 (M+1, 100).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Dimethyl-1H-pyrazole, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 30169-25-6, name is 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 30169-25-6, Formula: C12H14N8

1,2,4,5-tetrazine-3,6-diamine (56 mg, 0.5 mmol) was added to 3,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine (270 mg, 1 mmol) and K2CO3 (138 mg, 1 mmol) with 10 mL acetonitrile, and refluxed (80C) for 20 hours. Reaction was monitored with TLC using a 3:1 CCl4:CH3CN solvent system. The resulting dark, viscous solution was cooled with 10 mL ice water followed by 5% HCl added dropwise until the pH was about 1. The red precipitate was filtered and washed with water to yield 250 mg (109% yield, due to water in the sample).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 4149-06-8, name is 3-Amino-1-phenyl-1H-pyrazol-5(4H)-one, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4149-06-8, Recommanded Product: 4149-06-8

A solution of 3-amino-1-phenyl-2-pyrazolin-5-one 1 (0.35 g, 2 mmol), dimedone 2 (0.28 g, 2 mmol), aldehyde 3 (0.28 mg, 2 mmol) and Cell-LA-TEA+/Fe3O4 nanocatalyst (0.03 g, 0.09 mol%) in H2O/EtOH (3:2) was subjected to ultrasonic irradiation (ultrasonic bath, room temperature). The progress of the reaction was controlled by TLC (hexane/ethyl acetate, 2:3). After reaction completion, the nanocatalyst was separated magnetically from the reaction mixture and used for subsequent cycles after washing with ethanol. By cooling the reaction solution, the solid product was collected, separated and recrystallized from methanol to get the pure product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Amino-1-phenyl-1H-pyrazol-5(4H)-one, other downstream synthetic routes, hurry up and to see.

Reference of 866837-96-9,Some common heterocyclic compound, 866837-96-9, name is Ethyl 5-amino-1-phenyl-1H-pyrazole-3-carboxylate, molecular formula is C12H13N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5-Amino-1-phenyl-lH-pyrazole-3-carboxylic acid ethyl ester (0.63 g, 2.72 mmoles) was dissolved in 10 ml of anhydrous tetrahydrofuran. Then, 442 mg of benzoyl thioisocyante (2.72 mmoles) was added. The mixture was heated at 90C for 2 hours and the reaction was monitored by LCMS. After the completion of reaction, the THF was removed in vacuo to give 1.02 g of desired product (yield: 96%), which was dried under high vacuum. The product was used for the next step without further purification

The synthetic route of 866837-96-9 has been constantly updated, and we look forward to future research findings.